Fibroblast growth factor 23 and left ventricular hypertrophy in children on dialysis

2012 ◽  
Vol 27 (11) ◽  
pp. 2129-2136 ◽  
Author(s):  
Wacharee Seeherunvong ◽  
Carolyn L. Abitbol ◽  
Jayanthi Chandar ◽  
Paolo Rusconi ◽  
Gaston E. Zilleruelo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Left Ventricular Hypertrophy ◽  
Fibroblast Growth Factor ◽  
Ventricular Hypertrophy ◽  
Fibroblast Growth Factor 23 ◽  
Left Ventricular ◽  
Fibroblast Growth

scholarly journals FP617CORRELATION BETWEEN HYPERVOLEMIA, LEFT VENTRICULAR HYPERTROPHY AND FIBROBLAST GROWTH FACTOR 23 IN HEMODIALYSIS PATIENTS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii278-iii279
Author(s):  
Suat Unver ◽  
Ela Kavlak ◽  
Hilal Kurtoglu Gümüsel ◽  
Fatma Celikbilek ◽  
Kenan Esertas ◽  
...  
Keyword(s):  
Growth Factor ◽  
Left Ventricular Hypertrophy ◽  
Fibroblast Growth Factor ◽  
Ventricular Hypertrophy ◽  
Fibroblast Growth Factor 23 ◽  
Hemodialysis Patients ◽  
Left Ventricular ◽  
Fibroblast Growth

Correlation between hypervolemia, left ventricular hypertrophy and fibroblast growth factor 23 in hemodialysis patients

Renal Failure ◽  
2015 ◽  
Vol 37 (6) ◽  
pp. 951-956 ◽  
Author(s):  
Suat Unver ◽  
Ela Kavlak ◽  
Hilal Kurtoglu Gümüsel ◽  
Fatma Celikbilek ◽  
Kenan Esertas ◽  
...  
Keyword(s):  
Growth Factor ◽  
Left Ventricular Hypertrophy ◽  
Fibroblast Growth Factor ◽  
Ventricular Hypertrophy ◽  
Fibroblast Growth Factor 23 ◽  
Hemodialysis Patients ◽  
Left Ventricular ◽  
Fibroblast Growth

scholarly journals Fibroblast Growth Factor 23, High-Sensitivity Cardiac Troponin, and Left Ventricular Hypertrophy in CKD

2013 ◽  
Vol 61 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Kelsey Smith ◽  
Christopher deFilippi ◽  
Tamara Isakova ◽  
Orlando M. Gutiérrez ◽  
Karen Laliberte ◽  
...  
Keyword(s):  
Growth Factor ◽  
Left Ventricular Hypertrophy ◽  
Fibroblast Growth Factor ◽  
Cardiac Troponin ◽  
Ventricular Hypertrophy ◽  
Fibroblast Growth Factor 23 ◽  
High Sensitivity ◽  
Left Ventricular ◽  
Fibroblast Growth

scholarly journals Cardiac Fibroblast Growth Factor 23 Excess Does Not Induce Left Ventricular Hypertrophy in Healthy Mice

2021 ◽  
Vol 9 ◽  
Author(s):  
Maren Leifheit-Nestler ◽  
Miriam A. Wagner ◽  
Beatrice Richter ◽  
Corinna Piepert ◽  
Fiona Eitner ◽  
...  
Keyword(s):  
Growth Factor ◽  
Left Ventricular Hypertrophy ◽  
Fibroblast Growth Factor ◽  
Ventricular Hypertrophy ◽  
Fibroblast Growth Factor 23 ◽  
Left Ventricular ◽  
Neonatal Rat ◽  
Fibroblast Growth ◽  
Hypertrophic Growth ◽  
Per Se

Fibroblast growth factor (FGF) 23 is elevated in chronic kidney disease (CKD) to maintain phosphate homeostasis. FGF23 is associated with left ventricular hypertrophy (LVH) in CKD and induces LVH via klotho-independent FGFR4-mediated activation of calcineurin/nuclear factor of activated T cells (NFAT) signaling in animal models, displaying systemic alterations possibly contributing to heart injury. Whether elevated FGF23 per se causes LVH in healthy animals is unknown. By generating a mouse model with high intra-cardiac Fgf23 synthesis using an adeno-associated virus (AAV) expressing murine Fgf23 (AAV-Fgf23) under the control of the cardiac troponin T promoter, we investigated how cardiac Fgf23 affects cardiac remodeling and function in C57BL/6 wild-type mice. We report that AAV-Fgf23 mice showed increased cardiac-specific Fgf23 mRNA expression and synthesis of full-length intact Fgf23 (iFgf23) protein. Circulating total and iFgf23 levels were significantly elevated in AAV-Fgf23 mice compared to controls with no difference in bone Fgf23 expression, suggesting a cardiac origin. Serum of AAV-Fgf23 mice stimulated hypertrophic growth of neonatal rat ventricular myocytes (NRVM) and induced pro-hypertrophic NFAT target genes in klotho-free culture conditions in vitro. Further analysis revealed that renal Fgfr1/klotho/extracellular signal-regulated kinases 1/2 signaling was activated in AAV-Fgf23 mice, resulting in downregulation of sodium-phosphate cotransporter NaPi2a and NaPi2c and suppression of Cyp27b1, further supporting the bioactivity of cardiac-derived iFgf23. Of interest, no LVH, LV fibrosis, or impaired cardiac function was observed in klotho sufficient AAV-Fgf23 mice. Verified in NRVM, we show that co-stimulation with soluble klotho prevented Fgf23-induced cellular hypertrophy, supporting the hypothesis that high cardiac Fgf23 does not act cardiotoxic in the presence of its physiological cofactor klotho. In conclusion, chronic exposure to elevated cardiac iFgf23 does not induce LVH in healthy mice, suggesting that Fgf23 excess per se does not tackle the heart.

Fibroblast growth factor 23 is associated with left ventricular hypertrophy, not with uremic vasculopathy in peritoneal dialysis patients

2016 ◽  
Vol 85 (2016) (03) ◽  
pp. 135-141 ◽  
Author(s):  
Margarida Sarmento-Dias ◽  
Carla Santos-Araújo ◽  
Rui Poínhos ◽  
Bruno Oliveira ◽  
Isabell Soares Silva ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Growth Factor ◽  
Left Ventricular Hypertrophy ◽  
Fibroblast Growth Factor ◽  
Ventricular Hypertrophy ◽  
Fibroblast Growth Factor 23 ◽  
Left Ventricular ◽  
Fibroblast Growth ◽  
Dialysis Patients
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