Altered functional organization of the motor system related to ankle movements in Parkinson’s disease: insights from functional MRI

2011 ◽  
Vol 118 (5) ◽  
pp. 783-793 ◽  
Author(s):  
Petra Katschnig ◽  
Petra Schwingenschuh ◽  
Margit Jehna ◽  
Martin Švehlík ◽  
Katja Petrovic ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Motor System ◽  
Functional Organization

FV2. Cognition-related Parkinson’s disease pattern with functional MRI: Validation and clinical correlates

2018 ◽  
Vol 129 (8) ◽  
pp. e48-e50
Author(s):  
K.A. Schindlbeck ◽  
A. Vo ◽  
K. Fujita ◽  
P.J. Mattis ◽  
F. Marzinzik ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Clinical Correlates ◽  
Disease Pattern

scholarly journals A functional MRI study of automatic movements in patients with Parkinson's disease

Brain ◽  
2005 ◽  
Vol 128 (10) ◽  
pp. 2250-2259 ◽  
Author(s):  
Tao Wu ◽  
Mark Hallett
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Mri Study

scholarly journals Differential effects of deep brain stimulation and levodopa on brain activity in Parkinson’s disease

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Karsten Mueller ◽  
Dušan Urgošík ◽  
Tommaso Ballarini ◽  
Štefan Holiga ◽  
Harald E Möller ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Functional Mri ◽  
Brain Stimulation ◽  
Significant Interaction ◽  
Brain Activity ◽  
Finger Tapping ◽  
Levodopa Treatment ◽  
Deep Brain

Abstract Levodopa is the first-line treatment for Parkinson’s disease, although the precise mechanisms mediating its efficacy remain elusive. We aimed to elucidate treatment effects of levodopa on brain activity during the execution of fine movements and to compare them with deep brain stimulation of the subthalamic nuclei. We studied 32 patients with Parkinson’s disease using functional MRI during the execution of finger-tapping task, alternating epochs of movement and rest. The task was performed after withdrawal and administration of a single levodopa dose. A subgroup of patients (n = 18) repeated the experiment after electrode implantation with stimulator on and off. Investigating levodopa treatment, we found a significant interaction between both factors of treatment state (off, on) and experimental task (finger tapping, rest) in bilateral putamen, but not in other motor regions. Specifically, during the off state of levodopa medication, activity in the putamen at rest was higher than during tapping. This represents an aberrant activity pattern probably indicating the derangement of basal ganglia network activity due to the lack of dopaminergic input. Levodopa medication reverted this pattern, so that putaminal activity during finger tapping was higher than during rest, as previously described in healthy controls. Within-group comparison with deep brain stimulation underlines the specificity of our findings with levodopa treatment. Indeed, a significant interaction was observed between treatment approach (levodopa, deep brain stimulation) and treatment state (off, on) in bilateral putamen. Our functional MRI study compared for the first time the differential effects of levodopa treatment and deep brain stimulation on brain motor activity. We showed modulatory effects of levodopa on brain activity of the putamen during finger movement execution, which were not observed with deep brain stimulation.

scholarly journals Parkinson's disease-related network topographies characterized with resting state functional MRI

2016 ◽  
Vol 38 (2) ◽  
pp. 617-630 ◽  
Author(s):  
An Vo ◽  
Wataru Sako ◽  
Koji Fujita ◽  
Shichun Peng ◽  
Paul J. Mattis ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Resting State

scholarly journals Understanding Parkinson’s disease and deep brain stimulation: Role of monkey models

2019 ◽  
Vol 116 (52) ◽  
pp. 26259-26265 ◽  
Author(s):  
Jerrold L. Vitek ◽  
Luke A. Johnson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Basal Ganglia ◽  
Medical Therapy ◽  
Brain Stimulation ◽  
Functional Organization ◽  
Surgical Approaches ◽  
Drug Induced ◽  
Deep Brain

Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder affecting over 10 million people worldwide. In the 1930s and 1940s there was little understanding regarding what caused PD or how to treat it. In a desperate attempt to improve patients’ lives different regions of the neuraxis were ablated. Morbidity and mortality were common, but some patients’ motor signs improved with lesions involving the basal ganglia or thalamus. With the discovery ofl-dopa the advent of medical therapy began and surgical approaches became less frequent. It soon became apparent, however, that medical therapy was associated with side effects in the form of drug-induced dyskinesia and motor fluctuations and surgical therapies reemerged. Fortunately, during this time studies in monkeys had begun to lay the groundwork to understand the functional organization of the basal ganglia, and with the discovery of the neurotoxin MPTP a monkey model of PD had been developed. Using this model scientists were characterizing the physiological changes that occurred in the basal ganglia in PD and models of basal ganglia function and dysfunction were proposed. This work provided the rationale for the return of pallidotomy, and subsequently deep brain stimulation procedures. In this paper we describe the evolution of these monkey studies, how they provided a greater understanding of the pathophysiology underlying the development of PD and provided the rationale for surgical procedures, the search to understand mechanisms of DBS, and how these studies have been instrumental in understanding PD and advancing the development of surgical therapies for its treatment.

Utilising functional MRI (fMRI) to explore the freezing phenomenon in Parkinson’s disease

2011 ◽  
Vol 18 (6) ◽  
pp. 807-810 ◽  
Author(s):  
James M. Shine ◽  
Philip B. Ward ◽  
Sharon L. Naismith ◽  
Mark Pearson ◽  
Simon J.G. Lewis
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri

Functional MRI in the assessment of cortical activation in subjects with Parkinson’s disease

2006 ◽  
Vol 111 (1) ◽  
pp. 104-115 ◽  
Author(s):  
M. Ukmar ◽  
C. Furlan ◽  
R. Moretti ◽  
G. Garbin ◽  
P. Torre ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Cortical Activation

Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease

2004 ◽  
Vol 14 (4) ◽  
pp. 686-690 ◽  
Author(s):  
Bettina Sorger ◽  
Ralf Girnus ◽  
Oliver Schulte ◽  
Barbara Krug ◽  
Klaus Lackner ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Functional Mri ◽  
Brain Stimulation ◽  
New Approach ◽  
Deep Brain

Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease

2008 ◽  
Vol 23 (S3) ◽  
pp. S548-S559 ◽  
Author(s):  
Jose A. Obeso ◽  
Maria Cruz Rodríguez-Oroz ◽  
Beatriz Benitez-Temino ◽  
Franscisco J. Blesa ◽  
Jorge Guridi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Functional Organization ◽  
Therapeutic Implications

Cerebral basis of visual hallucinations in Parkinson's disease: Structural and functional MRI studies

2011 ◽  
Vol 310 (1-2) ◽  
pp. 79-81 ◽  
Author(s):  
Naroa Ibarretxe-Bilbao ◽  
Carme Junque ◽  
Maria J. Marti ◽  
Eduardo Tolosa
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Visual Hallucinations ◽  
Mri Studies
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