scholarly journals The revised version 2018 of the nationwide web-based registry system for kidney diseases in Japan: Japan Renal Biopsy Registry and Japan Kidney Disease Registry

2020 ◽  
Vol 24 (11) ◽  
pp. 1058-1068
Author(s):  
Takaya Ozeki ◽  
◽  
Shoichi Maruyama ◽  
Michio Nagata ◽  
Akira Shimizu ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Renal Biopsy ◽  
Kidney Diseases ◽  
Immunosuppressive Treatment ◽  
Laboratory Data ◽  
First Year ◽  
Disease Registry ◽  
Web Based ◽  
Registry System ◽  
Almost All

Abstract Background The Japan Renal Biopsy Registry (J-RBR), the first nation-wide registry of renal biopsies in Japan, was established in 2007, and expanded to include non-biopsy cases as the Japan Kidney Disease Registry (J-KDR) in 2009. The J-RBR/J-KDR is one of the biggest registries for kidney diseases. It has revealed the prevalence and distribution of kidney diseases in Japan. This registry system was meant to be revised after 10 years. Methods In 2017, the Committees of the Japanese Society of Nephrology started a project for the revision of the J-RBR/J-KDR. The revised system was designed in such a way that the diagnoses of the patients could be selected from the Diagnosis Panel, a list covering almost all known kidney diseases, and focusing on their pathogenesis rather than morphological classification. The Diagnosis Panel consists of 22 categories (18 glomerular, 1 tubulointerstitial, 1 congenital/genetical, 1 transplant related, and 1 other) and includes 123 diagnostic names. The items for clinical diagnosis and laboratory data were also renewed, with the addition of the information on immunosuppressive treatment. Results The revised version of J-RBR/J-KDR came into use in January 2018. The number of cases registered under the revised system was 2748 in the first year. The total number of cases has reached to 43,813 since 2007. Conclusion The revised version 2018 J-RBR/J-KDR system attempts to cover all kidney diseases by focusing on their pathogenesis. It will be a new platform for the standardized registration of kidney biopsy cases that provides more systemized data of higher quality.

scholarly journals C3 and C4 Complements in Glomerular Disorders in Children

2017 ◽  
Vol 18 (3-4) ◽  
pp. 75
Author(s):  
H. Alatas ◽  
I.G.N. Wila Wirya ◽  
T. Tambunan
Keyword(s):  
Nephrotic Syndrome ◽  
Child Health ◽  
Normal Level ◽  
Membranoproliferative Glomerulonephritis ◽  
Kidney Diseases ◽  
Immunosuppressive Treatment ◽  
The Other ◽  
Poststreptococcal Glomerulonephritis ◽  
Acute Poststreptococcal Glomerulonephritis ◽  
Almost All

Seventy children who were hospitalized for kidney diseases in the Nephrological ward Department of Child Health, University of Indonesia, Jakarta were used in this study. Thirty seven patients sufferfng from acute poststreptococcal Glomerulonephritis (A.G.N.), 3 patients with Membranoproliferative Glomerulonephritis (M.P.G.N.) and 30 patients with Nephrotic Syndrome due to other causes were examined for complement concentration. A total of 80 samples were examined for C3 and 25 samples for C4 concentration using the immunediffusion plates. Almost all patients with A.G.N. and M.P.G.N. showed depression of C3. C4 concentration was normal except in 2 patients, 1 with A.G.N. and the other With M.P.G.N. This suggest activation of complement at the C3 level by the alternating pathway in most of the patients. C3 concentration in A.G.N. patients returned to normal after 8-10 weeks. In MPGN the depression was persistent in 2 patients, while in 1 patient it returned to normal level after 3 months of Immunosuppressive treatment.

scholarly journals Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010

2013 ◽  
Vol 17 (2) ◽  
pp. 155-173 ◽  
Author(s):  
Hitoshi Sugiyama ◽  
◽  
Hitoshi Yokoyama ◽  
Hiroshi Sato ◽  
Takao Saito ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Renal Biopsy ◽  
Committee Report ◽  
Disease Registry

scholarly journals SAT-412 TEN-YEAR TRENDS IN DIAGNOSIS OF KIDNEY DISEASES IN JAPAN -THE JAPAN KIDENY DISEASE REGISTRY/JAPAN RENAL BIOPSY REGISTRY (J-KDR/J-RBR)

