The combination of the serum carbohydrate antigen 19-9 and carcinoembryonic antigen is a simple and accurate predictor of mortality in pancreatic cancer patients

Surgery Today ◽  
2013 ◽  
Vol 44 (9) ◽  
pp. 1692-1701 ◽  
Author(s):  
Mitsuro Kanda ◽  
Tsutomu Fujii ◽  
Hideki Takami ◽  
Masaya Suenaga ◽  
Yoshikuni Inokawa ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Carcinoembryonic Antigen ◽  
Cancer Patients ◽  
Carbohydrate Antigen ◽  
Accurate Predictor ◽  
Serum Carbohydrate Antigen

scholarly journals Prediction of Postoperative Early Recurrence and Prognosis in Pancreatic Cancer Patients

2017 ◽  
Vol 102 (5-6) ◽  
pp. 272-277
Author(s):  
Hiroshi Kurahara ◽  
Kosei Maemura ◽  
Yuko Mataki ◽  
Masahiko Sakoda ◽  
Satoshi Iino ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Tumor Size ◽  
Early Recurrence ◽  
Carbohydrate Antigen ◽  
Additional Risk ◽  
Reactive Protein ◽  
Serum Carbohydrate Antigen ◽  
Improve Patient

Background: Stratification of pancreatic cancer patients based on early recurrence and prognosis is essential for selecting optimal therapeutic strategies. The aim of this study was to investigate whether serum carbohydrate antigen (CA) 19-9 levels can be better used to predict early recurrence and prognosis. Methods: Patients whose CA 19-9 levels obtained in association with total bilirubin >2.0 mg/dL and whose CA 19-9 levels <5.0 U/mL were excluded to avoid the influence of obstructive jaundice and Lewis phenotype Lea−b−, respectively. A total of 125 pancreatic cancer patients who underwent surgical resection were enrolled. Results: Larger tumor size, higher serum CA 19-9 level, higher C-reactive protein (CRP) level, more advanced T status, and lymph node metastasis were significantly associated with recurrence within 1 year after surgery (early recurrence). The rate of early recurrence in patients with CA 19-9 levels >100 U/mL (76.9%) was significantly higher than that of patients with CA 19-9 levels ≤100 U/mL (27.9%). We performed combination analysis of 2 additional risk factors, CRP level (cutoff: 1.0 mg/dL) and tumor size (cutoff: 3.0 cm), with serum CA 19-9 level (cutoff: 100 U/mL). Patients were divided into 3 groups according to their number of risk factors. Rates of early recurrence in patients with 0, 1, and 2 or 3 risk factors were 22.0%, 45.2%, and 91.7%, respectively. Moreover, overall survival was significantly different in each group. Conclusion: Serum CA 19-9 level, in addition to CRP level and tumor size, improve patient stratification in early recurrence as well as prognosis.

Predictive Value of Serum Carbohydrate Antigen 19-9 (CA19-9) for Early Mortality in Advanced Pancreatic Cancer

2017 ◽  
Vol 49 (4) ◽  
pp. 481-486 ◽  
Author(s):  
Pedro L. S. Usón Junior ◽  
Donato Callegaro-Filho ◽  
Diogo D. G. Bugano ◽  
Fernando Moura ◽  
Fernando C. Maluf
Keyword(s):  
Pancreatic Cancer ◽  
Predictive Value ◽  
Advanced Pancreatic Cancer ◽  
Carbohydrate Antigen ◽  
Early Mortality ◽  
Serum Carbohydrate Antigen

scholarly journals The value of preoperative carcinoembryonic antigen and cancer antigen 19-9 blood levels as predictive factors for irresectability in pancreatic cancer patients

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S556
Author(s):  
L. van Manen ◽  
J. Groen ◽  
A. Vahrmeijer ◽  
R.J. Swijnenburg ◽  
B. Bonsing ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Carcinoembryonic Antigen ◽  
Cancer Patients ◽  
Predictive Factors ◽  
Blood Levels ◽  
Cancer Antigen

Early decrement of serum carbohydrate antigen 19-9 predicts favorable outcome in advanced pancreatic cancer

2016 ◽  
Vol 31 (2) ◽  
pp. 506-512 ◽  
Author(s):  
Kwang Hyun Chung ◽  
Ji Kon Ryu ◽  
Ban Seok Lee ◽  
Dong Kee Jang ◽  
Sang Hyub Lee ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Advanced Pancreatic Cancer ◽  
Carbohydrate Antigen ◽  
Favorable Outcome ◽  
Serum Carbohydrate Antigen
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