Routine near infra-red indocyanine green fluorescent cholangiography versus intraoperative cholangiography during laparoscopic cholecystectomy: a case-matched comparison

2019 ◽  
Vol 34 (5) ◽  
pp. 1959-1967 ◽  
Author(s):  
Silvia Quaresima ◽  
Andrea Balla ◽  
Livia Palmieri ◽  
Ardit Seitaj ◽  
Abe Fingerhut ◽  
...  
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Indocyanine Green ◽  
Intraoperative Cholangiography ◽  
Fluorescent Cholangiography ◽  
Infra Red ◽  
Green Fluorescent ◽  
Matched Comparison

scholarly journals P11: NEAR INFRARED FLUORESCENT CHOLANGIOGRAPHY IN LAPAROSCOPIC CHOLECYSTECTOMY: A SINGLE CENTRE FEASIBILITY STUDY. THE OPTIMUM DOSING REGIME, LIMITATIONS AND WHERE NEXT?

2021 ◽  
Vol 108 (Supplement_1) ◽  
Author(s):  
G Armstrong ◽  
G Toogood ◽  
DG Jayne ◽  
AM Smith
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Bile Duct ◽  
Indocyanine Green ◽  
Feasibility Study ◽  
Near Infrared ◽  
Intravenous Dose ◽  
Structure Identification ◽  
Dosing Regimen ◽  
Single Centre ◽  
Fluorescent Cholangiography

Abstract Introduction This study explored near-infrared fluorescent cholangiography (NIRFC) with Indocyanine Green (ICG) during laparoscopic cholecystectomy (LC) surgery in a tertiary referral hepatobiliary unit. ICG binds to albumin and is excreted in bile. NIRFC utilises the fluorescent and excretory properties of ICG to provide dynamic extrahepatic bile duct mapping during LC. Method Non-randomised single centre feasibility study. Twenty-two participants were sequentially allocated to four dosing subgroups prior to NIRFC assisted LC. Each received a single intravenous dose of ICG prior to LC with the Stryker Novadaq NIR laparoscope. The biliary anatomy was assessed with NIRFC at three time-points, detection was compared to radiological cholangiogram where available and surgeon satisfaction was assessed. Result Eight participants received 2.5mg ICG 20-40min before surgery, four 0.25mg/kg 20-40min, five 90min – 180min and five 12 – 36 hour pre-operatively. Average age 50 years (S.D±15), BMI 27.5m2 (S.D±3.6), 6/22 were acute LC procedures. The prolonged dosing interval produced increased extrahepatic biliary structure identification (p = 0.016), reduced noise to signal ratio and was consistently preferred by the operating surgeon. NIRFC was inferior to radiological cholangiogram (n = 10) (p = 0.014) for bile duct mapping. We observed iatrogenic bile spillage saturating the field and obscuring structure differentiation and peri-hilar inflammation impeding fluorescent detection in acute LC. Conclusion The dosing regimen 0.25mg/kg ICG 12 to 36 hours prior to surgery provides optimum NIRFC structure visualisation. Fluorescent tissue penetrance is limited in acute peri-hilar inflammation. More research in to the efficiency of NIRFC in emergency LC is required. Take-home message An intravenous dose of 0.25mg/kg of Indocyanine Green 12 to 36 hours before surgery is the optimum dosing regimen for increased extra-hepatic bile duct structures with near infrared fluorescent cholangiography. The role of NIRFC in acute laparoscopic cholecystectomy surgery remains ill-defined.

scholarly journals Systematic Review Protocol. Near Infra-Red Indocyanine Green Fluorescent Cholangiography Versus Intraoperative Cholangiography to Improve Safety in Laparoscopic Cholecystectomy for Gallstone Disease – A Systematic Review Protocol.

2020 ◽  
Author(s):  
Mar Achalandabaso Boira ◽  
Robert Memba ◽  
Yasir Bashir ◽  
Mihai Calin Pavel ◽  
Erik Llacer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gallstone Disease ◽  
Controlled Trials ◽  
Systematic Review Protocol ◽  
Biliary Anatomy ◽  
Fluorescent Cholangiography ◽  
Infra Red ◽  
Review Protocol ◽  
Green Fluorescent ◽  
Randomised Controlled

