PPAR-δ activation reduces cisplatin-induced apoptosis via inhibiting p53/Bax/caspase-3 pathway without modulating autophagy in murine renal proximal tubular cells

2021 ◽  
Author(s):  
Juanping Shan ◽  
Hideki Kimura ◽  
Seiji Yokoi ◽  
Kazuko Kamiyama ◽  
Toru Imamoto ◽  
...  
Keyword(s):  
Caspase 3 ◽  
Proximal Tubular Cells ◽  
Tubular Cells ◽  
Proximal Tubular ◽  
Renal Proximal Tubular Cells ◽  
Renal Proximal Tubular ◽  
Induced Apoptosis

Activation of liver X receptors inhibits cadmium-induced apoptosis of human renal proximal tubular cells

2015 ◽  
Vol 236 (3) ◽  
pp. 145-153 ◽  
Author(s):  
Somsak Fongsupa ◽  
Sirima Soodvilai ◽  
Chatchai Muanprasat ◽  
Varanuj Chatsudthipong ◽  
Sunhapas Soodvilai
Keyword(s):  
Liver X Receptors ◽  
Proximal Tubular Cells ◽  
Tubular Cells ◽  
Proximal Tubular ◽  
Renal Proximal Tubular Cells ◽  
Renal Proximal Tubular ◽  
X Receptors ◽  
Induced Apoptosis

F-actin disorganization in apoptotic cell death of cultured rat renal proximal tubular cells

1996 ◽  
Vol 270 (4) ◽  
pp. F593-F603 ◽  
Author(s):  
B. Van de Water ◽  
M. Kruidering ◽  
J. F. Nagelkerke
Keyword(s):  
Apoptotic Cell ◽  
Dna Fragments ◽  
Proximal Tubular Cells ◽  
Tubular Cells ◽  
Lactate Dehydrogenase Release ◽  
Fragmented Nucleus ◽  
Proximal Tubular ◽  
Renal Proximal Tubular Cells ◽  
Renal Proximal Tubular ◽  
Induced Apoptosis

The mechanism of nephrotoxin-induced apoptosis was studied in rat renal proximal tubular cells (PTC) exposed to the nephrotoxin S-(1,2-dichlorovinyl)-L-cysteine (DCVC). After a 6-h incubation, DCVC caused a condensation of heterochromatin and a fragmentation of the nucleus in 84 and 16% of the cells, respectively, which is indicative of apoptosis. This was confirmed biochemically by agarose gel electrophoresis demonstrating the formation of DNA fragments with multiples of 200 bp. The antioxidant N,N'-diphenyl-p-phenylenediamine prevented neither the fragmentation of the nucleus nor the formation of DNA fragments, but it did prevent lactate dehydrogenase release and bleb formation by DCVC. Apoptosis induced by DCVC was closely associated with F-actin disorganization: every cell with a fragmented nucleus displayed completely disorganized F-actin, while cells with a normal nucleus still possessed at least some intact F-actin also induced apoptosis in PTC. Similarly, dithiothreitol, which damages F-actin in PTC, caused apoptosis of PTC. These data suggest a causal relationship between F-actin disorganization and apoptosis of PTC.

scholarly journals Pinostrobin attenuates colistin-induced apoptosis of human renal proximal tubular cells

2021 ◽  
Vol 48 (6) ◽  
pp. 549-556
Author(s):  
Nichakorn Worakajit ◽  
Penjai Thongnuanjan ◽  
Napason Chabang ◽  
Sirima Soodvilai ◽  
Patoomratana Tuchinda ◽  
...  
Keyword(s):  
Proximal Tubular Cells ◽  
Tubular Cells ◽  
Proximal Tubular ◽  
Renal Proximal Tubular Cells ◽  
Renal Proximal Tubular ◽  
Induced Apoptosis
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