Extensively drug-resistant Acinetobacter baumannii carrying blaOXA-23-like and armA in a hospital after an intervention in the intensive care unit which ended a long-standing endemicity

2020 ◽  
Author(s):  
Carlos Rodríguez-Lucas ◽  
M. Rosario Rodicio ◽  
Xenia Vázquez ◽  
Dolores Escudero ◽  
Brígida Quindós ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Acinetobacter Baumannii ◽  
Drug Resistant ◽  
Extensively Drug Resistant

scholarly journals Clonal spread of PER-1 and OXA-23 producing extensively drug resistant Acinetobacter baumannii during an outbreak in a burn intensive care unit in Tunisia

2020 ◽  
Author(s):  
Aymen Mabrouk ◽  
Yosra Chebbi ◽  
Anis Raddaoui ◽  
Asma Krir ◽  
Amen Allah Messadi ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Acinetobacter Baumannii ◽  
Genetic Relatedness ◽  
Burn Patients ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Total Dna ◽  
Clonal Spread ◽  
Encoding Genes

AbstractExtensively drug resistant Acinetobacter baumannii (XDR-Ab), has emerged as an important pathogen in several outbreaks. The aim of our study was to investigate the eventual genetic relatedness of XDR-Ab strains recovered from burn patients and environment sites in the largest Tunisian Burn Intensive Care Unit (BICU) and to characterize β-lactamase encoding genes in these strains. Between March 04th, 2019 and April 22nd, 2019 an outbreak of XDR-Ab was suspected. Environmental screening was done. All isolates were screened by simplex PCR for β-lactamase genes. Genetic relatedness was determined by pulsed field gel electrophoresis (PFGE) of ApaI-digested total DNA. During the study period, 21 strains of A. baumannii were isolated in burn patients, mainly in blood culture (n = 7) and central vascular catheter (n = 6). All strains were susceptible to colistin but resistant to imipenem (n = 23), ciprofloxacin (n = 23), amikacin (n = 22), tigecyclin (n = 5) and rifampicin (n = 4). The blaOXA-51-like, blaOXA23, and blaADC genes were present in all strains. These resistance determinants were associated with blaPER-1 in 10 strains. The ISAba1 was inserted upstream of blaOXA-23 in all isolates. PFGE revealed two major clusters A (n = 11) and B (n = 5). This is the first description in Tunisia of clonally related PER-1 producing XDR-Ab in burn patients with probable environmental origin.

scholarly journals Extensively drug-resistant Acinetobacter baumannii and Proteeae association in a Romanian intensive care unit: risk factors for acquisition

2018 ◽  
Vol Volume 11 ◽  
pp. 2187-2197 ◽  
Author(s):  
Delia Muntean ◽  
Monica Licker ◽  
Florin Horhat ◽  
Victor Dumitrașcu ◽  
Dorel Săndesc ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Acinetobacter Baumannii ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Unit Risk
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