Functional MRI in the assessment of cortical activation in subjects with Parkinson’s disease

2006 ◽  
Vol 111 (1) ◽  
pp. 104-115 ◽  
Author(s):  
M. Ukmar ◽  
C. Furlan ◽  
R. Moretti ◽  
G. Garbin ◽  
P. Torre ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Cortical Activation

FV2. Cognition-related Parkinson’s disease pattern with functional MRI: Validation and clinical correlates

2018 ◽  
Vol 129 (8) ◽  
pp. e48-e50
Author(s):  
K.A. Schindlbeck ◽  
A. Vo ◽  
K. Fujita ◽  
P.J. Mattis ◽  
F. Marzinzik ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Clinical Correlates ◽  
Disease Pattern

scholarly journals A functional MRI study of automatic movements in patients with Parkinson's disease

Brain ◽  
2005 ◽  
Vol 128 (10) ◽  
pp. 2250-2259 ◽  
Author(s):  
Tao Wu ◽  
Mark Hallett
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Mri Study

scholarly journals Differential effects of deep brain stimulation and levodopa on brain activity in Parkinson’s disease

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Karsten Mueller ◽  
Dušan Urgošík ◽  
Tommaso Ballarini ◽  
Štefan Holiga ◽  
Harald E Möller ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Functional Mri ◽  
Brain Stimulation ◽  
Significant Interaction ◽  
Brain Activity ◽  
Finger Tapping ◽  
Levodopa Treatment ◽  
Deep Brain

Abstract Levodopa is the first-line treatment for Parkinson’s disease, although the precise mechanisms mediating its efficacy remain elusive. We aimed to elucidate treatment effects of levodopa on brain activity during the execution of fine movements and to compare them with deep brain stimulation of the subthalamic nuclei. We studied 32 patients with Parkinson’s disease using functional MRI during the execution of finger-tapping task, alternating epochs of movement and rest. The task was performed after withdrawal and administration of a single levodopa dose. A subgroup of patients (n = 18) repeated the experiment after electrode implantation with stimulator on and off. Investigating levodopa treatment, we found a significant interaction between both factors of treatment state (off, on) and experimental task (finger tapping, rest) in bilateral putamen, but not in other motor regions. Specifically, during the off state of levodopa medication, activity in the putamen at rest was higher than during tapping. This represents an aberrant activity pattern probably indicating the derangement of basal ganglia network activity due to the lack of dopaminergic input. Levodopa medication reverted this pattern, so that putaminal activity during finger tapping was higher than during rest, as previously described in healthy controls. Within-group comparison with deep brain stimulation underlines the specificity of our findings with levodopa treatment. Indeed, a significant interaction was observed between treatment approach (levodopa, deep brain stimulation) and treatment state (off, on) in bilateral putamen. Our functional MRI study compared for the first time the differential effects of levodopa treatment and deep brain stimulation on brain motor activity. We showed modulatory effects of levodopa on brain activity of the putamen during finger movement execution, which were not observed with deep brain stimulation.

scholarly journals Parkinson's disease-related network topographies characterized with resting state functional MRI

2016 ◽  
Vol 38 (2) ◽  
pp. 617-630 ◽  
Author(s):  
An Vo ◽  
Wataru Sako ◽  
Koji Fujita ◽  
Shichun Peng ◽  
Paul J. Mattis ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri ◽  
Resting State

fMRI changes in cortical activation during task performance with the unaffected hand partially reverse after ropinirole treatment in de novo Parkinson's disease

2013 ◽  
Vol 19 (2) ◽  
pp. 265-268 ◽  
Author(s):  
Carlo Tessa ◽  
Stefano Diciotti ◽  
Claudio Lucetti ◽  
Filippo Baldacci ◽  
Paolo Cecchi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Task Performance ◽  
De Novo ◽  
Cortical Activation

Is Cortical Activation During Walking Different Between Parkinson’s Disease Motor Subtypes?

