An Evaluation of Malignancy and Prognostic Factors Based on Mode of Lymph Node Metastasis in Esophageal Carcinoma

Surgery Today ◽  
1999 ◽  
Vol 29 (11) ◽  
pp. 1131-1135 ◽  
Author(s):  
Daisuke Tachikawa ◽  
Shigemitsu Inada ◽  
Tsuyoshi Kotoh ◽  
Kitaro Futami ◽  
Sumitaka Arima ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Esophageal Carcinoma ◽  
Node Metastasis

An evaluation of malignancy and prognostic factors based on mode of lymph node metastasis in esophageal carcinoma

Surgery Today ◽  
1999 ◽  
Vol 29 (11) ◽  
pp. 1131-1135 ◽  
Author(s):  
Daisuke Tachikawa ◽  
Shigemitsu Inada ◽  
Tsuyoshi Kotoh ◽  
Kitaro Futami ◽  
Sumitaka Arima ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Esophageal Carcinoma ◽  
Node Metastasis

scholarly journals The role of microvessel density, lymph node metastasis, and tumor size as prognostic factors of distant metastasis in colorectal cancer

2017 ◽  
Vol 13 (6) ◽  
pp. 4327-4333 ◽  
Author(s):  
Tomonari Cho ◽  
Eisuke Shiozawa ◽  
Fumihiko Urushibara ◽  
Nana Arai ◽  
Toshitaka Funaki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Distant Metastasis ◽  
Microvessel Density ◽  
Tumor Size ◽  
Node Metastasis

scholarly journals Prognostic factors in thyroid cancer patients following surgical resection: a retrospective study of optimal care strategies for postoperative complications

2020 ◽  
Author(s):  
Hiroki Konno
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Hospital Stay ◽  
Patient Group ◽  
Calcium Metabolism ◽  
Cervical Lymph Node ◽  
Length Of Hospital Stay ◽  
Cervical Lymph Node Metastasis ◽  
Node Metastasis

Abstract Background : This study analyzed the effects of four candidate prognostic factors on length of hospital stay among inpatients following thyroid cancer resection; specifically, age ≥ 45 years, cervical lymph node metastasis, impaired calcium metabolism, and postoperative hypothyroidism.Methods : This was a retrospective study reviewing 434 patients’ medical and claim records (n=434; male 21.0%/female 79.0%, age: 57.31±13.52). Results : Patients who met one of the four prognostic criteria were more likely to have a longer hospital stay using acute-care beds than corresponding cases negative for these criteria. Regression analysis indicated that patient’s length of hospital stay was increased with each factor by the following rates: 1) 14.57% if 45 years or older, 2) 26.24% if positive for cervical lymph node metastasis, 3) 28.79% if positive for impaired calcium metabolism, and 4) 29.95% if positive for postoperative hypothyroidism. Moreover, estimations of cumulative probability of length of hospital stay indicate that: 1) 26.6% of the age≥45 patient group is expected to be discharged by the 7 th day in contrast to 42.9% of age<45 patient group (91.0%,97.4% at 14 th day); 2) 16.1% of the cervical lymph node metastasis patient group is expected to be discharged by the 7 th day in contrast with 30.5% of non-patient group (83.9%,92.8% at 14 th day); 3) 14.8% of the impaired calcium metabolism patient group is expected to be discharged by the 7 th day in contrast with 30.5% of non-patient group (70.4%,93.6% at 14 th day), and 4) 21.4% of the postoperative hypothyroidism patient group is expected to be discharged by the 7 th day in contrast with 29.8% of non-patient group (71.4%,92.9% at 14 th day). Conclusions : Disorders of calcium metabolism and postoperative hypothyroidism were the most likely postoperative complications to occur, yet these are not identified as prognostic factors in the Diagnosis Procedure Combination / Per-Diem Payment System (DPC/PDPS) framework in Japan. The findings suggest that patients with these two conditions should receive care in beds of a lower, sub-acute category, and they should be quickly transferred to such beds or, if possible, to outpatient care.

