Resistance to Neurodegenerative Brain Damage in August and Wistar Rats

2005 ◽  
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A. V. Goryacheva ◽  
...  
1996 ◽  
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M. V. Shimkovich ◽  
E. V. Malysheva ◽  
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2018 ◽  
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ME Erdemli ◽  
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Z Aksungur ◽  
S Gul ◽  
...  
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2015 ◽  
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L. I. Krupitskaya ◽  
A. I. Sinitskii ◽  
L. I. Kolesnikova

2018 ◽  
Vol 118 ◽  
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J.A. Santos-López ◽  
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1997 ◽  
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Diego Nery Benevides Gadelha ◽  
Neylane Nyeria Coelho Batista Gadelha ◽  
Thárcia Kiara Beserra Oliveira ◽  
...  

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Eduitem S. Otong ◽  
Sunday A. Musa ◽  
Barnabas Danborno ◽  
Sohnap J. Sambo

Aim: The current study seeks to explore the neuroprotective benefits of Adansonia digitata against lead induced memory impairment, neurotransmitter/AChE activity imbalance, oxidative stress as well as brain damage. Methodology: Thirty male adult rats weighing 160g-200g were divided randomly into six groups (I-V1) consisting of five (5) rats in each group. Group I served as control and were administered with distilled water (1 ml/kg) only while groups II -VI were treatment groups. Group II were administered 250 mg/kg of Adansonia digitata; group III were administered 30 mg/kg of lead; Group IV were administered 250 mg/kg of Adansonia digitata plus 30 mg/kg of lead; Group V were administered 500 mg/kg of Adansonia digitata plus 30 mg/kg of lead; Group VI were administered 30 mg/kg of lead plus 10 mg/kg of succimer. All administrations were carried out through oral gavage for a period of 28 days. Results: Lead administration caused memory impairment, decreased dopamine concentration and AChE activity in brain, induced oxidative stress resulting in brain damage.  Adansonia digitata treatment significantly (P<.001) attenuated memory impairment, modulated dopamine concentration and AChE activity, prevented oxidative stress and ameliorated histopathological changes in the brain of Wistar rats. Conclusion: The result showed that Adansonia digitata ameliorates lead-induced memory impairment in Wistar rats by improving memory index, controlling dopamine concentration and AChE activity, preventing oxidative stress and neuronal degeneration.


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