scholarly journals Routine cancer treatments and their impact on physical function, symptoms of cancer-related fatigue, anxiety, and depression

2022 ◽  
Author(s):  
Niklas Paul Grusdat ◽  
Alexander Stäuber ◽  
Marion Tolkmitt ◽  
Jens Schnabel ◽  
Birgit Schubotz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Treatment ◽  
Physical Function ◽  
Handgrip Strength ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Critical Threshold ◽  
Cancer Related Fatigue ◽  
Treatment Conditions

Abstract Background and purpose Breast cancer can be a major challenge for affected women. Knowledge of the physical function, symptoms of cancer-related fatigue, anxiety, and depression based on the cancer treatment may help to guide adequate support. Methods For this prospective observational study, we collected data from seventy-nine women with a mean age 54.6 ± 9.5 years prior to the onset of breast cancer treatment (T0) and after (T1/T2). Handgrip strength test (HGS), six-minute walk test (6MWT), the phase angle (PhA), the hospital anxiety and depression scale (HADS), and functional assessment of chronic illness therapy-fatigue (FACIT-F) were used to collect data from four treatment subgroups SC, surgery + chemotherapy; SCR, surgery + chemotherapy + radiation therapy; SR, surgery + radiation therapy; and S, surgery. Results A mixed ANOVA revealed a significant interaction between time and group for PhA, F = 8.55, p < 0.01; HGS, F = 3.59, p < 0.01; 6MWT, F = 4.47, p < 0.01; and FACIT-F, F = 2.77, p < 0.05 with most pronounced deterioration seen in group SCR (PhA 4.8°; HGS 27.5 kg, 6MWT 453.4 m, FACIT-F 33.8 points). HADS data displayed moderate anxiety and depression predominantly after treatment. Conclusion Our study showed that the extent of change in physical function, symptoms of fatigue, anxiety, and depression depends on the treatment conditions. The potentially higher risk of impaired function due to the prevalence of values below a critical threshold requires early initiated multidisciplinary support.

Imipridone (ONC201) and Radiation Therapy Combination Shows Promise in Breast Cancer Treatment

2018 ◽  
Vol 102 (3) ◽  
pp. e180-e181 ◽  
Author(s):  
S.R. Jhawar ◽  
A. Thandoni ◽  
S. Goyal ◽  
S.J. Wang ◽  
H. Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Treatment ◽  
Breast Cancer Treatment

scholarly journals Mediating effects of depression on anxiety and leisure constraints in patients with breast cancer

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Hsiu-Mei Huang ◽  
Jun-Hung Lai ◽  
Tsai-Wei Huang
Keyword(s):  
Breast Cancer ◽  
Leisure Activities ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Leisure Constraints ◽  
Daily Lives ◽  
Mediating Role ◽  
Patients Experience ◽  
The Relationship

Abstract Background Patients with breast cancer often exhibit high levels of anxiety and depression and a considerable decrease in their ability to participate in leisure activities, which result in the long-term disruption of their daily lives. This study intended to explore the relationships among anxiety, leisure constraints, and depression and evaluate whether depression mediates the effects of anxiety on leisure constraints in patients with breast cancer. Method This prospective study included 106 patients with breast cancer. All the patients completed the Taiwanese version of the Hospital Anxiety and Depression Scale and Leisure constraints questionnaire. Path analysis was used to test the mediating role of depression. Results Leisure constraints, anxiety, and depression were positively interrelated and co-occurred in the patients. The accelerated bootstrapping confidence intervals of the indirect effect did not include zero (0.276–1.663). Moreover, depression completely mediated the effects of anxiety on leisure constraints in patients with earlier cancer stages but not in patients with advanced cancer stages. Conclusions Depression is a crucial mechanism underlying the relationship between anxiety and leisure constraints in patients with breast cancer. Although many patients experience minimal disruption of activities and roles during survivorship, they are unable to perform functional activities and satisfactorily play their roles. This is the first study to explore leisure constraints in patients with breast cancer and investigate the mediating role of depression that underlies the relationship between anxiety and leisure constraints. The current findings are clinically crucial because they suggest the need to consider the simultaneous management of anxiety and depression for alleviating leisure constraints.

scholarly journals HOSPITAL ANXIETY AND DEPRESSION SCALE (HADS) OF OUTPATIENTS AFTER BREAST CANCER SURGERY

2005 ◽  
Vol 66 (1) ◽  
pp. 1-6
Author(s):  
Yuko TSUNODA ◽  
Eisuke FUKUMA ◽  
Kenji WADAMORI ◽  
Kunimoto HIGA ◽  
Jun-ichi SANUKI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Depression Scale ◽  
Cancer Surgery ◽  
Breast Cancer Surgery ◽  
Anxiety And Depression ◽  
Hospital Anxiety

Advanced Application of BNCT in Advanced Cancers

2009 ◽  
Author(s):  
Manuel L. Sztejnberg ◽  
Tatjana Jevremovic
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Boron Concentration ◽  
Breast Cancer Treatment ◽  
Breast Cancers ◽  
New Approach ◽  
Tolerance Dose ◽  
Boron Neutron Capture ◽  
Treatment Conditions ◽  
Higher Doses

We present a new concept of one form of radiation binary targeted therapy that may offer hope for the often fatal relapsed and/or metastasized HER2+ cancers. The idea is to deliver boronated (boron-10 isotope) anti-HER2 monoclonal antibodies (mAbs) to the patient to be deposited preferentially into the tumor followed by one session of a low energy neutron irradiation. Based on actual computed tomography data, we present the comprehensive theoretical (numerical) modeling of the new approach in designing the treatment conditions for the boron neutron capture therapy (BNCT) using the MITRII-FCB neutron beam facility. The results show the effectiveness of the proposed treatment option for the advanced breast cancers and the metastasized breast cancers in the lungs of a patient. Our theoretical analysis concludes that with a boron concentration of ∼316 μg/g in tumor and a tumor-to-healthy tissue boron concentration ratio of 35:1, this new BNCT breast cancer treatment can be performed with very low doses to normal tissue and 50 Gy, or higher, doses delivered to the tumor regions. In particular, when applied to the breast cancer treatment, the resulting doses to skin and lung remain under the tolerance dose values. We also went beyond the traditional application of the BNCT and analyzed its applicability in targeting the metastasized breast cancer; using the same theoretical approach we determined the doses delivered into the patient lung with scattered cancer loci.

Sign in / Sign up

Export Citation Format

Share Document