Vitamin D receptor gene polymorphisms and bone mass indices in post-menarchal Indian adolescent girls

2012 ◽  
Vol 31 (1) ◽  
pp. 108-115 ◽  
Author(s):  
Neha Sanwalka ◽  
Anuradha Khadilkar ◽  
Shashi Chiplonkar ◽  
Kavita Khatod ◽  
Nikhil Phadke ◽  
...  
2008 ◽  
Vol 138 (2) ◽  
pp. 277-281 ◽  
Author(s):  
Flávia F. Bezerra ◽  
Giselda M. K. Cabello ◽  
Laura M. C. Mendonça ◽  
Carmen M. Donangelo

Author(s):  
Surendar Aravindhan ◽  
Mohammed Fadhil Mohammed Almasoody ◽  
Nihad Abdallah Selman ◽  
Alekhina Natalia Andreevna ◽  
Sahithya Ravali ◽  
...  

2006 ◽  
Vol 175 (5) ◽  
pp. 1613-1623 ◽  
Author(s):  
Sonja I. Berndt ◽  
Jennifer L. Dodson ◽  
Wen-Yi Huang ◽  
Kristin K. Nicodemus

1970 ◽  
Vol 19 (4) ◽  
pp. 2812-2818
Author(s):  
Ayman S Al-Hazmi

Background: Type 2 diabetes mellitus (T2DM) is a global problem. Association of multiple genes in T2DM becomes a hot point recently. This study was aimed to evaluate association of vitamin D receptor gene polymorphisms with susceptibility to T2DM. Subjects and methods: One hundred T2DM Saudi male patients were included in this study and one hundred healthy Saudi men were used as control. For each individual, fasting blood glucose, cholesterol, HDL-C, LDL-C, HbA1c, insulin and 25-(OH) vitamin D were measured. In addition, Apal, BsmI and TaqI genotypes were performed for each subject. Data was analyzed by SPSS version 16, using Spearman's rho and ANOVA tests. Results: There was significant inverse correlation between 25-(OH) vitamin D level and T2DM (p<0.01). HbA1c was inversely correlated with 25-(OH) vitamin D level (P<0.05). Genotype study showed that tt of TaqI genotype was higher in T2DM group compared with control group (p<0.05). Moreover, tt genotype has higher HbA1c than both TT and Tt genotypes (p<0.05). Conclusion: An association was confirmed between TaqI genotypes and T2DM but there is no correlation between BsmI, ApaI and T2DM. In addition, HbA1c is positively correlated with tt genotype of TaqI.Keywords: Vitamin D receptor, diabetes type 2, polymorphism.


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