The effect of photobiomodulation on total amount of substance P in gingival crevicular fluid: placebo-controlled randomized clinical trial

2018 ◽  
Vol 34 (3) ◽  
pp. 517-523 ◽  
Author(s):  
Ezgi Doğanay Yıldız ◽  
Hakan Arslan ◽  
Serhat Köseoğlu ◽  
Taner Arabacı ◽  
Dursun Anıl Yıldız ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Substance P ◽  
Randomized Clinical Trial ◽  
Gingival Crevicular Fluid ◽  
Amount Of Substance ◽  
Crevicular Fluid

scholarly journals Non-Surgical Periodontal Therapy with Adjunctive Amoxicillin/Metronidazole or Metronidazole When No Aggregatibacter actinomycetemcomitans Is Detected—A Randomized Clinical Trial

Antibiotics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 686
Author(s):  
Holger F. R. Jentsch ◽  
Martin Dietrich ◽  
Sigrun Eick
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Gingival Crevicular Fluid ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Periodontal Therapy ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Crevicular Fluid ◽  
Systemic Antibiotics ◽  
Attachment Level

Background: The aim was to compare two different systemic antibiotics regimens adjunctive to non-surgical periodontal therapy when Aggregatibacter actinomycetemcomitans was not detected in the subgingival biofilm. Methods: A total of 58 patients with periodontitis and with no A. actinomycetemcomitans in the subgingival biofilm were treated with full-mouth subgingival instrumentation and either metronidazole (MET; n = 29) or amoxicillin/metronidazole (AMX/MET; n = 29). Probing depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) were recorded at baseline, as well as after three and six months. Subgingival biofilm and gingival crevicular fluid were collected and analyzed for major periodontopathogens and biomarkers. Results: PD, CAL and BOP improved at 3 and 6 months (each p < 0.001 vs. baseline) with no difference between the groups. Sites with initial PD ≥ 6 mm also improved in both groups after 3 and 6 months (p < 0.001) with a higher reduction of PD in the AMX/MET group (p < 0.05). T. forsythia was lower in the AMX/MET group after 3 months (p < 0.05). MMP-8 and IL-1β were without significant changes and differences between the groups. Conclusion: When A. actinomycetemcomitans was not detected in the subgingival biofilm, the adjunctive systemic use of amoxicillin/metronidazole results in better clinical and microbiological outcomes of non-surgical periodontal therapy when the application of systemic antibiotics is scheduled.

Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid

2021 ◽  
Author(s):  
Rafael Simões Gonçalves ◽  
Polliana Mendes Candia Scaffa ◽  
Mirela Sanae Shinohara ◽  
Paulo Roberto Marão de Andrade Carvalho ◽  
Marília Afonso Rabelo Buzalaf ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Gingival Crevicular Fluid ◽  
Cervical Lesions ◽  
Crevicular Fluid

Six-month Follow-up of the Effect of Nonvital Bleaching on IL-1β and RANK-L: A Randomized Clinical Trial

2019 ◽  
Vol 44 (6) ◽  
pp. 581-588 ◽  
Author(s):  
C Bersezio ◽  
J Estay ◽  
M Sáez ◽  
F Sánchez ◽  
R Vernal ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hydrogen Peroxide ◽  
Randomized Clinical Trial ◽  
Gingival Crevicular Fluid ◽  
Color Change ◽  
Double Blind ◽  
Time Points ◽  
Periodontal Tissues ◽  
Significant Difference ◽  
Spearman Test

SUMMARY Objectives: It has been reported that bleaching generates an increase in the activity of osteoclasts in vitro. We quantified the RANK-L and IL-1β biomarkers in a double-blind, randomized clinical trial evaluating the in vivo effect of hydrogen peroxide (35%) and peroxide carbamide (37%) six months after whitening. Methods and Materials: Fifty volunteers participated, each with color change in a nonvital tooth. Fifty teeth were randomly divided into two groups (n=25), and the teeth were bleached using either 35% hydrogen peroxide (G1) or 37% carbamide peroxide (G2). Intracoronal bleaching was carried out by a technical “walking bleach” over four sessions. Gingival crevicular fluid samples were collected and used to quantify the IL-1β and RANK-L secreted levels. Samples of six periodontal sites (three vestibular and three palatal) were collected for up to six months (at the beginning of the study [baseline] and at one week, one month, and six months posttreatment). The color change was visually monitored using the Vita Bleached Guide (ΔSGU). Results: Comparing each time to baseline assessment, a significant increase in the levels of IL-1β and RANK-L across time points was detected (p&lt;0.05). The color change was 4 in G1 and G2, and a statistically significant difference (p&lt;0.05) was found at the month time point between the groups. Using the Spearman test, a strong correlation (&gt;0.8) between the IL-1β and RANK-L levels in both groups at all time points was detected. Conclusions: Nonvital bleaching using a technical walking bleach induces an increase in the IL-1β and RANKL production in periodontal tissues, which persists for six months after treatment. Both biomarkers were highly correlated in both groups and at all time points.

scholarly journals Comparative study of substance P and neurokinin A in gingival crevicular fluid of healthy and painful carious permanent teeth

2017 ◽  
Vol 14 (1) ◽  
pp. 57 ◽  
Author(s):  
Pegah Rahbar ◽  
Alireza Heidari ◽  
Mahdi Shahrabi ◽  
Mehrak Rokouei ◽  
Aliakbar Amirzargar
Keyword(s):  
Substance P ◽  
Comparative Study ◽  
Gingival Crevicular Fluid ◽  
Permanent Teeth ◽  
Neurokinin A ◽  
Crevicular Fluid
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