A guided self-help intervention targeting psychological distress among head and neck cancer and lung cancer patients: motivation to start, experiences and perceived outcomes

The article showed the study of chromatid type aberrations and genome abnormalities in 65 cancer patients at the stages of radiotherapy depending on tumor localization. Оncogynecological patients (with cancer in female reproductive system), lung cancer patients and head and neck cancer patients were examined before treatment, in the middle and at the end of the radiotherapy course. The over-spontaneous level of chromatid type aberrations and genomic abnormalities in cancer patients before the radiotherapy start was noted. The highest level of chromatid type aberrations before treatment was observed in lung cancer patients. No significant changes in the level of chromatid aberrations in oncogynecological patients during the whole radiotherapy course were detected. In the middle of treatment there was a significant frequency increase of chromatid type aberrations in head and neck cancer patients compared with pre-radiotherapy values of these parameters. This increase disappeared at the end of the radiotherapy course. In contrast to oncogynecological cancer patients and head and neck cancer patients in the group of lung cancer patients there was a significant increase of chromatid type damage level from the beginning to the end of the radiotherapy. The accumulation of radiation-non-specific rearrangements was mainly due to chromatid fragments, and the level of chromatid exchanges remained unchanged during the radiotherapy. The frequency variations of genome abnormalities, such as hyperploids and endoreplications, fluctuated in all patient groups. Concerning the polyploid cells, a significant difference at all stages of the study was observed in oncogynecological patients. The research of chromatid type aberrations and genome abnormalities showed some different features in changes of these parameters depending on tumor localization. The obtained data complemented the knowledge about the general cytogenetic status of cancer patients and are important for determining the influence of such a factor as tumor localization on the formation and dynamics of radiation-non-specific chromatid type lesions and genomic abnormalities during a radiotherapy course.

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Reproducibility test of radiomics using network analysis and Wasserstein K-means algorithm

10.1101/773168 ◽

2019 ◽

Author(s):

Jung Hun Oh ◽

Aditya P. Apte ◽

Evangelia Katsoulakis ◽

Nadeem Riaz ◽

Vaios Hatzoglou ◽

...

Keyword(s):

Lung Cancer ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Partial Correlation ◽

Wasserstein Distance ◽

Lung Cancer Patients ◽

Cancer Data ◽

Phantom Data

ABSTRACTPurposeTo construct robust and validated radiomic predictive models, the development of a reliable method that can identify reproducible radiomic features robust to varying image acquisition methods and other scanner parameters should be preceded with rigorous validation. Due to the property of high correlation present between radiomic features, we hypothesize that reproducible radiomic features across different datasets that are obtained from different image acquisition settings preserve some level of connectivity between features in the form of a network.MethodsWe propose a regularized partial correlation network to identify robust and reproducible radiomic features. This approach was tested on two radiomic feature sets generated with two different reconstruction methods from a cohort of 47 lung cancer patients. The commonality of the resulting two networks was assessed. A largest common network component from the two networks was tested on phantom data consisting of 5 cancer samples. We further propose a novel K-means algorithm coupled with the optimal mass transport (OMT) theory to cluster samples. This approach following the regularized partial correlation analysis was tested on computed tomography (CT) scans from 77 head and neck cancer patients that were downloaded from The Cancer Imaging Archive (TCIA) and validated on CT scans from 83 head and neck cancer patients treated at our institution.ResultsCommon radiomic features were found in relatively large network components between the resulting two partial correlation networks from a cohort of 47 lung cancer patients. The similarity of network components in terms of the common number of radiomic features was statistically significant. For phantom data, the Wasserstein distance on a largest common network component from the lung cancer data was much smaller than the Wasserstein distance on the same network using random radiomic features, implying the reliability of those radiomic features present in the network. Further analysis using the proposed Wasserstein K-means algorithm on TCIA head and neck cancer data showed that the resulting clusters separate tumor subsites and this was validated on our institution data.ConclusionsWe showed that a network-based analysis enables identifying reproducible radiomic features. This was validated using phantom data and external data via the Wasserstein distance metric and the proposed Wasserstein K-means method.

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Multimodal Guided Self-Help Exercise Program to Prevent Speech, Swallowing, and Shoulder Problems Among Head and Neck Cancer Patients: A Feasibility Study

Journal of Medical Internet Research ◽

10.2196/jmir.2990 ◽

2014 ◽

Vol 16 (3) ◽

pp. e74 ◽

Cited By ~ 28

Author(s):

Ingrid C Cnossen ◽

Cornelia F van Uden-Kraan ◽

Rico NPM Rinkel ◽

IJke J Aalders ◽

Cees JT de Goede ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Feasibility Study ◽

Neck Cancer ◽

Exercise Program ◽

Self Help

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Stepped care targeting psychological distress in head and neck cancer and lung cancer patients: which groups specifically benefit? Secondary analyses of a randomized controlled trial

Supportive Care in Cancer ◽

10.1007/s00520-019-04714-3 ◽

2019 ◽

Vol 27 (12) ◽

pp. 4543-4553 ◽

Cited By ~ 1

Author(s):

Femke Jansen ◽

Birgit I. Lissenberg-Witte ◽

Anna M. H. Krebber ◽

Pim Cuijpers ◽

Remco de Bree ◽

...

