Machine learning (ML) has evolved to the point that this technique enhances communications and enables fifth-generation (5G) wireless networks. ML is great to get insights about complex networks that use large amounts of data, and for predictive and proactive adaptation to dynamic wireless environments. ML has become a crucial technology for mobile broadband communication. Special case goes to deep learning (DL) in immersive media. Through this chapter, the goal is to present open research challenges and applications of ML. An exploration of the potential of ML-based solution approaches in the context of 5G primary eMBB, mMTC, and uHSLLC services is presented, evaluating at the same time open issues for future research, including standardization activities of algorithms and data formats.