Association of FCRL4 polymorphisms on disease susceptibility and severity of ankylosing spondylitis in Chinese Han population

2012 ◽  
Vol 31 (10) ◽  
pp. 1449-1454 ◽  
Author(s):  
Zhen Zeng ◽  
Zhenhua Duan ◽  
Tianchen Zhang ◽  
Sheng Wang ◽  
Guixing Li ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Disease Susceptibility ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Association of KIF21B genetic polymorphisms with ankylosing spondylitis in a Chinese Han population of Shandong Province

2014 ◽  
Vol 34 (10) ◽  
pp. 1729-1736 ◽  
Author(s):  
Xinglin Yang ◽  
Ming Li ◽  
Liya Wang ◽  
Zhongdan Hu ◽  
Yuanchao Zhang ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Genetic Polymorphisms ◽  
Shandong Province ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

TIMP3 gene polymorphisms and relation to Ankylosing spondylitis susceptibility in Chinese Han population

2019 ◽  
Vol 46 (6) ◽  
pp. 472-478 ◽  
Author(s):  
Jiamin Wu ◽  
Zichao Xiong ◽  
Yao Sun ◽  
Jiangjiang Song ◽  
Fanglin Niu ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

The Association of LRP5 Gene Polymorphisms with Ankylosing Spondylitis in a Chinese Han Population

2011 ◽  
Vol 38 (12) ◽  
pp. 2616-2618 ◽  
Author(s):  
JIANMIN LIU ◽  
XIAOYAN ZHOU ◽  
ZHENXING SHAN ◽  
JIGUO YANG ◽  
QINGRUI YANG ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Multiple Testing ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Chinese Han Population ◽  
Nucleotide Polymorphisms ◽  
Multiple Testing Correction ◽  
Chinese Han ◽  
Han Population ◽  
Male Predominance

Objective.To clarify the association between polymorphisms of low-density lipoprotein receptor-related protein 5 (LRP5) with ankylosing spondylitis (AS) in a Chinese Han population.Methods.Sixteen patients with AS were recruited for preliminary screening through gene sequencing. Then 14 single-nucleotide polymorphisms (SNP) of LRP5 were followed up in 296 patients and 170 controls.Results.Sequencing the LRP5 showed 24 SNP including 3 novel SNP [LRP5SNP1 (c.-1596T > C), LRP5SNP2 (c.3764-30G > A), and LRP5SNP3 (c.4488+74G > A)]. Validation of SNP showed that the LRP5SNP3 were associated with AS after multiple testing correction (allele Pc = 0.0087, genotype Pc = 0.0316, haplotype AGA, Pc = 0.0051, OR = 2.54 and haplotype AGG, Pc = 0.048, OR = 0.63, respectively). The SNP rs686921 was associated with male predominance in both patients with AS (p = 0.032, OR 1.54) and controls (p = 0.014, OR 1.94).Conclusion.LRP5 may be involved in the pathogenesis of AS. Further study will be required to clarify the effect of LRP5 on the pathogenic mechanism of AS.

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