Multi-walled carbon nanotubes (MWNTs) combining with ferroferric oxide (Fe3O4) nanoparticles were used for electrochemical determination of bisphenol A (BPA). Fe3O4 nanoparticles with an average size of about 12 nm were synthesized. It was found that the Fe3O4-MWNTs nanocomposites-modified electrode could remarkably enhance the oxidation current of BPA. Chronoamperometry studies reveal that the amperometric response is rapid, stable, and offers a linear dependence over a range of BPA concentrations from 0.1 to 4 M. The proposed method can be used for evaluation of BPA in water samples. The electrochemical properties of the Fe3O4-MWNT nanocomposites are reasonably envisaged to be promising for providing a nanostructured platform in the development of electrochemical sensors or biosensors.