Guanine (G) oxidation products, such as 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-oxo-guanine (8-OXOG), have been widely studied as promising biomarkers for DNA oxidative damage.
Screening results indicated that DCO-5 exhibited the highest sensitivity to viscosity and was insensitive to polarity or pH, and enables the successful detection of viscosity changes in vivo.
A novel and simple turn-on fluorescent probe bearing NBD and benzaldehyde fragments for the rapid optical sensing of biothiols has been designed and synthesized.