Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid

2021 ◽  
Author(s):  
Rafael Simões Gonçalves ◽  
Polliana Mendes Candia Scaffa ◽  
Mirela Sanae Shinohara ◽  
Paulo Roberto Marão de Andrade Carvalho ◽  
Marília Afonso Rabelo Buzalaf ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Gingival Crevicular Fluid ◽  
Cervical Lesions ◽  
Crevicular Fluid

The effect of photobiomodulation on total amount of substance P in gingival crevicular fluid: placebo-controlled randomized clinical trial

2018 ◽  
Vol 34 (3) ◽  
pp. 517-523 ◽  
Author(s):  
Ezgi Doğanay Yıldız ◽  
Hakan Arslan ◽  
Serhat Köseoğlu ◽  
Taner Arabacı ◽  
Dursun Anıl Yıldız ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Substance P ◽  
Randomized Clinical Trial ◽  
Gingival Crevicular Fluid ◽  
Amount Of Substance ◽  
Crevicular Fluid

scholarly journals Non-Surgical Periodontal Therapy with Adjunctive Amoxicillin/Metronidazole or Metronidazole When No Aggregatibacter actinomycetemcomitans Is Detected—A Randomized Clinical Trial

Antibiotics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 686
Author(s):  
Holger F. R. Jentsch ◽  
Martin Dietrich ◽  
Sigrun Eick
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Gingival Crevicular Fluid ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Periodontal Therapy ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Crevicular Fluid ◽  
Systemic Antibiotics ◽  
Attachment Level

Background: The aim was to compare two different systemic antibiotics regimens adjunctive to non-surgical periodontal therapy when Aggregatibacter actinomycetemcomitans was not detected in the subgingival biofilm. Methods: A total of 58 patients with periodontitis and with no A. actinomycetemcomitans in the subgingival biofilm were treated with full-mouth subgingival instrumentation and either metronidazole (MET; n = 29) or amoxicillin/metronidazole (AMX/MET; n = 29). Probing depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) were recorded at baseline, as well as after three and six months. Subgingival biofilm and gingival crevicular fluid were collected and analyzed for major periodontopathogens and biomarkers. Results: PD, CAL and BOP improved at 3 and 6 months (each p < 0.001 vs. baseline) with no difference between the groups. Sites with initial PD ≥ 6 mm also improved in both groups after 3 and 6 months (p < 0.001) with a higher reduction of PD in the AMX/MET group (p < 0.05). T. forsythia was lower in the AMX/MET group after 3 months (p < 0.05). MMP-8 and IL-1β were without significant changes and differences between the groups. Conclusion: When A. actinomycetemcomitans was not detected in the subgingival biofilm, the adjunctive systemic use of amoxicillin/metronidazole results in better clinical and microbiological outcomes of non-surgical periodontal therapy when the application of systemic antibiotics is scheduled.

scholarly journals Six month follow-up of two Bulk-fill composites in non-carious cervical lesions: Double blind randomized clinical trial.

2020 ◽  
Vol 8 (3) ◽  
pp. 210-219
Author(s):  
Patricio Vildósola ◽  
◽  
Jorge Nakouzi ◽  
Sara Rodriguez ◽  
Alexandra Reyes ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Cervical Lesions ◽  
Double Blind

Six-month Follow-up of the Effect of Nonvital Bleaching on IL-1β and RANK-L: A Randomized Clinical Trial

2019 ◽  
Vol 44 (6) ◽  
pp. 581-588 ◽  
Author(s):  
C Bersezio ◽  
J Estay ◽  
M Sáez ◽  
F Sánchez ◽  
R Vernal ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hydrogen Peroxide ◽  
Randomized Clinical Trial ◽  
Gingival Crevicular Fluid ◽  
Color Change ◽  
Double Blind ◽  
Time Points ◽  
Periodontal Tissues ◽  
Significant Difference ◽  
Spearman Test