Keyword(s):

Lung Cancer ◽

Randomized Controlled Trial ◽

Head And Neck Cancer ◽

Psychological Distress ◽

Cancer Patients ◽

Controlled Trial ◽

Stepped Care ◽

Lung Cancer Patients ◽

Randomized Controlled ◽

Secondary Analyses

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Prospective, Longitudinal Quality-of-Life Study of Patients With Head and Neck Cancer: A Feasibility Study Including the EORTC QLQ-C30

Otolaryngology ◽

10.1016/s0194-5998(97)70246-8 ◽

1997 ◽

Vol 116 (6) ◽

pp. 666-673 ◽

Cited By ~ 76

Author(s):

Eva Hammerlid ◽

Kristin Bjordal ◽

Marianne Ahlner-ELMQVIST ◽

Magnus Jannert ◽

Stein Kaasa ◽

...

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Psychological Distress ◽

Pilot Study ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Eortc Qlq C30 ◽

Eortc Qlq

Despite modern advances in the treatment of head and neck cancer, the survival rate fails to improve. Considering the different treatment modalities involved, quality of life has been thought of as an additional end point criterion for use in clinical trials. A Nordic protocol to measure the quality of life of head and neck cancer patients before, during, and after treatment was established. Before the study, a pilot study was done with this protocol. The main purpose of this pilot study was to find out whether this cancer population would answer quality-pf-life questionnaires repeatedly (six times) over a 1-year period and whether the chosen questionnaires—a core questionnaire (European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30)), a tumor-specific questionnaire, and a psychological distress measure (Hospital Anxiety and Depression scale (HAD))—were sensitive for changes to functions and symptoms during the study year. The results presented in this article all refer to the pilot study. Forty-eight consecutive patients agreed to participate in the study. The most common tumor locations were the oral cavity (17) and the larynx (12). Almost all patients received combined treatment: 45 of 48 radiation therapy, 18 of 48 chemotherapy, and 17 of 48 surgery. After the primary treatment, 40 patients had complete tumor remission. Four of the 48 patients did not answer any questionnaires and were therefore excluded from the study. Of the remaining 44 patients, 3 died during the study year, and another 6 withdrew for various reasons. Thirty-five (85%) of the 41 patients alive at the 1-year follow-up answered all six questionnaires and thus completed the study. Mailed questionnaires were used throughout the study. All questionnaires were well accepted and found to be sensitive to changes during the study year. The greatest variability was found for symptoms and functions related specifically to head and neck cancer. The symptoms were swallowing difficulties, hoarse voice, sore mouth, dry mouth, and problems with taste. They all showed the same pattern, with an increase of symptoms during and just after finishing the treatment. The HAD scale revealed a high level of psychological distress, with 21% probable cases of psychiatric morbidity at diagnosis. In conclusion, it was shown that the study design and questionnaires were feasible for the forthcoming prospective quality-of-life assessment of Swedish and Norwegian head and neck cancer patients.

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Coping and psychological distress among head and neck cancer patients

Supportive Care in Cancer ◽

10.1007/s00520-010-1013-8 ◽

2010 ◽

Vol 19 (11) ◽

pp. 1735-1741 ◽

Cited By ~ 25

Author(s):

Hawazin W. Elani ◽

Paul J. Allison

Keyword(s):

Head And Neck Cancer ◽

Psychological Distress ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer

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A historical review of head and neck cancer in celebrities

The Journal of Laryngology & Otology ◽

10.1017/s0022215106004208 ◽

2006 ◽

Vol 121 (6) ◽

pp. 511-520 ◽

Cited By ~ 9

Author(s):

B J Folz ◽

A Ferlito ◽

N Weir ◽

L W Pratt ◽

A Rinaldo ◽

...

Keyword(s):

Risk Factors ◽

Lung Cancer ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Medical Literature ◽

Public Awareness ◽

Historical Review ◽

Term Survival

Introduction: The illnesses of celebrity patients always receive more attention from the general public than those of ordinary patients. With regard to cancer, this fact has helped to spread information about the four major malignancies: breast cancer, prostatic cancer, lung cancer and colorectal cancer. Head and neck cancer, on the other hand, is still not well recognised by the lay public, although the risk factors are similar to those of lung cancer. It was the objective of this analysis to identify cases of celebrity patients, the description of which could help to increase awareness of head and neck cancer, its symptoms and risk factors.Methods: The Internet and medical literature databases were searched for celebrity patients who had suffered from head and neck cancer.Results: The search revealed numerous famous head and neck cancer patients. However, only seven cases were documented well in the medical literature. Among the identified persons were one emperor, two United States presidents, a legendary composer, a world-renowned medical doctor, an outstanding athlete and an extraordinary entertainer. In spite of their exclusive position in society, these patients did not have a better prognosis compared with ordinary patients of their time. Only two of the group experienced long term survival and only one was cured. None of these influential figures used their influence to fund research or to promote knowledge about their respective diseases.Conclusion: The identified cases could help increase public awareness of head and neck cancer. Similar to activities in other oncologic fields, current celebrity head and neck cancer patients should be encouraged to discuss their diseases openly, which could have a positive effect on public health.

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