Perioperative hepatocyte growth factor (HGF) infusions improve hepatic regeneration following portal branch ligation (PBL) in rodents

2016 ◽  
Vol 31 (7) ◽  
pp. 2789-2797 ◽  
Author(s):  
Christopher W. Mangieri ◽  
Jason C. McCartt ◽  
Matthew A. Strode ◽  
John E. Lowry ◽  
Prasad M. Balakrishna
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Hepatic Regeneration ◽  
Portal Branch ◽  
Portal Branch Ligation ◽  
Hepatocyte Growth

scholarly journals Portal branch ligation with a continuous hepatocyte growth factor supply makes extensive hepatectomy possible in cirrhotic rats

Hepatology ◽  
1998 ◽  
Vol 28 (3) ◽  
pp. 756-760 ◽  
Author(s):  
Toshimi Kaido ◽  
Akira Yoshikawa ◽  
Shin-ichi Seto ◽  
Shoji Yamaoka ◽  
Maki Sato ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Portal Branch ◽  
Extensive Hepatectomy ◽  
Portal Branch Ligation ◽  
Hepatocyte Growth

Hepatocyte Growth Factor Supply Accelerates Compensatory Hypertrophy Caused by Portal Branch Ligation in Normal and Jaundiced Rats

1999 ◽  
Vol 85 (1) ◽  
pp. 115-119 ◽  
Author(s):  
Toshimi Kaido ◽  
Akira Yoshikawa ◽  
Shin-ichi Seto ◽  
Shoji Yamaoka ◽  
Maki Sato ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Compensatory Hypertrophy ◽  
Portal Branch ◽  
Portal Branch Ligation ◽  
Hepatocyte Growth

Exogenous hepatocyte growth factor markedly stimulates liver regeneration following portal branch ligation in dogs

1996 ◽  
Vol 38 (3) ◽  
pp. 233-237 ◽  
Author(s):  
Shinichi Ueno ◽  
Takashi Aikou ◽  
G. Tanabe ◽  
Yasuyuki Kobayashi ◽  
Masahiro Hamanoue ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Liver Regeneration ◽  
Portal Branch ◽  
Portal Branch Ligation ◽  
Hepatocyte Growth

scholarly journals Hepatocyte growth factor and transforming growth factor β regulate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression in rat hepatocyte primary cultures

1996 ◽  
Vol 314 (1) ◽  
pp. 235-240 ◽  
Author(s):  
Manel JOAQUIN ◽  
Jose Luis ROSA ◽  
Cristina SALVADÓ ◽  
Sofía LÓPEZ ◽  
Toshikazu NAKAMURA ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Kinase Activity ◽  
Transforming Growth Factor ◽  
Primary Cultures ◽  
Transforming Growth Factor Β ◽  
Hepatic Regeneration ◽  
Rat Hepatocyte ◽  
Hepatocyte Growth

Hepatocyte growth factor (HGF) and transforming growth factor β (TGF-β) are believed to be of major importance for hepatic regeneration after liver damage. We have studied the effect of these growth factors on fructose 2,6-bisphosphate (Fru-2,6-P2) levels and the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (6PF2K/Fru-2,6-BPase) in rat hepatocyte primary cultures. Our results demonstrate that HGF activates the expression of the 6PF2K/Fru-2,6-BPase gene by increasing the levels of its mRNA. As a consequence of this activation, the amount of 6PF2K/Fru-2,6-BPase protein and 6-phosphofructo-2-kinase activity increased, which was reflected by a rise in Fru-2,6-P2 levels. In contrast, TGF-β decreased the levels of 6PF2K/Fru-2,6-BPase mRNA, which led to a decrease in the amount of 6PF2K/Fru-2,6-BPase protein and Fru-2,6-P2. The different actions of HGF and TGF-β on 6PF2K/Fru-2,6-BPase gene expression are concomitant with their effect on cell proliferation. Here we show that, in the absence of hormones, primary cultures of hepatocytes express the F-type isoenzyme. In addition, HGF increases the expression of this isoenzyme, and dexamethasone activates the L-type isoform. HGF and TGF-β were able to inhibit this activation.

scholarly journals Beneficial Effect of Deletion Variant of Hepatocyte Growth Factor for Impaired Hepatic Regeneration in the Ischemically Damaged Liver

2002 ◽  
Vol 26 (10) ◽  
pp. 1260-1266 ◽  
Author(s):  
Kazuya Okamoto ◽  
Shohachi Suzuki ◽  
Kiyotaka Kurachi ◽  
Kenichi Sunayama ◽  
Yoshihiro Yokoi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Beneficial Effect ◽  
Hepatic Regeneration ◽  
Deletion Variant ◽  
Hepatocyte Growth

Role of Bcl-xL in hepatocyte growth factor-elicited epithelial protection in idiopathic pulmonary fibrosis

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
S Skwarna ◽  
I Henneke ◽  
W Seeger ◽  
T Geiser ◽  
A Günther ◽  
...  
Keyword(s):  
Growth Factor ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Hepatocyte Growth Factor ◽  
Hepatocyte Growth
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