SUMMARY Objectives: It has been reported that bleaching generates an increase in the activity of osteoclasts in vitro. We quantified the RANK-L and IL-1β biomarkers in a double-blind, randomized clinical trial evaluating the in vivo effect of hydrogen peroxide (35%) and peroxide carbamide (37%) six months after whitening. Methods and Materials: Fifty volunteers participated, each with color change in a nonvital tooth. Fifty teeth were randomly divided into two groups (n=25), and the teeth were bleached using either 35% hydrogen peroxide (G1) or 37% carbamide peroxide (G2). Intracoronal bleaching was carried out by a technical “walking bleach” over four sessions. Gingival crevicular fluid samples were collected and used to quantify the IL-1β and RANK-L secreted levels. Samples of six periodontal sites (three vestibular and three palatal) were collected for up to six months (at the beginning of the study [baseline] and at one week, one month, and six months posttreatment). The color change was visually monitored using the Vita Bleached Guide (ΔSGU). Results: Comparing each time to baseline assessment, a significant increase in the levels of IL-1β and RANK-L across time points was detected (p&lt;0.05). The color change was 4 in G1 and G2, and a statistically significant difference (p&lt;0.05) was found at the month time point between the groups. Using the Spearman test, a strong correlation (&gt;0.8) between the IL-1β and RANK-L levels in both groups at all time points was detected. Conclusions: Nonvital bleaching using a technical walking bleach induces an increase in the IL-1β and RANKL production in periodontal tissues, which persists for six months after treatment. Both biomarkers were highly correlated in both groups and at all time points.

scholarly journals Six-month Follow-up of Cervical Composite Restorations Placed With a New Universal Adhesive System: A Randomized Clinical Trial

2016 ◽  
Vol 41 (5) ◽  
pp. 465-480 ◽  
Author(s):  
LS Lopes ◽  
FS Calazans ◽  
R Hidalgo ◽  
LL Buitrago ◽  
F Gutierrez ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Retention Rate ◽  
Evaluation Criteria ◽  
Cervical Lesions ◽  
Universal Adhesive ◽  
Double Blind ◽  
Etch And Rinse ◽  
Significant Difference ◽  
Self Etch

SUMMARY Purpose: The objective of this double-blind, randomized clinical trial was to evaluate the six-month clinical performance of a new universal adhesive (Xeno Select, Dentsply) in noncarious cervical lesions (NCCLs) using two evaluation criteria: World Dental Federation (FDI) and the US Public Health Service (USPHS). Methods and Materials: A total of 124 restorations were randomly placed in 31 patients according to the following groups: ER-D = etch-and-rinse/dry dentin; ER-M = etch-and-rinse/moist dentin; SE-et = selective enamel etching; and SET = self-etch. The composite resin EVOLUX (Dentsply) was placed incrementally. The restorations were evaluated after one week (baseline) and at six months using the FDI and USPHS criteria. Statistical analyses were performed using appropriate tests (α=0.05). Results: Fifteen restorations were lost or fractured at six months (one for ER-D, three for ER-M, five for SE-et, and six for SET) (p&gt;0.05 at six-month recall). When ER (ER-D and ER-M) was compared with SE (SE-et and SET) there was a significant difference in the retention rate after six months (p=0.001). Marginal staining and postoperative sensitivity to air were only observed in three (one for ER-M and two for SET) and two restorations (two for ER-D) in both evaluation criteria (p&gt;0.05), respectively. Forty-seven restorations were considered to have minor discrepancies in marginal adaptation at the six-month recall using the FDI criteria (13 for ER-D, 10 for ER-M, 11 for SE-et, and 13 for SET; p&gt;0.05 between groups). However, for all groups, a significant difference was detected when baseline and six-month data were compared (p&lt;0.05). Conclusions: The six-month clinical behavior of Xeno Select Universal Adhesive depends on the bonding strategy used. The universal adhesive did not fulfill the American Dental Association criteria for full approval when used in the self-etch mode.

Two-year clinical evaluation of a proanthocyanidins-based primer in non-carious cervical lesions: A double-blind randomized clinical trial

2020 ◽  
Vol 96 ◽  
pp. 103325 ◽  
Author(s):  
Lidiane Costa de Souza ◽  
Nara Sousa Rodrigues ◽  
Diana Araújo Cunha ◽  
Victor Pinheiro Feitosa ◽  
Sérgio Lima Santiago ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Clinical Evaluation ◽  
Cervical Lesions ◽  
Double Blind

Four-year randomized clinical trial of oxalic acid pretreatment in restorations of non-carious cervical lesions

2015 ◽  
Vol 20 (2) ◽  
pp. 199-205 ◽  
Author(s):  
Nadine Luísa Guimarães Albuquerque ◽  
André Mattos Brito de Souza ◽  
Maria Denise Rodrigues de Moraes ◽  
Juliano Sartori Mendonça ◽  
Lidiany Karla Azevedo Rodrigues ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Oxalic Acid ◽  
Randomized Clinical Trial ◽  
Cervical Lesions ◽  
Acid Pretreatment
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