In vitro evaluation of photodynamic therapy using curcumin on Leishmania major and Leishmania braziliensis

2016 ◽  
Vol 31 (5) ◽  
pp. 883-890 ◽  
Author(s):  
Juliana Guerra Pinto ◽  
Letícia Correa Fontana ◽  
Marco Antonio de Oliveira ◽  
Cristina Kurachi ◽  
Leandro José Raniero ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Leishmania Major ◽  
Leishmania Braziliensis ◽  
In Vitro Evaluation

Polylactide-Based Block Copolymeric Micelles Loaded with Chlorin e6 for Photodynamic Therapy: In Vitro Evaluation in Monolayer and 3D Spheroid Models

2017 ◽  
Vol 14 (11) ◽  
pp. 3789-3800 ◽  
Author(s):  
Preeti Kumari ◽  
Shreya Jain ◽  
Balaram Ghosh ◽  
Vladimir Zorin ◽  
Swati Biswas
Keyword(s):  
Photodynamic Therapy ◽  
Chlorin E6 ◽  
In Vitro Evaluation

Screening and In Vitro Evaluation of Mucoadhesive Thermoresponsive System Containing Methylene Blue for Local Photodynamic Therapy of Colorectal Cancer

2015 ◽  
Vol 33 (3) ◽  
pp. 776-791 ◽  
Author(s):  
Fernanda Belincanta Borghi-Pangoni ◽  
Mariana Volpato Junqueira ◽  
Sabrina Barbosa de Souza Ferreira ◽  
Larissa Lachi Silva ◽  
Bruno Ribeiro Rabello ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Methylene Blue ◽  
Photodynamic Therapy ◽  
In Vitro Evaluation

scholarly journals AVALIAÇÃO DA TERAPIA FOTODINÂMICA COM AZUL DE METILENO EM Leishmania major e Leishmania braziliensis: ESTUDO in vitro

2017 ◽  
Vol 22 (40) ◽  
pp. 649
Author(s):  
Danielle El Atra Coelho ◽  
Letícia Corrêa Fontana ◽  
Juliana Guerra Pinto ◽  
Juliana Ferreira-Strixino
Keyword(s):  
Leishmania Major ◽  
Leishmania Braziliensis

A Leishmaníase é uma doença crônica causada pelo protozoário do gênero Leishmania, cujo tratamento é agressivo. A Terapia Fotodinâmica (TFD) é uma alternativa promissora que combina luz, fotossensibilizador (FS) e oxigênio molecular, para causar a morte celular. O objetivo desse trabalho foi avaliar, in vitro, a ação da TFD com Azul de metileno (AM) em promastigotas de Leishmania, por teste de MTT, curva de crescimento e morfologia do parasito. O teste de MTT demonstrou alteração de ambas as espécies após interação com o AM no escuro e após TFD. A análise das curvas demonstrou que a TFD influenciou o crescimento das espécies. A análise morfológica revelou que o AM no escuro não causou alterações expressivas como a TFD, sendo a cepa de L. braziliensis mais afetada que a cepa de L. major. Pode-se concluir que a TFD com AM foi promissora contra promastigotas de Leishmania, pois foi capaz de diminuir o crescimento e alterar a morfologia dos parasitos em cultura.

Synthesis and In Vitro Evaluation of Anti‐Leukemic Potency of Some Novel Azo‐Naphthol Dyes Conjugated with Metal Nanoparticles as Photosensitizers for Photodynamic Therapy

2020 ◽  
Vol 5 (28) ◽  
pp. 8609-8615 ◽  
Author(s):  
Mohamed E. Khalifa ◽  
Elham A. Elkhawass ◽  
Masayuki Ninomiya ◽  
Kaori Tanaka ◽  
Mamoru Koketsu
Keyword(s):  
Photodynamic Therapy ◽  
Metal Nanoparticles ◽  
In Vitro Evaluation

In vitro evaluation of methylene blue removal from root canal after Photodynamic Therapy

2017 ◽  
Vol 20 ◽  
pp. 248-252 ◽  
Author(s):  
Karen Müller Ramalho ◽  
Sandra Ribeiro Cunha ◽  
Eric Mayer-Santos ◽  
Carlos de Paula Eduardo ◽  
Patricia Moreira de Freitas ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Root Canal ◽  
In Vitro Evaluation ◽  
Methylene Blue Removal

Photodynamic activity of Photogem® in Leishmania promastigotes and infected macrophages

2021 ◽  
Vol 16 (2) ◽  
pp. 95-106
Author(s):  
Juliana G Pinto ◽  
Luciana MC Marcolino ◽  
Juliana Ferreira-Strixino
Keyword(s):  
Photodynamic Therapy ◽  
Leishmania Major ◽  
Mitochondrial Activity ◽  
Leishmania Braziliensis ◽  
Morphological Alterations ◽  
Photodynamic Activity ◽  
Leishmania Promastigotes ◽  
Macrophage Viability

Objectives: This study aimed to evaluate the effect of photodynamic therapy (PDT) with Photogem® in promastigotes of Leishmania braziliensis and Leishmania major, and in infected macrophages. Materials & methods: The following parameters were analyzed: Photogem® internalization, mitochondrial activity, viability, tubulin marking and morphological alterations in promastigotes and viability in infected macrophages. Results: Photogem® accumulated in the cytosol and adhered to the flagellum. Changes were observed in the mitochondrial activity in groups maintained in the dark, with no viability alteration. After PDT, viability decreased up to 80%, and morphology was affected. Conclusion: The results point out that PDT with Photogem® can reduce parasite and macrophage viability.

Synthesis, photophysical properties and in vitro evaluation of a chlorambucil conjugated ruthenium(ii) complex for combined chemo-photodynamic therapy against HeLa cells

2017 ◽  
Vol 5 (24) ◽  
pp. 4623-4632 ◽  
Author(s):  
Jing-Xiang Zhang ◽  
Mei Pan ◽  
Cheng-Yong Su
Keyword(s):  
Photodynamic Therapy ◽  
Hela Cells ◽  
Photophysical Properties ◽  
Inhibitory Effect ◽  
Antiproliferative Effect ◽  
In Vitro Evaluation

We designed a new heteroleptic Ru(ii) complex CHL-RuL as an imaging-guided chemotherapy/PDT agent, which shows a moderate antiproliferative effect in dark and strong photodynamic inhibitory effect against HeLa cells.

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