Therapeutic drug monitoring (TDM) as a tool in the switch from infliximab innovator to biosimilar in rheumatic patients: results of a 12-month observational prospective cohort study

2017 ◽  
Vol 36 (9) ◽  
pp. 2129-2134 ◽  
Author(s):  
E. M. H. Schmitz ◽  
S. Benoy - De Keuster ◽  
A. J. L. Meier ◽  
V. Scharnhorst ◽  
R. A. M. Traksel ◽  
...  
Keyword(s):  
Cohort Study ◽  
Therapeutic Drug Monitoring ◽  
Prospective Cohort Study ◽  
Drug Monitoring ◽  
Prospective Cohort ◽  
Therapeutic Drug ◽  
Observational Prospective Cohort Study ◽  
Rheumatic Patients

Early Use of Therapeutic Drug Monitoring to Individualize Infliximab Therapy in Paediatric IBD: A Multicentre Prospective Cohort Study

2017 ◽  
Vol 152 (5) ◽  
pp. S218-S219
Author(s):  
Eileen Crowley ◽  
Nicholas Carman ◽  
Valerie Arpino ◽  
Karen Frost ◽  
Amanda Ricciuto ◽  
...  
Keyword(s):  
Cohort Study ◽  
Therapeutic Drug Monitoring ◽  
Prospective Cohort Study ◽  
Drug Monitoring ◽  
Prospective Cohort ◽  
Infliximab Therapy ◽  
Therapeutic Drug ◽  
Early Use

scholarly journals Increased Mortality in Elderly Patients Admitted with Hyponatremia: A Prospective Cohort Study

2021 ◽  
Vol 10 (14) ◽  
pp. 3059
Author(s):  
Petros Ioannou ◽  
Symeon Panagiotakis ◽  
Emmanouela Tsagkaraki ◽  
Constantinos Tsioutis ◽  
Konstantinos Fragkiadakis ◽  
...  
Keyword(s):  
Cohort Study ◽  
Elderly Patients ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Total Mortality ◽  
University Hospital ◽  
Electrolyte Disorder ◽  
Admission Rates ◽  
Observational Prospective Cohort Study ◽  
Current Guidelines

Hyponatremia is the most common electrolyte disorder, commonly affecting older hospitalized individuals; however, the literature is not clear regarding its effect on mortality. The aim of this 2-year observational prospective cohort study was to evaluate the mortality and re-admission rates, the clinical and laboratory characteristics and the causes of hyponatremia in patients older than 65 years admitted with a corrected serum sodium of 130 mEq/L or less in an internal medicine ward of a tertiary Greek university hospital. During the observation period, 138 patients (mean age 80.5 years, 36.2% male) fulfilled the inclusion criteria and were prospectively followed for 1 year after admission. Symptoms of hyponatremia were present in 59.4% of patients. Hypovolemia was the main sole cause of hyponatremia, but in about one third of patients, hyponatremia was multifactorial. Only a low proportion of patients (12.3%) fulfilled the criteria of the syndrome of inappropriate antidiuresis (SIAD) at admission according to the current guidelines. The re-admission rates at 3- and 12-months following discharge was 34.2% and 51.8%, respectively. Mortality during hospitalization was 17.4% and was higher compared to non-hyponatremic admitted older patients, while the total mortality at 1 year after admission was 28.3%, indicating that hyponatremia at admission is a marker of significant mortality during and after hospitalization in elderly patients.

A(H1N1)v2009: A controlled observational prospective cohort study on vaccine safety in pregnancy

Vaccine ◽  
2012 ◽  
Vol 30 (30) ◽  
pp. 4445-4452 ◽  
Author(s):  
Marc Oppermann ◽  
Juliane Fritzsche ◽  
Corinna Weber-Schoendorfer ◽  
Brigitte Keller-Stanislawski ◽  
Arthur Allignol ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Vaccine Safety ◽  
Observational Prospective Cohort Study ◽  
In Pregnancy
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