Benign and malignant proliferation in idiopathic nephrotic syndrome: a French cohort study

2022 ◽  
Author(s):  
Clara Cébron ◽  
Astrid Godron-Dubrasquet ◽  
Nathalie Aladjidi ◽  
Gwenaelle Roussey ◽  
Olivia Boyer ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Cohort Study ◽  
Idiopathic Nephrotic Syndrome ◽  
French Cohort

Five-year outcome of children with idiopathic nephrotic syndrome: the NEPHROVIR population-based cohort study

2018 ◽  
Vol 34 (4) ◽  
pp. 671-678 ◽  
Author(s):  
Claire Dossier ◽  
Jean-Daniel Delbet ◽  
Olivia Boyer ◽  
Patrick Daoud ◽  
Bettina Mesples ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Cohort Study ◽  
Idiopathic Nephrotic Syndrome ◽  
Population Based

scholarly journals Relationships between the clinical phenotypes and genetic variants associated with the immunological mechanism in childhood idiopathic nephrotic syndrome: protocol for a prospective observational single-centre cohort study

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e028717
Author(s):  
Han Chan ◽  
Hao Lee ◽  
Xia Yang ◽  
Jingzhi Wang ◽  
Xueying Yang ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Cohort Study ◽  
Exome Sequencing ◽  
Genetic Variants ◽  
Idiopathic Nephrotic Syndrome ◽  
Single Centre ◽  
Clinical Phenotypes ◽  
Whole Exome ◽  
Medical University ◽  
Frequent Relapse

IntroductionIdiopathic nephrotic syndrome (INS) is the most common glomerulopathy that results in childhood chronic kidney disease in China, but the relationships between different clinical phenotypes and immunological genetic variants observed in patients with INS are ambiguous and have not been well studied. A cohort study combined with whole exome sequencing might further identify the effects of immunological genetic variants on clinical phenotypes and treatment outcomes.Methods and analysisWe describe a 3 year prospective observational single-centre cohort study to be conducted in the Children’s Hospital of Chongqing Medical University in China. This study will recruit and investigate 336 patients with childhood-onset INS presenting with different clinical phenotypes. Whole exome sequencing will be conducted when patients progress to a confirmed clinical phenotype during follow-up. Relevant clinical and epidemiological data, as well as conventional specimens, will be collected at study entry and 1 month, 3 months, 6 months, 1 year, 2 years and 3 years after disease onset. After this cohort is generated, the immunological genetic variants of steroid-sensitive nephrotic syndrome without frequent relapse, steroid-resistant nephrotic syndrome and steroid-dependent/frequent relapse nephrotic syndrome will be evaluated.Ethics and disseminationThe study protocol is approved by Ethics Committee of Children’s Hospital of Chongqing Medical University (reference number 2018–140). The results will be disseminated through peer-reviewed journals and conference presentations.Trial registration numberChiCTR1800019795

Predictors of remission and relapse in idiopathic nephrotic syndrome: a prospective cohort study

2014 ◽  
Vol 29 (6) ◽  
pp. 1039-1046 ◽  
Author(s):  
Premala Sureshkumar ◽  
Elisabeth M. Hodson ◽  
Narelle S. Willis ◽  
Federica Barzi ◽  
Jonathan C. Craig
Keyword(s):  
Nephrotic Syndrome ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Idiopathic Nephrotic Syndrome

RNA expression as a prognostic tool in idiopathic nephrotic syndrome

2007 ◽  
Vol 148 (23) ◽  
pp. 1067-1075
Author(s):  
Krisztina Fischer ◽  
Orsolya Galamb ◽  
Béla Molnár ◽  
Zsolt Tulassay ◽  
András Szabó
Keyword(s):  
Nephrotic Syndrome ◽  
Northern Blot ◽  
Idiopathic Nephrotic Syndrome ◽  
Minimal Change ◽  
Ribonuclease Protection Assay ◽  
Rna Expression ◽  
Rt Pcr ◽  
Protection Assay ◽  
Ribonuclease Protection

A gyermekkori nephrosis 90%-a idiopathiás nephrosis szindróma. Az idetartozó három kórkép, a minimal change betegség, a mesangialis proliferatio és a focalis sclerosis hasonló klinikai képpel jelentkező, eltérő prognózisú és terápiás válaszú betegség. Dolgozatunk célja az idiopathiás nephrosis szindrómába tartozó kórképek kialakulásával, progressziójával összefüggő genetikai ismeretek, génexpressziós változások áttekintése és funkcionális csoportosítása. A génexpressziós változások meghatározásának eszközeként, dolgozatunk röviden összefoglalja a northern blot, a ribonuclease protection assay, az in situ RNS-hibridizáció, a kvantitatív RT-PCR és a microarray módszerek lényegét. Az eddig elvégzett vizsgálatok a DNS-szintézis és repair gének, növekedési faktorok, extracelluláris mátrix, extracelluláris ligandreceptorok, extracelluláris jelátvitel zavarai mellett kiemelik a metabolikus és transzporter gének, illetve az immunszabályozó gének molekuláris eltéréseit, amelyek összefüggésben vannak az idiopathiás nephrosis szindróma eddig megismert molekuláris hátterével. A chiptechnológia fejlődésével és elterjedésével ezek a markerek és a hagyományos vizsgálati módszerek párhuzamos alkalmazása rutindiagnosztikai szempontból is fontossá válhat.

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