A hypothesis to account for the selective and diverse actions of neonicotinoid insecticides at their molecular targets, nicotinic acetylcholine receptors: catch and release in hydrogen bond networks

2007 ◽  
Vol 7 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Makoto Ihara ◽  
Masaru Shimomura ◽  
Chiharu Ishida ◽  
Hisashi Nishiwaki ◽  
Miki Akamatsu ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Molecular Targets ◽  
Nicotinic Acetylcholine ◽  
Neonicotinoid Insecticides ◽  
Catch And Release ◽  
Hydrogen Bond Networks

scholarly journals Neonicotinoid insecticides display partial and super agonist actions on native insect nicotinic acetylcholine receptors

2006 ◽  
Vol 99 (2) ◽  
pp. 608-615 ◽  
Author(s):  
Laurence A. Brown ◽  
Makoto Ihara ◽  
Steven D. Buckingham ◽  
Kazuhiko Matsuda ◽  
David B. Sattelle
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Nicotinic Acetylcholine ◽  
Neonicotinoid Insecticides

scholarly journals An Overview on the Effect of Neonicotinoid Insecticides on Mammalian Cholinergic Functions through the Activation of Neuronal Nicotinic Acetylcholine Receptors

2020 ◽  
Vol 17 (9) ◽  
pp. 3222 ◽  
Author(s):  
Jean-Noël Houchat ◽  
Alison Cartereau ◽  
Anaïs Le Mauff ◽  
Emiliane Taillebois ◽  
Steeve H. Thany
Keyword(s):  
Neurodegenerative Diseases ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Rat Striatum ◽  
Neuronal Nicotinic Acetylcholine Receptors ◽  
Nicotinic Acetylcholine ◽  
Neonicotinoid Insecticides ◽  
High Affinity ◽  
Cholinergic Synaptic Transmission ◽  
Neuronal Distribution

Neonicotinoid insecticides are used worldwide and have been demonstrated as toxic to beneficial insects such as honeybees. Their effectiveness is predominantly attributed to their high affinity for insect neuronal nicotinic acetylcholine receptors (nAChRs). Mammalian neuronal nAChRs are of major importance because cholinergic synaptic transmission plays a key role in rapid neurotransmission, learning and memory processes, and neurodegenerative diseases. Because of the low agonist effects of neonicotinoid insecticides on mammalian neuronal nAChRs, it has been suggested that they are relatively safe for mammals, including humans. However, several lines of evidence have demonstrated that neonicotinoid insecticides can modulate cholinergic functions through neuronal nAChRs. Major studies on the influence of neonicotinoid insecticides on cholinergic functions have been conducted using nicotine low-affinity homomeric α7 and high-affinity heteromeric α4β2 receptors, as they are the most abundant in the nervous system. It has been found that the neonicotinoids thiamethoxam and clothianidin can activate the release of dopamine in rat striatum. In some contexts, such as neurodegenerative diseases, they can disturb the neuronal distribution or induce oxidative stress, leading to neurotoxicity. This review highlights recent studies on the mode of action of neonicotinoid insecticides on mammalian neuronal nAChRs and cholinergic functions.

Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity

2020 ◽  
Vol 60 (1) ◽  
pp. 241-255 ◽  
Author(s):  
Kazuhiko Matsuda ◽  
Makoto Ihara ◽  
David B. Sattelle
Keyword(s):  
Adverse Effects ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Insect Pests ◽  
Molecular Targets ◽  
Nicotinic Acetylcholine ◽  
Nontarget Organisms ◽  
Beneficial Insects ◽  
Enhanced Resistance ◽  
New Generation

Neonicotinoids have been used to protect crops and animals from insect pests since the 1990s, but there are concerns regarding their adverse effects on nontarget organisms, notably on bees. Enhanced resistance to neonicotinoids in pests is becoming well documented. We address the current understanding of neonicotinoid target site interactions, selectivity, and metabolism not only in pests but also in beneficial insects such as bees. The findings are relevant to the management of both neonicotinoids and the new generation of pesticides targeting insect nicotinic acetylcholine receptors.

Nicotinic acetylcholine receptors in the patients with Parkinson's disease: 5IA-SPECT

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S586-S586 ◽  
Author(s):  
Kazuo Hashikawa ◽  
Hidefumi Yoshida ◽  
Nobukatsu Sawamoto ◽  
Shigetoshi Takaya ◽  
Chihiro Namiki ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Nicotinic Acetylcholine
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