Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis

2000 ◽  
Vol 5 (6) ◽  
pp. 546-551 ◽  
Author(s):  
Jun Iwamoto ◽  
Tsuyoshi Takeda ◽  
Shoichi Ichimura



Maturitas ◽  
1999 ◽  
Vol 31 (2) ◽  
pp. 161-164 ◽  
Author(s):  
Ichiro Iwamoto ◽  
Shoichiro Kosha ◽  
Shin-ichi Noguchi ◽  
Masato Murakami ◽  
Toshinori Fujino ◽  
...  


2014 ◽  
Vol 7 ◽  
pp. CMED.S15086 ◽  
Author(s):  
Helisane Lima ◽  
Juliana Maia ◽  
Francisco Bandeira

Objective To evaluate the responses of C-terminal telopeptide (CTX) and serum osteocalcin after the first 4 months of treatment with strontium ranelate (SR) and demonstrate their association with long-term bone density changes. Subjects and Methods A sample of 13 postmenopausal women with osteoporosis was analyzed (mean age 65 ± 7.7 years), who were treated with SR for an average of 2.56 ± 0.86 years. All patients had undergone previous treatment with bisphosphonates for an average period of 4.88 ± 2.27 years. Serum CTX and osteocalcin levels were determined before and after four months of treatment with SR. Bone mineral density in the lumbar spine and femoral neck were obtained before and after treatment with SR. Results We observed an average increase of 53.7% in the CTX levels, and 30.7% in the osteocalcin levels. The increase in bone markers was associated with a mean 4.8% increase in lumbar spine bone mineral density (BMD) from 0.820 to 0.860 g/cm2 ( T-score from –2.67 to –1.92; P= 0.001), after 2.5 years of treatment with SR. Conclusion These data suggest an anabolic effect of SR on postmenopausal women who were previously treated with long-term bisphosphonates.



2008 ◽  
Vol 31 (6) ◽  
pp. 1191-1197 ◽  
Author(s):  
Hiroyuki SUMINO ◽  
Shuichi ICHIKAWA ◽  
Shu KASAMA ◽  
Takashi TAKAHASHI ◽  
Hironosuke SAKAMOTO ◽  
...  


Heart ◽  
2012 ◽  
Vol 98 (Suppl 2) ◽  
pp. E72.3-E72
Author(s):  
Zhao Yuan ◽  
Xing Yan ◽  
Liu Wen-ya ◽  
Yang Wen ◽  
Wang Hai-tao ◽  
...  


2011 ◽  
Vol 26 (2) ◽  
pp. 168
Author(s):  
Alfredo Ceballos ◽  
Gladys Castaño ◽  
Sarahí Mendoza ◽  
Juan González ◽  
Rosa Mas ◽  
...  


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