3D-printed navigation template in cervical spine fusion: a systematic review and meta-analysis

Abstract INTRODUCTION There has been a steady increase in spinal fusion procedures performed each year in the US, especially cervical and lumbar fusion. Our study aims to analyze the rate of increase at low-, medium-, and high-volume hospitals, and socioeconomic characteristics of the patient populations at these three volume categories. METHODS We searched the New York State, Statewide Planning and Research Cooperative System (SPARCS) database from 2005 to 2014 for the ICD-9-CM Procedure Codes 81.01 (Fusion, atlas-axis), 81.02 (Fusion, anterior column, other cervical, anterior technique), and 81.03 (Fusion, posterior column, other cervical, posterior technique). Patients' primary diagnosis (ICD-9-CM), age, race/ethnicity, primary payment method, severity of illness, length of stay, hospital of operation were included. We categorized all 122 hospitals high-, medium-, and low-volume. We then described the trends in annual number of cervical spine fusion surgeries in each of the three hospital volume groups using descriptive statistics. RESULTS >African American patients were significantly greater portion of patients receiving care at low-volume hospitals, 15.1% versus 11.6% at high-volume hospital. Medicaid and self-pay patients were also overrepresented at low-volume centers, 6.7% and 3.9% versus 2.6% and 1.7% respectively at high-volume centers. In addition, Compared with Caucasian patients, African American patients had higher rates of post-operative infection (P = 0.0020) and post-operative bleeding (P = 0.0044). Compared with privately insured patients, Medicaid patients had a higher rate of post-operative bleeding (P = 0.0266) and in-hospital mortality (P = 0.0031). CONCLUSION Our results showed significant differences in racial distribution and primary payments methods between the low- and high-volume categories, and suggests that accessibility to care at high-volume centers remains problematic for these disadvantaged populations.

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Adjacent Segment Disease After Cervical Spine Fusion

Spine ◽

10.1097/brs.0000000000002377 ◽

2018 ◽

Vol 43 (9) ◽

pp. 605-609 ◽

Cited By ~ 19

Author(s):

Mohamed Alhashash ◽

Mootaz Shousha ◽

Heinrich Boehm

Keyword(s):

Cervical Spine ◽

Spine Fusion ◽

Adjacent Segment Disease ◽

Adjacent Segment ◽

Cervical Spine Fusion

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79. Anterior cervical spine fusion using bioresorbable interbody spacers and rhBMP-2

The Spine Journal ◽

10.1016/j.spinee.2004.05.080 ◽

2004 ◽

Vol 4 (5) ◽

pp. S41-S42 ◽

Cited By ~ 2

Author(s):

Todd Lanman ◽

Theodore Goldstein ◽

Thomas Hopkins

Keyword(s):

Cervical Spine ◽

Spine Fusion ◽

Cervical Spine Fusion

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Autologous Stem Cells in Cervical Spine Fusion

Global Spine Journal ◽

10.1177/2192568220948479 ◽

2020 ◽

pp. 219256822094847

Author(s):

Patrick C. Hsieh ◽

Andrew S. Chung ◽

Darrel Brodke ◽

Jong-Beom Park ◽

Andrea C. Skelly ◽

...

Keyword(s):