Abstract BackgroundLaparoscopic cholecystectomy has become the standard surgical approach in the treatment of cholelithiasis. The rate of bile duct injury increased significantly during the initial period of its implementation. Diverse surgical techniques and different imaging modalities have been described to provide enhanced views of the biliary anatomy and potentially prevent or early detect bile duct injuries. Both x-ray intraoperative cholangiography (IOC) and Near infra-red indocyanine green fluorescent cholangiography (NIR-ICG) have been described as safe and feasible techniques to assess biliary anatomy. The aim of this systematic review is to evaluate if NIR-ICG can visualise extrahepatic biliary anatomy more efficiently and safer than IOC in minimally invasive cholecystectomy for gallstone disease.MethodsLiterature search will be performed via Medline (PubMed), Embase, Scopus, the Cochrane Central Register of Controlled Trials and web of science. All randomised controlled clinical trials and prospective non-randomised controlled trials which report on comparison of NIR-ICG versus IOC will be included. All patients over 18 years old who require elective or urgent minimally invasive cholecystectomy (undergoing NIR-ICG during this procedure) due to gallstone disease both acute and chronic will be included. Primary outcomes will be ability to visualise extrahepatic biliary anatomy and time to obtain relevant images of the biliary tree.DiscussionOur research expects to give the reader a clear sense of the needed focus of future research and remaining uncertainties in the field. Understanding the benefits of this technique is critical to ensuring policymakers can make informed decisions as to where preventive efforts should be focused regarding specific imaging techniques. If ICG is proven to be faster and non-invasive, routine use could be encouraged and wide implementation could be a reality. Systematic review registrationIn accordance with the guidelines, our systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO), registration number CRD42020177991.

Fluorescent Cholangiography during Laparoscopic Cholecystectomy: Indocyanine Green or New Fluorescent Agents? Letter to the Editor

2010 ◽  
Vol 34 (10) ◽  
pp. 2505-2506 ◽  
Author(s):  
Takeaki Ishizawa ◽  
Yasutsugu Bandai ◽  
Kiyoshi Hasegawa ◽  
Norihiro Kokudo
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Indocyanine Green ◽  
Fluorescent Cholangiography ◽  
Letter To The Editor

scholarly journals Indocyanine green (ICG) fluorescent cholangiography during laparoscopic cholecystectomy using RUBINA™ technology: preliminary experience in two pediatric surgery centers

2021 ◽  
Author(s):  
Ciro Esposito ◽  
Daniele Alberti ◽  
Alessandro Settimi ◽  
Silvia Pecorelli ◽  
Giovanni Boroni ◽  
...  
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Indocyanine Green ◽  
Pediatric Surgery ◽  
Pediatric Patients ◽  
New Technology ◽  
Technical Failure ◽  
Biliary Anatomy ◽  
Fluorescent Cholangiography ◽  
Surgery Patient ◽  
Nirf Imaging

Abstract Background Recently, we reported the feasibility of indocyanine green (ICG) near-infrared fluorescence (NIRF) imaging to identify extrahepatic biliary anatomy during laparoscopic cholecystectomy (LC) in pediatric patients. This paper aimed to describe the use of a new technology, RUBINA™, to perform intra-operative ICG fluorescent cholangiography (FC) in pediatric LC. Methods During the last year, ICG-FC was performed during LC using the new technology RUBINA™ in two pediatric surgery units. The ICG dosage was 0.35 mg/Kg and the median timing of administration was 15.6 h prior to surgery. Patient baseline, intra-operative details, rate of biliary anatomy identification, utilization ease, and surgical outcomes were assessed. Results Thirteen patients (11 girls), with median age at surgery of 12.9 years, underwent LC using the new RUBINA™ technology. Six patients (46.1%) had associated comorbidities and five (38.5%) were practicing drug therapy. Pre-operative workup included ultrasound (n = 13) and cholangio-MRI (n = 5), excluding biliary and/or vascular anatomical anomalies. One patient needed conversion to open surgery and was excluded from the study. The median operative time was 96.9 min (range 55–180). Technical failure of intra-operative ICG-NIRF visualization occurred in 2/12 patients (16.7%). In the other cases, ICG-NIRF allowed to identify biliary/vascular anatomic anomalies in 4/12 (33.3%), including Moynihan's hump of the right hepatic artery (n = 1), supravescicular bile duct (n = 1), and short cystic duct (n = 2). No allergic or adverse reactions to ICG, post-operative complications, or reoperations were reported. Conclusion Our preliminary experience suggested that the new RUBINA™ technology was very effective to perform ICG-FC during LC in pediatric patients. The advantages of this technology include the possibility to overlay the ICG-NIRF data onto the standard white light image and provide surgeons a constant fluorescence imaging of the target anatomy to assess position of critical biliary structures or presence of anatomical anomalies and safely perform the operation.

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