2020 ◽  
Vol 5 (3) ◽  
pp. S172
Author(s):  
S. Maruyama ◽  
K. Goto ◽  
T. Ozeki ◽  
H. Yokoyama ◽  
H. Sugiyama ◽  
...  
Keyword(s):  
Renal Biopsy ◽  
Kidney Diseases ◽  
Disease Registry

scholarly journals 2. Epidemiology of Renal Disease: Japan Renal Biopsy Registry and Japan Kidney Disease Registry

2013 ◽  
Vol 102 (5) ◽  
pp. 1083-1091 ◽  
Author(s):  
Hitoshi Sugiyama ◽  
Hiroshi Sato ◽  
Yoshihiko Ueda ◽  
Hitoshi Yokoyama
Keyword(s):  
Kidney Disease ◽  
Renal Disease ◽  
Renal Biopsy ◽  
Disease Registry

scholarly journals COVID-19 and kidney diseases: A meta-analysis of clinical outcomes

2021 ◽  
pp. 53-66
Author(s):  
Fateme Shamekhi Amiri
Keyword(s):  
Kidney Disease ◽  
Effect Size ◽  
Kidney Diseases ◽  
Meta Analysis ◽  
Graft Loss ◽  
Laboratory Data ◽  
Medium Effect ◽  
Study Results ◽  
Acute Kidney Disease

Abstract. Novel coronavirus 2019 (COVID-19) is a highly infectious disease that causes multiorgan failure and a high mortality rate. The present study aimed to investigate the association between COVID-19 infection and kidney dysfunction.Methods. In this meta-analysis study, 68 patients with kidney dysfunction and COVID-19 infection were analysed. Clinical features, laboratory data at initial presentation, management and, outcomes were collected. Risk of acute kidney injury (AKI), acute kidney disease (AKD) and chronic kidney disease (CKD) progression to kidney replacement therapy and graft loss were primary outcomes in this study. Results. The average age of patients at the time of diagnosis in COVID-19 nephropathy was 52.04 ± 14.42 years. There were ICU admission in 10/68 (14.7%) patients with COVID-19 nephropathy. There were a need for mechanical ventilation in 13/68 (19.1%) patients; 15/68 (22%) patients died during hospital course or post-discharge. There were AKI in 4/68 (5.8%) patients with COVID-19 nephropathy and AKD found in 14/68 (20.5%) patients with COVID-19 nephropathy during the follow-up. The median and interquartile range of SCr during the follow-up period was assessed at 1.74 mg/dl and 1.18 (Q3-Q1=2.73-1.55), respectively. The effect size of COVID-19 on AKI and AKD was assessed 0 and 0.003 using Cohen᾽s-d test. Eventually, 10 of 68 (14.7%) patients with COVID-19 nephropathy stayed on hemodialysis during the follow-up period and one of them remained on RRT but its type was not characterized. There were a total of 36/68 (52.9%) kidney transplant recipients and 10/36 (27.7%) of them developed AKI due to acute rejection. The effect size of elevated IL-6 on decreased estimated glomerular filtration rate (eGFR) in COVID-19 nephropathy was assessed 0.656 (medium effect size). Conclusion. The COVID-19 had a trivial (small) effect on eGFR declining. Future clinical research is required for investigating novel unknown findings in COVID-19 nephropathy.

scholarly journals Integration of genetic and histopathology data in interpretation of kidney disease

2020 ◽  
Vol 35 (7) ◽  
pp. 1113-1132
Author(s):  
Susan L Murray ◽  
Neil K Fennelly ◽  
Brendan Doyle ◽  
Sally Ann Lynch ◽  
Peter J Conlon
Keyword(s):  
Kidney Disease ◽  
Renal Biopsy ◽  
Kidney Diseases ◽  
Genomic Medicine ◽  
Disease Diagnosis ◽  
Diagnostic Information ◽  
Significant Burden ◽  
Diagnostic Modalities ◽  
Enhance Patient Care ◽  
Inherited Kidney Disease

Abstract For many years renal biopsy has been the gold standard for diagnosis in many forms of kidney disease. It provides rapid, accurate and clinically useful information in most individuals with kidney disease. However, in recent years, other diagnostic modalities have become available that may provide more detailed and specific diagnostic information in addition to, or instead of, renal biopsy. Genomics is one of these modalities. Previously prohibitively expensive and time consuming, it is now increasingly available and practical in a clinical setting for the diagnosis of inherited kidney disease. Inherited kidney disease is a significant cause of kidney disease, in both the adult and paediatric populations. While individual inherited kidney diseases are rare, together they represent a significant burden of disease. Because of the heterogenicity of inherited kidney disease, diagnosis and management can be a challenge and often multiple diagnostic modalities are needed to arrive at a diagnosis. We present updates in genomic medicine for renal disease, how genetic testing integrates with our knowledge of renal histopathology and how the two modalities may interact to enhance patient care.

