Effect of ulinastatin on postoperative renal function in patients undergoing robot-assisted laparoscopic partial nephrectomy: a randomized trial

2017 ◽  
Vol 31 (9) ◽  
pp. 3728-3736 ◽  
Author(s):  
Bora Lee ◽  
Sook Young Lee ◽  
Na Young Kim ◽  
Koon Ho Rha ◽  
Young Deuk Choi ◽  
...  
2014 ◽  
Vol 8 (11-12) ◽  
pp. 810 ◽  
Author(s):  
Jeong Woo Lee ◽  
Sung Yong Cho ◽  
Chanhoo Jeon ◽  
Kyungtae Ko ◽  
Hyeon Hoe Kim

Introduction: We evaluated the the association between PADUA scores and postoperative renal function (after robot-assisted partial nephrectomy [RAPN]) and between PADUA scores and warm ischemic time (during RAPN).Methods: We reviewed the clinical records of 106 patients who underwent RAPN for a single localized renal tumour between April 2009 and June 2012. Postoperative renal function was evaluated using estimated glomerular filtration rate (eGFR) in 85 patients who were followed for at least 6 months. PADUA scores for renal tumours were calculated using contrast-enhanced computed tomography images, if needed, along with magnetic resonance images in some cases.Results: A PADUA score ≥10 and WIT ≥30 minutes were observed in 18 (17.0%) and 51 (48.1%) cases, respectively. PADUA scores were significantly correlated with WIT (p = 0.019) and percent change in eGFR at 6 months postoperatively (p = 0.005). PADUA score (continuous variable, odds ratio [OR] 1.694, p = 0.007) and the high-risk group (PADUA score ≥10) (OR 5.429; p = 0.020) were significantly associated with a WIT of ≥30 minutes by multivariate analysis. A 1-point increase in the PADUA score was associated with an eGFR decrease of >20% at 6 months after RAPN (OR 1.799; p = 0.076). In addition, a PADUA score ≥10, or high risk, (OR 13.965; p = 0.003) was an independent predictor of an eGFR decrease of >20% at 6 months after RAPN.Conclusions: The PADUA classification can reliably predict WIT and postoperative renal functional outcome after RAPN. Furthermore, the study suggests that anatomical aspects of renal tumours are associated with functional outcome after RAPN.


Cureus ◽  
2021 ◽  
Author(s):  
Deepak Raghavan ◽  
Mathisekaran Thangarasu ◽  
Sanjay Prakash J ◽  
Rajesh Paul ◽  
Nivash Selvaraj

2014 ◽  
Vol 20 (3) ◽  
pp. 586-592 ◽  
Author(s):  
Hideaki Miyake ◽  
Junya Furukawa ◽  
Nobuyuki Hinata ◽  
Mototsugu Muramaki ◽  
Kazushi Tanaka ◽  
...  

2009 ◽  
Vol 181 (4S) ◽  
pp. 247-248
Author(s):  
Sebastien Crouzet ◽  
Georges-Pascal Haber ◽  
Kamoi Kazumi ◽  
Andre Berger ◽  
Raj K Goel ◽  
...  

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 759
Author(s):  
Hui-Ying Liu ◽  
Chih Hsiung Kang ◽  
Hung-Jen Wang ◽  
Chien Hsu Chen ◽  
Hao Lun Luo ◽  
...  

Preserving renal function and controlling oncological outcomes are pertinent when managing renal neoplasms. Cryoablation is the recommended treatment only for clinical T1a stage renal tumour. Here, we compared the outcomes of robot-assisted laparoscopic partial nephrectomy (RaPN) and laparoscopic cryoablation (LCA) in the treatment of patients with localised T1-T2 renal tumours. Overall, 86 patients who received RaPN and 78 patients underwent LCA were included in this study. The intraoperative, postoperative, and oncological outcomes in the LCA group were non-inferior to the RaPN group. Moreover, LCA demonstrated shorter operative time (267.45 ± 104.53 min vs. 138.56 ± 45.28 min, p < 0.001), lower blood loss (300.56 ± 360.73 mL vs. 30.73 ± 50.31 mL, p < 0.001), and slight renal function deterioration because of the reduced invasiveness, without compromising on the oncological outcomes.


