Bone turnover markers, anterior pituitary and gonadal hormones, and bone mass evaluation using quantitative computed tomography in ankylosing spondylitis

2004 ◽  
Vol 24 (4) ◽  
pp. 346-351 ◽  
Author(s):  
Abdellah El Maghraoui ◽  
Saida Tellal ◽  
Souad Chaouir ◽  
Khalil Lebbar ◽  
Ahmed Bezza ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Ankylosing Spondylitis ◽  
Bone Mass ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Anterior Pituitary ◽  
Quantitative Computed Tomography ◽  
Gonadal Hormones ◽  
Turnover Markers

Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys

Bone ◽  
2011 ◽  
Vol 49 (2) ◽  
pp. 162-173 ◽  
Author(s):  
Michael S. Ominsky ◽  
Brian Stouch ◽  
Joseph Schroeder ◽  
Ian Pyrah ◽  
Marina Stolina ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Cortical Bone ◽  
Bone Turnover Markers ◽  
Mass Density ◽  
Bone Mass Density ◽  
Cynomolgus Monkeys ◽  
Turnover Markers ◽  
Cortical Bone Mass

Sex Steroids, Bone Mass and Bone Turnover Markers in Asian Indians

2014 ◽  
Vol 17 (3) ◽  
pp. 413
Author(s):  
M.P. Desai ◽  
K. Venkat ◽  
K. V. Bhanu Prakash ◽  
M. Khatkhatay
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Sex Steroids ◽  
Bone Turnover Markers ◽  
Asian Indians ◽  
Turnover Markers

Relationship Among VDR (BsmI and FokI), COLIA1, and CTR Polymorphisms with Bone Mass, Bone Turnover Markers, and Sex Hormones in Men

2002 ◽  
Vol 70 (6) ◽  
pp. 457-462 ◽  
Author(s):  
V. Braga ◽  
A. Sangalli ◽  
G. Malerba ◽  
M. Mottes ◽  
S. Mirandola ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Sex Hormones ◽  
Bone Turnover Markers ◽  
Turnover Markers

Low Bone Mass in Thalassemia: The Thalassemia Clinical Research Network (TCRN) Experience.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3613-3613
Author(s):  
Maria G. Vogiatzi ◽  
Joseph Lane ◽  
Martin Fleisher ◽  
Eric A. Macklin ◽  
Ellen B. Fung ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Bone Disease ◽  
Bone Turnover Markers ◽  
Research Network ◽  
Dietary Calcium Intake ◽  
Low Bone Mass ◽  
Mineral Density ◽  
T Score ◽  
Turnover Markers

Abstract Low bone mass is emerging as a frequent and debilitating morbidity in Thalassemia (thal). The TCRN conducted a cross-sectional observational study to determine the prevalence and factors contributing to bone disease among North American thal patients (pts). Spinal (L1-L4) Bone Mineral Density (BMD) Z- and T-score measurements by DXA (Hologic 4500 and Delphi models) were read centrally. Each subject’s weight, height, hematologic, endocrine and genetic parameters, iron chelation and transfusion regimens, dietary calcium intake, history of fractures and bone pain, self-reported physical activity and bone turnover markers were assessed. BMD was measured in 302 pts: 207 Thal Major (TM), 37 Thal Intermedia (TI), 35 Beta E, 7 Hemoglobin H disease (HbH), 2 homozygous alpha (α) and 14 HbH/Constant Spring (HbH/CS). Among all diagnostic groups, the prevalence of low bone mass (LBM; Z/T <-2), reduced bone mass (RBM; Z/T -2 to -1) and normal bone mass (NBM; Z/T >-1) was 52%, 27% and 21%, respectively. LBM prevalence was 55% in TM, 53% in TI, 51% in Beta E, 0% in HbH, 50% in α and 43% in HbH/CS. RBM prevalence was 26% in TM, 22% in TI, 31% in Beta E, 71% in HbH, 50% in α and 29% in HbH/CS. Pt groups aged: 6–11 yrs, 11–20 yrs, 20+ yrs had Z/T-scores mean±SD[n] were: −1.32±0.82[51], −1.73±1.08[77] and −2.43±1.14[174], respectively. Z/T-scores were significantly lower among older pts (p<.001) and significantly higher among heavier pts after controlling for Tanner stage. Mean age-adjusted Z/T-scores of thal diagnostic groups and their slopes vs. age did not differ significantly although the samples of some groups were small. Among TM and TI pts, those with genotype β°/β° tended to have lower age- and weight-adjusted Z/T-scores (mean [95% CI]: −2.25 [−2.65 to −1.86], n=39). Less than 1% had hypoparathyroidism, 4% vit D deficiency, 8.5% diabetes mellitus, 8.5% hypothyroidism and 11.5% growth hormone deficiency (GHD). Only GHD was significantly correlated with decreased Z/T-scores after controlling for age and diagnosis. Urinary N-telopeptide (NTx) is elevated across all three age groups (median[IQR] mM BCE/mM creatinine: 664[456–930], 302[90–624], 69[34–124]), respectively. Preliminary analysis of bone turnover markers in a subset of subjects (n=114) suggests that NTx, urinary or serum was a significant independent predictor of spine Z/T-scores controlled for age and age-adjusted weight. There was no relationship between Z/T-score and serum osteocalcin. This large and comprehensive study of thal bone disease has demonstrated that decreased bone mass occurs with high frequency, worsens with age, is affected by weight and GHD and is associated with elevated NTx, i.e. increased bone resorption. Future studies are needed to identify efficacious long-term therapies to improve thal bone disease.

scholarly journals Bone Turnover Markers Predict Bone Mass Development in Young Adult Men: A Five-Year Longitudinal Study

2015 ◽  
Vol 100 (4) ◽  
pp. 1460-1468 ◽  
Author(s):  
Anna Darelid ◽  
Martin Nilsson ◽  
Jenny M. Kindblom ◽  
Dan Mellström ◽  
Claes Ohlsson ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Young Adult ◽  
Bone Mass ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Adult Men ◽  
Mass Development ◽  
Turnover Markers
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