Comparative genomic analysis of dwarf Vibrio myoviruses defines a conserved gene cluster for successful phage infection

2022 ◽  
Author(s):  
Dimitrios Skliros ◽  
Efthymios Karpouzis ◽  
Chrysanthi Kalloniati ◽  
Pantelis Katharios ◽  
Emmanouil Flemetakis
Keyword(s):  
Gene Cluster ◽  
Genomic Analysis ◽  
Comparative Genomic Analysis ◽  
Phage Infection ◽  
Comparative Genomic ◽  
Conserved Gene

scholarly journals Comparative Genomic Analysis ofLactococcus garvieaeStrains Isolated from Different Sources Reveals Candidate Virulence Genes

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Eiji Miyauchi ◽  
Hidehiro Toh ◽  
Akiyo Nakano ◽  
Soichi Tanabe ◽  
Hidetoshi Morita
Keyword(s):  
Gene Cluster ◽  
Host Specificity ◽  
Virulence Genes ◽  
Genomic Analysis ◽  
Comparative Genomic Analysis ◽  
Pathogenic Strain ◽  
Comparative Genomic ◽  
Genome Sequences ◽  
Lactococcus Garvieae ◽  
Different Sources

Lactococcus garvieaeis a major pathogen for fish. Two complete (ATCC 49156 and Lg2) and three draft (UNIUD074, 8831, and 21881) genome sequences ofL. garvieaehave recently been released. We here present the results of a comparative genomic analysis of these fish and human isolates ofL. garvieae. The pangenome comprised 1,542 core and 1,378 dispensable genes. The sequencedL. garvieaestrains shared most of the possible virulence genes, but the capsule gene cluster was found only in fish-pathogenic strain Lg2. The absence of the capsule gene cluster in other nonpathogenic strains isolated from mastitis and vegetable was also confirmed by PCR. The fish and human isolates ofL. garvieaecontained the specific two and four adhesin genes, respectively, indicating that these adhesion proteins may be involved in the host specificity differences ofL. garvieae. The discoveries revealed by the pangenomic analysis may provide significant insights into the biology ofL. garvieae.

scholarly journals Comparative Genomic Analysis of the Interferon/Interleukin-10 Receptor Gene Cluster

1999 ◽  
Vol 9 (3) ◽  
pp. 242-250
Author(s):  
Jérôme Reboul ◽  
Katheleen Gardiner ◽  
Danièle Monneron ◽  
Gilles Uzé ◽  
Georges Lutfalla
Keyword(s):  
Gene Cluster ◽  
Large Scale ◽  
Receptor Gene ◽  
Genomic Analysis ◽  
Interleukin 10 ◽  
Comparative Genomic Analysis ◽  
Chromosome 21 ◽  
Comparative Genomic ◽  
Interferon Α ◽  
Link Type

Interferons and interleukin-10 are involved in key aspects of the host defence mechanisms. Human chromosome 21 harbors the interferon/interleukin-10 receptor gene cluster linked to theGART gene. This cluster includes both components of the interferon α/β-receptor (IFNAR1 and IFNAR2) and the second components of the interferon γ-receptor (IFNGR2) and of the IL-10 receptor (IL10R2). We report here the complete gene content of this GART–cytokine receptor gene cluster and the use of comparative genomic analysis to identify chicken IFNAR1, IFNAR2, andIL10R2. We show that the large-scale structure of this locus is conserved in human and chicken but not in the pufferfish Fugu rubripes. This establishes that the receptor components of these host defense mechanisms were fixed in an ancestor of the amniotes. The extraordinary diversification of the interferon ligand family during the evolution of birds and mammals has therefore occured in the context of a fixed receptor structure.[The sequence data described in this paper have been submitted to GenBank under accession nos.AF039904, AF039905, AF039906, AF039907, AF045606, AF082664, AF082665,AF082666, AF082667, and AF083221.]

scholarly journals Comparative genomic analysis demonstrates that true reinfection following SARS-CoV-2 infection is possible

2021 ◽  
pp. 100015
Author(s):  
Eamon O. Murchu ◽  
Sinead O'Neill ◽  
Paula Byrne ◽  
Cillian De Gascun ◽  
Michelle O'Neill ◽  
...  
Keyword(s):  
Genomic Analysis ◽  
Comparative Genomic Analysis ◽  
Comparative Genomic

Enhancing the production of amphotericin B by Strepyomyces nodosus in a 50-ton bioreactor based on comparative genomic analysis

3 Biotech ◽  
2021 ◽  
Vol 11 (6) ◽  
Author(s):  
Kai Huang ◽  
Bo Zhang ◽  
Yu Chen ◽  
Zhe-Ming Wu ◽  
Zhi-Qiang Liu ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Genomic Analysis ◽  
Comparative Genomic Analysis ◽  
Comparative Genomic
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