2020 ◽  
Author(s):  
Diego Orcioli-Silva ◽  
Rodrigo Vitório ◽  
Victor Spiandor Beretta ◽  
Núbia Ribeiro da Conceição ◽  
Priscila Nóbrega-Sousa ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Obstacle Avoidance ◽  
Primary Motor Cortex ◽  
Cortical Activity ◽  
Postural Instability ◽  
Cortical Activation ◽  
Motor Area ◽  
Gait Disorder ◽  
Beta Power

Abstract Parkinson’s disease (PD) is often classified into tremor dominant (TD) and postural instability gait disorder (PIGD) subtypes. Degeneration of subcortical/cortical pathways is different between PD subtypes, which leads to differences in motor behavior. However, the influence of PD subtype on cortical activity during walking remains poorly understood. Therefore, we aimed to investigate the influence of PD motor subtypes on cortical activity during unobstructed walking and obstacle avoidance. Seventeen PIGD and 19 TD patients performed unobstructed walking and obstacle avoidance conditions. Brain activity was measured using a mobile functional near-infrared spectroscopy–electroencephalography (EEG) systems, and gait parameters were analyzed using an electronic carpet. Concentrations of oxygenated hemoglobin (HbO2) of the prefrontal cortex (PFC) and EEG absolute power from alpha, beta, and gamma bands in FCz, Cz, CPz, and Oz channels were calculated. These EEG channels correspond to supplementary motor area, primary motor cortex, posterior parietal cortex, and visual cortex, respectively. Postural instability gait disorder patients presented higher PFC activity than TD patients, regardless of the walking condition. Tremor dominant patients presented reduced beta power in the Cz channel during obstacle avoidance compared to unobstructed walking. Both TD and PIGD patients decreased alpha and beta power in the FCz and CPz channels. In conclusion, PIGD patients need to recruit additional cognitive resources from the PFC for walking. Both TD and PIGD patients presented changes in the activation of brain areas related to motor/sensorimotor areas in order to maintain balance control during obstacle avoidance, being that TD patients presented further changes in the motor area (Cz channel) to avoid obstacles.

Utilising functional MRI (fMRI) to explore the freezing phenomenon in Parkinson’s disease

2011 ◽  
Vol 18 (6) ◽  
pp. 807-810 ◽  
Author(s):  
James M. Shine ◽  
Philip B. Ward ◽  
Sharon L. Naismith ◽  
Mark Pearson ◽  
Simon J.G. Lewis
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Mri

Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease

2004 ◽  
Vol 14 (4) ◽  
pp. 686-690 ◽  
Author(s):  
Bettina Sorger ◽  
Ralf Girnus ◽  
Oliver Schulte ◽  
Barbara Krug ◽  
Klaus Lackner ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Functional Mri ◽  
Brain Stimulation ◽  
New Approach ◽  
Deep Brain

Improved Motor Function And Cortical Activation In Parkinson'S Disease Patients Following Acute Forced-exercise

2009 ◽  
Vol 41 ◽  
pp. 148 ◽  
Author(s):  
Angela L. Ridgel ◽  
Jerrold L. Vitek ◽  
Michael D. Phillips ◽  
Mark J. Lowe ◽  
Mark Hutson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Function ◽  
Cortical Activation

scholarly journals Progressive Resistance Exercise and Parkinson's Disease: A Review of Potential Mechanisms

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Fabian J. David ◽  
Miriam R. Rafferty ◽  
Julie A. Robichaud ◽  
Janey Prodoehl ◽  
Wendy M. Kohrt ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Resistance Exercise ◽  
Cortical Activation ◽  
Future Research ◽  
Healthy Individuals ◽  
Beneficial Effects ◽  
Positive Effects ◽  
Progressive Resistance Exercise ◽  
Progressive Resistance

This paper reviews the therapeutically beneficial effects of progressive resistance exercise (PRE) on Parkinson's disease (PD). First, this paper discusses the rationale for PRE in PD. Within the first section, the review discusses the central mechanisms that underlie bradykinesia and muscle weakness, highlights findings related to the central changes that accompany PRE in healthy individuals, and extends these findings to individuals with PD. It then illustrates the hypothesized positive effects of PRE on nigro-striatal-thalamo-cortical activation and connectivity. Second, it reviews recent findings of the use of PRE in individuals with PD. Finally, knowledge gaps of using PRE on individuals with PD are discussed along with suggestions for future research.

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