Collagen deposition correlates with loss of E-cadherin and increased p63 expression in dysplastic conditions of oral submucous fibrosis

2021 ◽  
Author(s):  
Sourangshu Chakraborti ◽  
Ranjan Rashmi Paul ◽  
Mousumi Pal ◽  
Jyotirmoy Chatterjee ◽  
Raunak Kumar Das
Keyword(s):  
Oral Submucous Fibrosis ◽  
Collagen Deposition ◽  
Submucous Fibrosis ◽  
E Cadherin

Assessment of malignant potential of oral submucous fibrosis through evaluation of p63, E-cadherin and CD105 expression

2010 ◽  
Vol 63 (10) ◽  
pp. 894-899 ◽  
Author(s):  
R. K. Das ◽  
M. Pal ◽  
A. Barui ◽  
R. R. Paul ◽  
C. Chakraborty ◽  
...  
Keyword(s):  
Oral Submucous Fibrosis ◽  
Malignant Potential ◽  
Submucous Fibrosis ◽  
E Cadherin

Epithelial Distribution of E-Cadherin, p63, and Mitotic Figures in ApoTome Images to Determine the Oncogenic Potentiality of Oral Submucous Fibrosis

2020 ◽  
Vol 26 (6) ◽  
pp. 1198-1210
Author(s):  
Reetoja Nag ◽  
Ranjan Rashmi Paul ◽  
Mousumi Pal ◽  
Jyotirmoy Chatterjee ◽  
Raunak Kumar Das
Keyword(s):  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis ◽  
Mitotic Figures ◽  
E Cadherin

Abstract

Correlation of epigenetic change and identification of risk factors for oral submucous fibrosis

2012 ◽  
Vol 27 (4) ◽  
pp. 314-321 ◽  
Author(s):  
Chunjiao Xu ◽  
Jing Zhao ◽  
Wings T.Y. Loo ◽  
Liang Hao ◽  
Min Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Oral Cancer ◽  
Chronic Inflammation ◽  
Healthy Subjects ◽  
Oral Submucous Fibrosis ◽  
Epigenetic Change ◽  
Submucous Fibrosis ◽  
Cox 2 ◽  
E Cadherin

Background DNA methylation of certain genes is an epigenetic change that is essential for tumorigenesis. Oral submucous fibrosis (OSF) is a precancerous condition of oral mucosa with inflammation and progressive fibrosis of the lamina propria and deeper connective tissue. The hypermethylation of E-cadherin and cyclooxygenase 2 (COX-2) in chronic inflammation may demonstrate a mild lesion/mutation at epigenetic levels. This study compares the hypermethylation status of E-cadherin and COX-2 genes in patients with oral cancer and patients with OSF and also aims to identify risk factors for the development of OSF. Methods DNA was extracted from blood samples of 50 healthy subjects, 50 patients with OSF and 60 patients with oral cancer. Methylation-specific polymerase chain reaction for E-cadherin and COX-2 was performed on these samples and the products were analyzed on 2% agarose gel. Surveys about oral health habits and clinical periodontal examinations in patients with OSF and healthy subjects were also conducted by well-trained dentists, and logistic regression was performed to identify risk factors for OSF. Results Hypermethylation of E-cadherin and COX-2 was observed in 36% and 22% of oral cancer samples, respectively. In patients with OSF, the rates were 52% and 30%, and in healthy controls the rates were 4% and 6%. Hypermethylation was shown to be correlated between the 3 groups with statistical significance (p<0.01). Methylation of CpG islands in E-cadherin and COX-2 occurred more frequently in patients with OSF than in the control group, but less frequently than in patients with oral cancer. In the logistic regression analysis, smoking, brushing more than twice daily, periodontal probing depth and plaque index were identified as 4 major risk factors for OSF. Conclusions These data confirm that E-cadherin and COX-2 expressions are related to OSF. The epigenetic changes presented in patients with chronic inflammation might demonstrate an irreversible destruction in the tissues or organs similar to the effects of cancer. Chronic OSF was significantly associated with hypermethylation, a cancer risk factor.

Correlated analysis of semi-quantitative immunohistochemical features of E-cadherin, VEGF and CD105 in assessing malignant potentiality of oral submucous fibrosis

2014 ◽  
Vol 210 (12) ◽  
pp. 1054-1063 ◽  
Author(s):  
Anji Anura ◽  
Raunak Kumar Das ◽  
Mousumi Pal ◽  
Ranjan Rashmi Paul ◽  
Ajoy Kumar Ray ◽  
...  
Keyword(s):  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis ◽  
E Cadherin

scholarly journals Comparative Study of Intralesional Dexamethasone Plus Hyaluronidase & Oral Colchicine in Patients with Oral Submucous Fibrosis

2018 ◽  
Vol 14 (2) ◽  
pp. 60-65
Author(s):  
Ganesh Prasad Neupane ◽  
Maya Rai ◽  
R. S. Rathore ◽  
V. K. Bhargava ◽  
A. K. Mahat ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Oral Mucosa ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Study Groups ◽  
T Test ◽  
Significant Difference ◽  
Intralesional Injections ◽  
Submucous Fibrosis ◽  
Larger Sample

Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition of the oral mucosa. It is characterized by excessive production of collagen leading to inelasticity of the oral mucosa and atrophic changes of the epithelium.Aim and objective: To evaluate the efficacy of oral Colchicine in comparison to intralesional injections of Dexamethasone plus Hyaluronidase in the management of OSMF patients.Materials and Methods: Fourty patients with OSMF were randomly divided equally into two groups. 20 patients in Dexamethasone group received biweekly intralesional injections of Dexamethasone (4mg/ml) plus Hyaluronidase 1500 IU in buccal mucosa for a period of 12 weeks. Other 20 patients in Colchicine group received oral Colchicine 0.5 mg tablets twice daily for 12 weeks. Parameters taken in the study were burning sensation, and mouth opening. Descriptive statistics, paired t test and unpaired t test were used for statistical analysis.Results and Conclusions: The pre- and post-treatment differences were found to be statistically significant for both the groups (p<0.001) and for both the treatment outcomes. When the average difference of the treatment outcomes was compared between the two study groups, statistically highly significant difference was noted (p <0.001) only in mouth opening but not in burning sensation.These encouraging results should prompt further clinical trials with Colchicine on a larger sample size to broaden the therapeutic usefulness of the drug in the management of OSMF. JNGMC,  Vol. 14 No. 2 December 2016, Page: 60-65

Localized peripheral autonomous neuropathy and dysfunctional myoepithelial cells: A novel hypothesis for xerostomia in oral submucous fibrosis

2020 ◽  
Vol 144 ◽  
pp. 109998
Author(s):  
Gargi S. Sarode ◽  
Sachin C. Sarode ◽  
Amol Gadbail ◽  
Shailesh Gondivkar ◽  
Shankargouda Patil
Keyword(s):  
Oral Submucous Fibrosis ◽  
Myoepithelial Cells ◽  
Submucous Fibrosis

Development and Validation of a Questionnaire to Evaluate Association of Tobacco Abuse With Oral Submucous Fibrosis

2011 ◽  
Vol 27 (2) ◽  
pp. NP132-NP142 ◽  
Author(s):  
Divya Mehrotra ◽  
Girdhar Gopal Agarwal ◽  
Sumit Kumar ◽  
Anand Shukla ◽  
Akash Asthana
Keyword(s):  
Oral Submucous Fibrosis ◽  
Tobacco Abuse ◽  
Submucous Fibrosis ◽  
Development And Validation
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