Syphilis

2015 ◽  
Author(s):  
Emmanuel A. Burdmann
Keyword(s):  
Infectious Disease ◽  
Kidney Disease ◽  
Antibiotic Therapy ◽  
Renal Biopsy ◽  
Congenital Syphilis ◽  
Kidney Diseases ◽  
Transmission Route ◽  
Infected Blood ◽  
Clinical Presentations ◽  
Membranous Glomerulopathy

Syphilis is an infectious disease caused by the bacterium Treponema pallidum. The transmission route is usually sexual, but prenatal contamination (congenital syphilis) and transmission by infected blood can also occur. The most frequent presentation of syphilis nephropathy is proteinuria, and the most common form of associated glomerular disease is membranous glomerulopathy. Kidney disease usually reverts with antibiotic therapy. Syphilis must always be considered in proteinuric HIV-infected patients. Renal biopsy is necessary to differentiate between HIV-associated nephropathy and syphilis-induced glomerulopathies, since both kidney diseases have analogous clinical presentations, but syphilis-induced glomerulopathies may recover with syphilis successful treatment.

Approach to the Patient with Kidney Disease

2018 ◽  
Author(s):  
Mustafa Arici
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Renal Biopsy ◽  
Glomerular Filtration ◽  
Kidney Function ◽  
Filtration Rate ◽  
Kidney Diseases ◽  
Risk Of Progression

Chronic kidney disease (CKD) has diverse presentations that are frequently subclinical early in its course but symptomatic in more advanced stages. Quite commonly, kidney disease is diagnosed as an incidental finding in blood or urine tests. It is therefore crucial to understand how to assess kidney function tests and know the diverse presentations of kidney diseases in clinical practice. Assessment of kidney function mainly comprises three important steps: measuring glomerular filtration rate (GFR), estimation of urine albumin or protein excretion, and urinalysis/sediment examination. Estimating GFR based on a filtration marker (usually serum creatinine) is now widely accepted as the initial test. Several GFR prediction equations that use serum creatinine or other filtration markers along with certain patient characteristics (such as age, gender, and race) are used to estimate GFR, though several limitations must be considered when interpreting their results. Measurement of proteinuria or albuminuria provides insights into etiology (glomerular versus other parenchymal kidney diseases) and an assessment of risk of progression (ie, greater proteinuria, higher risk of progression). A complete examination of urine should be performed in all kidney patients. Urinalysis/sediment examination provides important information for both differential diagnosis of acute kidney disease (AKD) and CKD and clues for underlying etiologies of kidney disease. Several serologic tests and selected imaging studies complement the assessment of kidney diseases. Renal biopsy is occasionally required to specify the exact diagnosis and direct the treatment. All these investigations should be performed to determine the duration of kidney disease (ie, acute or chronic), designate the specific etiology, assess the risk for progression, and evaluate the presence of complications. Recently, several risk stratification scores or prediction models were developed for early diagnosis or predicting prognosis of acute kidney injury or CKD. These risk models may help to decrease the huge burden of kidney diseases on the individual as well as social level. This review contains 1 figure, 11 tables and 29 references Key Words: albumin-creatinine ratio, albuminuria, biomarkers, eGFR, chronic kidney disease, cystatin C, history, imaging, glomerular filtration rate , physical examination, renal biopsy, serum creatinine, urinalysis

scholarly journals Japan Renal Biopsy Registry: the first nationwide, web-based, and prospective registry system of renal biopsies in Japan

2011 ◽  
Vol 15 (4) ◽  
pp. 493-503 ◽  
Author(s):  
Hitoshi Sugiyama ◽  
◽  
Hitoshi Yokoyama ◽  
Hiroshi Sato ◽  
Takao Saito ◽  
...  
Keyword(s):  
Renal Biopsy ◽  
Web Based ◽  
Registry System ◽  
Renal Biopsies
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