Indications and risk factors for hospitalization in patients with primary Sjögren syndrome: experience from a tertiary center in Turkey

Sjögren syndrome is a systemic autoimmune disease that principally affects women between the fourth and sixth decades of life who present with sicca symptomatology caused by dryness of the main mucosal surfaces. The clinical spectrum of Sjögren syndrome extends from dryness to systemic involvement. Since 1978, Sjögren syndrome has been closely associated with an enhanced risk of lymphoma, one of the most severe complications a patient may develop. Primary Sjögren syndrome patients have a 10–44-fold greater risk of lymphoma than healthy individuals, higher than that reported for systemic lupus erythematosus and rheumatoid arthritis. The close link between lymphoma and Sjögren syndrome is clearly exemplified by the very specific type of lymphoma arising in Sjögren syndrome patients, mainly low-grade B-cell lymphomas (predominantly a marginal zone histological type) with primary extranodal involvement of the major salivary glands (overwhelmingly parotid), with a primordial role of cryoglobulinemic-related markers (both clinical and immunological). The most recent studies support a higher number of risk factors detected in an individual leads to a higher lymphoma risk. A close follow-up of high-risk groups with longitudinal assessments of all known risk factors, including cryoglobulin-related markers and EULAR Sjögren's syndrome disease activity index measurement in particular, is mandatory.

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Risk factors for caries development in primary Sjogren syndrome

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2019.04.011 ◽

2019 ◽

Vol 128 (2) ◽

pp. 117-122 ◽

Cited By ~ 4

Author(s):

Nicola Berman ◽

Frederick Vivino ◽

Joshua Baker ◽

Jonathan Dunham ◽

Andres Pinto

Keyword(s):

Risk Factors ◽

Sjögren Syndrome ◽

Sjogren Syndrome ◽

Primary Sjögren Syndrome

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Faculty Opinions recommendation of Pulmonary arterial hypertension: a rare complication of primary Sjögren syndrome: report of 9 new cases and review of the literature.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1090986.544353 ◽

2007 ◽

Author(s):

Jay H Ryu

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Rare Complication ◽

Sjögren Syndrome ◽

Sjogren Syndrome ◽

Review Of The Literature ◽

Primary Sjögren Syndrome ◽

Pulmonary Arterial ◽

Syndrome Report

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AB0686 Association between the immunological profile of the patients with primary sjÖgren syndrome and occurrence of the extraglandular manifestations

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2012-eular.686 ◽

2013 ◽

Vol 71 (Suppl 3) ◽

pp. 677.18-677

Author(s):

M. Mazurek ◽

E. Wielosz ◽

M. Majdan

Keyword(s):

Sjögren Syndrome ◽

Sjogren Syndrome ◽

Extraglandular Manifestations ◽

Primary Sjögren Syndrome ◽

Immunological Profile

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Occult primary Sjögren Syndrome in patients with interstitial pneumonia with autoimmune features

Respiratory Medicine ◽

10.1016/j.rmed.2021.106405 ◽

2021 ◽

Vol 182 ◽

pp. 106405

Author(s):

Santiago Auteri ◽

María L. Alberti ◽

Martin E. Fernández ◽

Guadalupe Blanco ◽

Mercedes Rayá ◽

...

Keyword(s):

Interstitial Pneumonia ◽

Sjögren Syndrome ◽

Sjogren Syndrome ◽

Primary Sjögren Syndrome

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Abdominal symptoms during Sjogren’s syndrome: a pilot study

Advances in Rheumatology ◽

10.1186/s42358-021-00164-w ◽

2021 ◽

Vol 61 (1) ◽

Author(s):

Simon Parreau ◽

Jérémie Jacques ◽

Stéphanie Dumonteil ◽

Sylvain. Palat ◽

Sophie Geyl ◽

...

Keyword(s):

Symptom Score ◽

Activity Index ◽

Central Nervous System Involvement ◽

Disease Activity Index ◽

Sjögren Syndrome ◽

Sjogren Syndrome ◽

Primary Sjögren Syndrome ◽

Abdominal Symptoms ◽

Patient Reported ◽

Therapeutic Recommendation

Abstract Background Abdominal symptoms in patients with primary Sjögren syndrome (pSS) are poorly documented. The objective of the study was to describe the abdominal symptoms of patients with pSS and to assess their association with characteristics of the disease. Methods One hundred and fifty patients with pSS were evaluated using a composite global symptom score for abdominal symptoms and their severity. Data concerning the clinical and biological characteristics of pSS and abdominal disorders were also collected. Results Of the patients with pSS, 95% suffered from abdominal symptoms (median global symptom score 7.5 ± 5.5 points out of 30). More than half of the patients experienced abdominal tension (68%), upper abdominal pain (54%), abdominal discomfort (58%) and/or constipation (54%). Regarding the pSS activity, in relation to European League Against Rheumatism (EULAR) Sjögren syndrome disease activity index score items, general and central nervous system involvement wereassociated with a high global symptom score. The EULAR Sjogren Syndrome Patient Reported Index (ESSPRI) symptom score was positively correlated with the global symptom score (p < 0.01). Multivariate analysis showed a significant association between a high global symptom score and SSA seronegativity, gastroparesis, and ESSPRI score (p < 0.01 for each). Conclusions The majority of patients with pSS suffered abdominal symptoms. There is currently no therapeutic recommendation because of the lack of information on the underlying pathophysiological mechanisms. Trial registration NCT03157011. Date of registration: July 17, 2017.

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