Prognostic Factors and Lymph Node Metastasis Patterns of Primary Duodenal Cancer

2021 ◽  
Author(s):  
Kohei Nishio ◽  
Kenjiro Kimura ◽  
Shimpei Eguchi ◽  
Daisuke Shirai ◽  
Jun Tauchi ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Duodenal Cancer ◽  
Node Metastasis ◽  
Metastasis Patterns

scholarly journals Prognostic Factors in Canine Mammary Carcinomas and HER2 Expression Relationship

2017 ◽  
Vol 45 (1) ◽  
pp. 9 ◽  
Author(s):  
Nicolle Pereira Soares ◽  
Alessandra Aparecida Medeiros ◽  
Igor De Paula Castro ◽  
Taís Meziara Wilson ◽  
Taís De Almeida Moreira ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Histological Grade ◽  
Her2 Expression ◽  
Mammary Carcinomas ◽  
Node Metastasis ◽  
In Situ Carcinoma ◽  
Grade Iii

Background: The human epidermal growth factor type 2 (HER2) receptor is a membrane glycoprotein tyrosine kinase. In woman, HER2 expression is diagnosed in 30% of breast carcinomas and it is associated with a worse prognosis, higher rate of recurrence and mortality. In the bitch, the HER2 overexpression in canine mammary tumors is still controversial and the prognostic value remains uncertain. Thus, we aimed to verify the HER2 expression in canine mammary carcinomas and relate it to the type and histological grade, lymph node metastasis and clinical staging.Materials, Methods & Results: Ninety bitches diagnosed with mammary carcinoma were included in this study. The inclusion criteria were bitches with complete clinical examination, thoracic radiographic examination and submitted unilateral or bilateral mastectomy. Ninety-nine samples of mammary carcinoma were used and the fragments of tumor and regional lymph nodes were fixed in 10% neutral formalin for histopathological and immunohistochemistry analysis. The lesions were evaluated by two pathologists and classified according to the type and histological grade. HER2 expression was performed by semi-quantitative analysis of the slides according to the HerceptTestTM (Dako) recommended score. Simple carcinomas were the most frequent (51.51%) followed by complex carcinomas (46.47%) and in situ carcinoma (2.02%). The histological grade of 97 carcinoma samples was attributed, except in situ carcinoma, 37 (38.14%) of the neoplasms were grade I, 50 (51.55%) grade II and only 10 (10.31%) tumors were classified as grade III. Forty bitches were submitted to clinical staging (TNM) and 42.50% of the bitches received staging in grade I and, 25% of the bitches staged in grade IV and V, with metastases. The HER2 expression, 13/99 samples (13.13%) received score +2, 19/99 (19.19%) score +1 and absence of marking (score 0) was identified in 67 samples (67.80 %). Immunostaining in hyperplastic or normal epithelial cells was evidenced, often in association with weak or moderate cytoplasmic labeling. Of the samples expressing +2 score for HER2 (n = 13), eight samples (17.39%) were complex carcinoma and five (9.80%) simple carcinomas. There was no relationship between HER2 immunostaining with age, tumor size, TNM, histological type, histological gradation, lymph node metastasis and distance. Animals with lymph node metastasis, as well as those diagnosed with distant metastasis, did not present HER2 expression in the tumors.Discussion: The simple carcinoma seems to be the most frequent type histological diagnosed in canine mammary carcinomas, followed by carcinoma in mixed tumor and complex carcinoma. Tubulopapillary carcinomas are more invasive in the female dogs as well as in the woman. Carcinomas grade I and II are more frequent and present a better prognosis for the dog. However, bitches with grade III carcinoma survived for a shorter time when compared to dogs with grade I or II tumors. A factor that may have contributed to the lower number of bitches at worst prognostic stage (EC IV and V) is the current owners’ awareness that they have sought veterinary help earlier, as soon as they detect small nodules in mammary gland. Overexpression of HER2 in women breast cancer is diagnosed in 20-30% of cases, whereas in bitches, this expression is variable. Also the different percentages of canine HER2 immunostaining are due to the lack of standardization for the analysis of the immunostaining, the immunohistochemical techniques employed and the non-specificity of the HER2 antibody. In canine mammary carcinomas the HER2 expression in low and this immunostaining is not related to other established prognostic factors. This study reinforces the hypothesis put forward by other authors that in the bitch the expression of HER2 may not be related to malignancy and tumor progression.

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