scholarly journals Her4-positive population in the tectum opticum is proliferating neural precursors in the adult zebrafish brain

2012 ◽  
Vol 33 (6) ◽  
pp. 627-632 ◽  
Author(s):  
Seung-Hyun Jung ◽  
Hyung-Seok Kim ◽  
Jae-Ho Ryu ◽  
Jung-Woo Gwak ◽  
Young-Ki Bae ◽  
...  
Keyword(s):  
Adult Zebrafish ◽  
Tectum Opticum ◽  
Neural Precursors ◽  
Zebrafish Brain ◽  
Positive Population

scholarly journals Critical Effects on Akt Signaling in Adult Zebrafish Brain Following Alterations in Light Exposure

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 637
Author(s):  
Nicholas S. Moore ◽  
Robert A. Mans ◽  
Mackenzee K. McCauley ◽  
Colton S. Allgood ◽  
Keri A. Barksdale
Keyword(s):  
Optic Tectum ◽  
Visual Processing ◽  
Environmental Enrichment ◽  
Glycogen Synthase ◽  
Light Exposure ◽  
Hsp70 Expression ◽  
Light Cycle ◽  
Adult Zebrafish ◽  
Sleep State ◽  
Zebrafish Brain

Evidence from human and animal studies indicate that disrupted light cycles leads to alterations of the sleep state, poor cognition, and the risk of developing neuroinflammatory and generalized health disorders. Zebrafish exhibit a diurnal circadian rhythm and are an increasingly popular model in studies of neurophysiology and neuropathophysiology. Here, we investigate the effect of alterations in light cycle on the adult zebrafish brain: we measured the effect of altered, unpredictable light exposure in adult zebrafish telencephalon, homologous to mammalian hippocampus, and the optic tectum, a significant visual processing center with extensive telencephalon connections. The expression of heat shock protein-70 (HSP70), an important cell stress mediator, was significantly decreased in optic tectum of adult zebrafish brain following four days of altered light exposure. Further, pSer473-Akt (protein kinase B) was significantly reduced in telencephalon following light cycle alteration, and pSer9-GSK3β (glycogen synthase kinase-3β) was significantly reduced in both the telencephalon and optic tectum of light-altered fish. Animals exposed to five minutes of environmental enrichment showed significant increase in pSer473Akt, which was significantly attenuated by four days of altered light exposure. These data show for the first time that unpredictable light exposure alters HSP70 expression and dysregulates Akt-GSK3β signaling in the adult zebrafish brain.

scholarly journals Induction of Oxidative Stress and Apoptosis in the Injured Brain: Potential Relevance to Brain Regeneration in Zebrafish.

2021 ◽  
Author(s):  
Surendra Kumar Anand ◽  
Manas Ranjan Sahu ◽  
Amal Chandra Mondal
Keyword(s):  
Oxidative Stress ◽  
Mrna Levels ◽  
Adult Zebrafish ◽  
Zebrafish Model ◽  
Stab Injury ◽  
Zebrafish Brain ◽  
Protein Levels ◽  
Injured Brain ◽  
Brain Regeneration ◽  
The Impact

Abstract In the recent years, zebrafish, owing to its tremendous adult neurogenic capacity, has emerged as a useful vertebrate model to study brain regeneration. Recent findings suggest a significant role of the BDNF/TrkB signaling as a mediator of brain regeneration following a stab injury in the adult zebrafish brain. Since BDNF has been implicated in a plethora of physiological processes, we hypothesized that these processes are affected in the injured zebrafish brain. In this small study, we examined the indicators of oxidative stress and of apoptosis using biochemical assays, RT-PCR and IHC to reflect upon the impact of stab injury on oxidative stress levels and apoptosis in the injured adult zebafish brain. Our results indicate induction of oxidative stress in the injured adult zebrafish brain. Also, apoptosis was induced in the injured brain as indicated by increased protein levels of cleaved caspase3 as well as enhanced mRNA levels of both pro-apoptotic and anti-apoptotic genes. This knowledge contributes to the overall understanding of adult neurogenesis in the zebrafish model and raises new questions pertaining to the compensatory physiological mechanisms in response to traumatic brain injury in the adult zebrafish brain.

scholarly journals gfap and nestin reporter lines reveal characteristics of neural progenitors in the adult zebrafish brain

2009 ◽  
Vol 238 (2) ◽  
pp. 475-486 ◽  
Author(s):  
Chen Sok Lam ◽  
Martin März ◽  
Uwe Strähle
Keyword(s):  
Neural Progenitors ◽  
Adult Zebrafish ◽  
Zebrafish Brain

scholarly journals Modeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain

10.3791/56014 ◽  
2017 ◽  
Author(s):  
Prabesh Bhattarai ◽  
Alvin Kuriakose Thomas ◽  
Mehmet Ilyas Cosacak ◽  
Christos Papadimitriou ◽  
Violeta Mashkaryan ◽  
...  
Keyword(s):  
Adult Zebrafish ◽  
Zebrafish Brain

scholarly journals PTZ-induced seizures inhibit adenosine deamination in adult zebrafish brain membranes

2011 ◽  
Vol 86 (5-6) ◽  
pp. 385-389 ◽  
Author(s):  
Anna Maria Siebel ◽  
Angelo Luis Piato ◽  
Katiucia Marques Capiotti ◽  
Kelly Juliana Seibt ◽  
Maurício Reis Bogo ◽  
...  
Keyword(s):  
Adult Zebrafish ◽  
Zebrafish Brain ◽  
Brain Membranes ◽  
Adenosine Deamination
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