Stem Cells ◽

Bone Marrow ◽

Cervical Spine ◽

Bone Marrow Aspirate ◽

A Priori ◽

Case Series ◽

Fusion Rate ◽

Spine Fusion ◽

Retrospective Cohort Studies ◽

Cervical Spine Fusion

Study Design: Systematic review. Objectives: To systematically review, critically appraise and synthesize evidence on use of stem cells from autologous stem cells from bone marrow aspirate, adipose, or any other autologous sources for fusion in the cervical spine compared with other graft materials. Methods: A systematic search of PubMed/MEDLINE was conducted for literature published through October 31, 2018 and through February 20, 2020 for EMBASE and ClinicalTrials.gov comparing autologous cell sources for cervical spine fusion to other graft options. Results: From 36 potentially relevant citations identified, 10 studies on cervical fusion met the inclusion criteria set a priori. Two retrospective cohort studies, one comparing cancellous bone marrow (CBM) versus hydroxyapatite (HA) and the other bone marrow aspirate (BMA) combined with autograft and HA versus autograft and HA alone, were identified. No statistical differences were seen between groups in either study for improvement in function, symptoms, or fusion; however, in the study evaluating BMA, the authors reported a statistically greater fusion rate and probability of fusion over time in the BMA versus the non-BMA group. Across case series evaluating BMA, authors reported improved function and pain and fusion ranged from 84% to 100% across the studies. In general, complications were poorly reported. Conclusions: The overall quality (strength) of evidence of effectiveness and safety of autologous BMA for cervical arthrodesis in the current available literature was very low. Based on currently available data, firm conclusions regarding the effectiveness or safety of BMA in cervical fusions cannot be made.

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Union Rate and Complications in Spine Fusion with Recombinant Human Bone Morphogenetic Protein-7: Systematic Review and Meta-Analysis

Global Spine Journal ◽

10.1055/s-0035-1557143 ◽

2015 ◽

Vol 6 (2) ◽

pp. 124-132

Author(s):

Julia Vavken ◽

Patrick Vavken ◽

Alexander Mameghani ◽

Stefan Schaeren

Keyword(s):

Systematic Review ◽

Bone Morphogenetic Protein ◽

Meta Analysis ◽

Spine Fusion ◽

Human Bone ◽

Union Rate ◽

Bone Morphogenetic Protein 7 ◽

Morphogenetic Protein ◽

Human Bone Morphogenetic Protein ◽

Recombinant Human Bone

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Does Obesity Correlate with Postoperative Complications After Elective Posterior Cervical Spine Fusion?

World Neurosurgery ◽

10.1016/j.wneu.2020.05.083 ◽

2020 ◽

Vol 141 ◽

pp. e231-e238

Author(s):

Nida Fatima ◽

Elie Massaad ◽

Christopher Alvarez-Breckenridge ◽

John E. Berry Candelario ◽

Muhamed Hadzipasic ◽

...

Keyword(s):

Cervical Spine ◽

Postoperative Complications ◽

Spine Fusion ◽

Cervical Spine Fusion

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3D printed bone models in oral and cranio-maxillofacial surgery: a systematic review

3D Printing in Medicine ◽

10.1186/s41205-020-00082-5 ◽

2020 ◽

Vol 6 (1) ◽

Cited By ~ 1

Author(s):

Matteo Meglioli ◽

Adrien Naveau ◽

Guido Maria Macaluso ◽

Sylvain Catros

Keyword(s):

Systematic Review ◽

Fused Deposition Modeling ◽

Haptic Feedback ◽

Treatment Time ◽

Data Extraction ◽

Meta Analysis ◽

Maxillofacial Surgery ◽

Patient Specific ◽

Fused Deposition ◽

3D Printed

Abstract Aim This systematic review aimed to evaluate the use of three-dimensional (3D) printed bone models for training, simulating and/or planning interventions in oral and cranio-maxillofacial surgery. Materials and methods A systematic search was conducted using PubMed® and SCOPUS® databases, up to March 10, 2019, by following the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) protocol. Study selection, quality assessment (modified Critical Appraisal Skills Program tool) and data extraction were performed by two independent reviewers. All original full papers written in English/French/Italian and dealing with the fabrication of 3D printed models of head bone structures, designed from 3D radiological data were included. Multiple parameters and data were investigated, such as author’s purpose, data acquisition systems, printing technologies and materials, accuracy, haptic feedback, variations in treatment time, differences in clinical outcomes, costs, production time and cost-effectiveness. Results Among the 1157 retrieved abstracts, only 69 met the inclusion criteria. 3D printed bone models were mainly used as training or simulation models for tumor removal, or bone reconstruction. Material jetting printers showed best performance but the highest cost. Stereolithographic, laser sintering and binder jetting printers allowed to create accurate models with adequate haptic feedback. The cheap fused deposition modeling printers exhibited satisfactory results for creating training models. Conclusion Patient-specific 3D printed models are known to be useful surgical and educational tools. Faced with the large diversity of software, printing technologies and materials, the clinical team should invest in a 3D printer specifically adapted to the final application.

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