F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 108 ◽  
Author(s):  
Kevin Lah ◽  
Devang Desai ◽  
Charles Chabert ◽  
Christian Gericke ◽  
Troy Gianduzzo

Introduction: The aim of this study was to assess the outcomes of early vascular release in robot-assisted laparoscopic partial nephrectomy (RAPN) to reduce warm ischaemia time (WIT) and minimise renal dysfunction. RAPN is increasingly utilised in the management of small renal masses. To this end it is imperative that WIT is kept to a minimum to maintain renal function.Methods: RAPN was performed via a four-arm robotic transperitoneal approach. The renal artery and vein were individually clamped with robotic vascular bulldog clamps to allow cold scissor excision of the tumour. The cut surface was then sutured with one or two running 3-0 V-LocTM sutures, following which the vascular clamps were released. Specific bleeding vessels were then selectively oversewn and the collecting system repaired. Renorrhaphy was then completed using a running horizontal mattress 0-0 V-LocTM suture.Results: A total of 16 patients underwent RAPN with a median WIT of 15 minutes (range: 8-25), operative time 230 minutes (range: 180-280) and blood loss of 100 mL (range: 50-1000). There were no transfusions, secondary haemorrhages or urine leaks. There was one focal positive margin in a central 5.5 cm pT3a renal cell carcinomas (RCC). Long-term estimated glomerular filtration rate (eGFR) was not significantly different to pre-operative values.Conclusion: In this patient series, early vascular release effectively minimised WIT and maintained renal function without compromising perioperative safety.


2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yunqiang Xiong ◽  
Wen Deng ◽  
Ru Chen ◽  
Xiaoqiang Liu ◽  
Ke Zhu ◽  
...  

Background. To compare the perioperative and functional outcomes between robot-assisted partial nephrectomy (RAPN) and laparoscopic partial nephrectomy (LPN) for giant sporadic renal angiomyolipomas (AMLs) of ≥7 cm. Materials and Methods. Patients with sporadic renal AMLs of ≥7 cm who underwent RAPN or LPN in the First Affiliated Hospital of Nanchang University between 2015 and 2020 were retrospectively analyzed. Propensity score matching (1 : 1) was performed to adjust for potential baseline confounders. Perioperative and functional outcomes of the RAPN and LPN groups were collected and compared. Result. After propensity score matching, no statistically significant differences in baseline characteristics were found between the groups (41 vs. 41). Within the matched cohort, the warm ischemia time (WIT) in the RAPN group was significantly shorter than that in the LPN group (21 vs. 27 min, p < 0.001 ). In addition, the RAPN group was associated with improved postoperative renal function (72.8 vs. 69.8 mL/min/1.73 m2, p = 0.045 ). WIT and preoperative renal function are independent predictors of renal function at 6 months postoperatively, and renal score and operation method are independent predictors of WIT. Conclusion. RAPN and LPN are safe and feasible minimally invasive treatments for sporadic giant renal AMLs, but RAPN is associated with shorter WIT and better postoperative renal functional preservation. WIT and preoperative renal function are independent predictors of renal function at 6 months postoperatively, while the RENAL score and surgical method are independent risk factors to WIT. For giant and complex renal AMLs, RAPN is the first choice when condition permits.


2007 ◽  
Vol 40 (2) ◽  
pp. 277-282 ◽  
Author(s):  
Takahiro Yasui ◽  
Yasunori Itoh ◽  
Yoshiyuki Kojima ◽  
Yukihiro Umemoto ◽  
Keiichi Tozawa ◽  
...  

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