Cost-effectiveness of conservative versus surgical treatment strategies of lumbar spinal stenosis in the Swiss setting: analysis of the prospective multicenter Lumbar Stenosis Outcome Study (LSOS)

2016 ◽  
Vol 26 (2) ◽  
pp. 501-509 ◽  
Author(s):  
A. Aichmair ◽  
◽  
J. M. Burgstaller ◽  
M. Schwenkglenks ◽  
J. Steurer ◽  
...  
2010 ◽  
Vol 13 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Mark G. Burnett ◽  
Sherman C. Stein ◽  
Ronald H. M. A. Bartels

Object Standard treatment options for patients with lumbar spinal stenosis include nonoperative therapies as well as decompressive laminectomy. The introduction of interspinous decompression devices such as the X-STOP has broadened treatment options, but data comparing these treatment strategies are lacking. The object of this study was to provide a cost-effectiveness analysis of laminectomy, interspinous decompression, and nonoperative treatment for patients with lumbar stenosis. Methods The authors performed a structured literature review of lumbar stenosis and constructed a cost-effectiveness model. Using conservative treatment, decompressive laminectomy, and placement of X-STOP as the treatment arms, their primary analysis evaluated the optimal treatment strategy for a patient with lumbar stenosis at a 2-year time horizon. Secondary analyses were done to compare cases in which patients required single-level procedures with those in which multilevel procedures were required as well as to examine the outcomes for a 4-year time horizon. Outcomes were calculated using quality-adjusted life years and costs were considered from the perspective of society. Results Laminectomy was found to be the most effective treatment strategy, followed by X-STOP and then conservative treatment at a 2-year time horizon. Both surgical procedures were more costly than conservative treatment. Because laminectomy was both more effective and less costly than X-STOP, it is said to dominate overall. When single level procedures were considered alone, laminectomy was more effective but also more costly than X-STOP. Conclusions Lumbar laminectomy appears to be the most cost-effective treatment strategy for patients with symptomatic lumbar spinal stenosis.


Author(s):  
A. A. Afaunov ◽  
I. V. Basankin ◽  
A. V. Kuzmenko ◽  
V. K. Shapovalov ◽  
M. L. Mukhanov

Aim. Develop a pre-operative planning algorithm to treat patients with lumbar spinal stenosis of degenerative etiology.Material and methods. The results of surgical treatment of 522 patients at the age of 23-78 years with degenerative lumbar stenosis were analyzed. Patients with osteoporosis, with a sagittal spinal profile disorder or deviations in the frontal plane of more than 20 degrees, with spondylolistesis of more than 1 Meyerding degree, with accompanying pathology aggravating the Charlson Commorbidity Index of more than 8 points, were not included in this group. All patients underwent decompressive-stabilizing operations using TPF for 1 to 8 vertebral-motor segments (PDS). Decompression and interbody stabilization were performed by the method PLIF, TLIF, or by the method of reconstruction of the lumbar vertebral-motor segment (patent #2527150), or the ventral fusion was performed.Results. Immediate and distant results over a period of 24-36 months were studied by regression in major clinical manifestations. The VAS, McCulloch and Young scales, the Oswestry questionnaire, and the modified Macnab scale were applied. The quality of decompression, correction in operated PDS and intertose splicing were evaluated. The effect of the initial state of patients on the obtained results and the number of complications were studied as well. For this purpose, the correlation analysis was carried out between clinical parameters characterizing initial condition of patients (length of lumbar spinal stenosis, degree of functional maladaptation, duration of anamnesis and severity of premorbid background) and achieved results of treatment, as well as number of complications. A correlation analysis was also performed between the technique of performed operations and surgical tactics on the one hand and the achieved results and the number of complications on the other.Discussion. Differences in results and number of complications depending on the applied technical and tactical treatment options and statistical treatment with determination of the correlation coefficient of Spirman and Fisher's criterion determined clinical and spondylometric signs in the pre-operative state of patients, that influenced the probability of complications when using the specified technical and tactical treatment options. It has been found that the state of the premorbid background reliably affects the probability of the most dangerous intraoperative and early complications. The length of decompressive stabilizing operations affects the probability of evidence for audits in the distant period. When performing TLIF, the spondylolistesis presence increases the likelihood of intraoperative liquvorea. The method of lumbar vertebral-motor segment reconstruction in lumbar lordosis deficiency improves the possibility of correction in operated PDS in comparison with TLIF technique.Conclusion. Taking into account the revealed statistically confirmed effect of a number of clinical and spondylometric signs of the pre-operative condition in patients on the probability of complications using various technical and tactical versions of treatment, an algorithm of pre-operative planning of surgical intervention in patients with lumbar stenosis of degenerative etiology is presented.


BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e030578
Author(s):  
Konstantinos Pazarlis ◽  
Anna Punga ◽  
Nikos Schizas ◽  
Bengt Sandén ◽  
Karl Michaëlsson ◽  
...  

IntroductionSymptomatic lumbar spinal stenosis is the most common indication for spinal surgery. However, more than one-third of the patients undergoing surgery for lumbar stenosis report dissatisfaction with the results. On the other hand, conservative treatment has shown positive results in some cases. This trial will compare the outcomes of surgical versus non-surgical treatment for lumbar stenosis. The study includes a multidimensional follow-up, aiming to study the association between outcome and other studied parameters, mainly electromyography and nerve conduction. Moreover, it may contribute to a better understanding of the pathophysiology of lumbar stenosis and to the development of future pharmacological treatments.Methods and analysisUppSten is a single-centre randomised controlled trial in which 150 patients with symptomatic lumbar spinal stenosis will be randomised into one of two treatment arms. The patients in the surgical arm will undergo laminectomy; the patients in the non-surgical arm will be given a structured physical training programme. The primary outcome of the study will be the Oswestry Disability Index. Secondary outcomes will include motor amplitude and degree of denervation activity obtained by means of nerve conduction studies and electromyography. Patient-reported outcome measures will be also used as secondary outcomes. Blood sample analysis and the investigation of potential inflammation markers are the additional secondary outcome parameters. Laboratory evaluation will include blood sample collection before the treatment initiation and after 6 months. Flavum ligament biopsies will be performed in the surgical group. Finally, tertiary outcomes will include neurophysiological measures, the objective walking ability and radiological evaluation.Ethics and disseminationThe study is approved by the Local Ethics Committee (Dnr 2017–506), the Hospital’s Clinical Trials Committee (2018–0001) and the National Biobank Council and Uppsala Biobank (BbA-827-2018-025). The results will be presented in peer-reviewed journals and at international conferences.Trial registration numberNCT03495661


2000 ◽  
Vol 9 (6) ◽  
pp. 563-570 ◽  
Author(s):  
M. Cornefjord ◽  
G. Byröd ◽  
H. Brisby ◽  
B. Rydevik

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