Analysis of intermolecular disulfide bonds and free sulfhydryl groups in hepatitis B surface antigen particles

We report on the binding of biotin, and hence of biotinylated antibodies and lectins, to ground glass hepatocytes and liver cell membranes in chronic hepatitis B viral infection. This binding is of low affinity, and was proved to be directed at the hepatitis B surface antigen, presumably at its disulfide bonds. To avoid false-positive results, this affinity should be considered in the interpretation of immunohistochemical stainings of hepatitis B virus-infected liver tissue with biotinylated reagents.

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Reporting hepatitis-B surface antigen-positive pregnant women

PsycEXTRA Dataset ◽

10.1037/e411652008-008 ◽

2005 ◽

Keyword(s):

Hepatitis B ◽

Pregnant Women ◽

Surface Antigen ◽

Hepatitis B Surface Antigen

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Unexpected increase of Hepatitis B Surface Antigen (HBsAg) levels during treatment with nucleos(t)ide analogous 12–24 months before virological breakthrough and resistance

Zeitschrift für Gastroenterologie ◽

10.1055/s-0031-1295950 ◽

2012 ◽

Vol 50 (01) ◽

Author(s):

S Wiegand ◽

J Jaroszewicz ◽

B Zacher ◽

K Wursthorn ◽

K Deterding ◽

...

Keyword(s):

Hepatitis B ◽

Surface Antigen ◽

Hepatitis B Surface Antigen ◽

Virological Breakthrough

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IL10 Promotorpolymorphismen beeinflussen die Hepatitis B Surface Antigen und die Hepatitis A spezifische Immunantwort

Zeitschrift für Gastroenterologie ◽

10.1055/s-0035-1555166 ◽

2015 ◽

Vol 41 (08) ◽

Author(s):

E Reuss ◽

N Evers ◽

N Dietrich ◽

J Vollmar ◽

PM Schneider ◽

...

Keyword(s):

Hepatitis B ◽

Surface Antigen ◽

Hepatitis A ◽

Hepatitis B Surface Antigen

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Effects of Vancomycin on Platelets, Plasma Proteins and Hepatitis B Surface Antigen

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651448 ◽

1975 ◽

Vol 34 (01) ◽

pp. 083-093 ◽

Cited By ~ 2

Author(s):

Barry S Coller ◽

W. B Lundberg ◽

Harvey R Gralnick

Keyword(s):

Hepatitis B ◽

Factor Viii ◽

Surface Antigen ◽

Plasma Proteins ◽

Hepatitis B Surface Antigen ◽

Infusion Site ◽

Vancomycin Therapy ◽

Intravenous Injections ◽

Low Concentrations ◽

High Doses

SummaryThe antibiotic vancomycin shares many similarities with ristocetin, an agent noted for its effects on platelets and plasma fibrinogen. Vancomycin did not aggregate platelets as ristocetin, but platelets were incorporated into precipitates induced by vancomycin. Fibrinogen and factor VIII were precipitated from plasma at low concentrations of vancomycin. The precipitated fibrinogen remained clottable. Hepatitis B surface antigen was selectively precipitated from serum and could be recovered from the precipitate. Rabbits receiving bolus intravenous injections of high doses of vancomycin developed hypofibrinogenemia and thrombocytopenia within minutes and often went on to die. Studies with 125I-vancomycin revealed little stable binding of the antibiotic to platelets or fibrinogen. A relationship is suggested between the potent protein precipitating effects and phlebitis at the infusion site commonly associated with vancomycin therapy.

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