Neuroprotection against CCl4induced brain damage with crocin in Wistar rats

2018 ◽  
Vol 93 (8) ◽  
pp. 623-631 ◽  
Author(s):  
E Altinoz ◽  
ME Erdemli ◽  
M Gul ◽  
Z Aksungur ◽  
S Gul ◽  
...  
Keyword(s):  
Brain Damage ◽  
Wistar Rats

Can nonalcoholic beer, silicon and hops reduce the brain damage and behavioral changes induced by aluminum nitrate in young male Wistar rats?

2018 ◽  
Vol 118 ◽  
pp. 784-794 ◽  
Author(s):  
P. Merino ◽  
J.A. Santos-López ◽  
C.J. Mateos ◽  
I. Meseguer ◽  
A. Garcimartín ◽  
...  
Keyword(s):  
Brain Damage ◽  
Wistar Rats ◽  
Young Male ◽  
Behavioral Changes ◽  
Aluminum Nitrate ◽  
Male Wistar Rats ◽  
The Brain

scholarly journals Brain damage and congenital cataract due to autogenously fecal peritonitis in pregnant Wistar rats

2014 ◽  
Vol 29 (10) ◽  
pp. 681-687 ◽  
Author(s):  
Carlos Teixeira Brandt ◽  
Maria Cecília Santos Cavalcanti Melo ◽  
Diego Nery Benevides Gadelha ◽  
Neylane Nyeria Coelho Batista Gadelha ◽  
Thárcia Kiara Beserra Oliveira ◽  
...  
Keyword(s):  
Brain Damage ◽  
Wistar Rats ◽  
Congenital Cataract ◽  
Fecal Peritonitis

scholarly journals Mitigation of Lead Neurotoxicity by Aqueous Fruit Extract of Adansonia digitata in Adult Wistar Rats

2021 ◽  
pp. 71-82
Author(s):  
Eduitem S. Otong ◽  
Sunday A. Musa ◽  
Barnabas Danborno ◽  
Sohnap J. Sambo
Keyword(s):  
Oxidative Stress ◽  
Brain Damage ◽  
Memory Impairment ◽  
Ache Activity ◽  
Wistar Rats ◽  
Neuronal Degeneration ◽  
Adansonia Digitata ◽  
Male Adult ◽  
Dopamine Concentration ◽  
Group I

Aim: The current study seeks to explore the neuroprotective benefits of Adansonia digitata against lead induced memory impairment, neurotransmitter/AChE activity imbalance, oxidative stress as well as brain damage. Methodology: Thirty male adult rats weighing 160g-200g were divided randomly into six groups (I-V1) consisting of five (5) rats in each group. Group I served as control and were administered with distilled water (1 ml/kg) only while groups II -VI were treatment groups. Group II were administered 250 mg/kg of Adansonia digitata; group III were administered 30 mg/kg of lead; Group IV were administered 250 mg/kg of Adansonia digitata plus 30 mg/kg of lead; Group V were administered 500 mg/kg of Adansonia digitata plus 30 mg/kg of lead; Group VI were administered 30 mg/kg of lead plus 10 mg/kg of succimer. All administrations were carried out through oral gavage for a period of 28 days. Results: Lead administration caused memory impairment, decreased dopamine concentration and AChE activity in brain, induced oxidative stress resulting in brain damage.  Adansonia digitata treatment significantly (P<.001) attenuated memory impairment, modulated dopamine concentration and AChE activity, prevented oxidative stress and ameliorated histopathological changes in the brain of Wistar rats. Conclusion: The result showed that Adansonia digitata ameliorates lead-induced memory impairment in Wistar rats by improving memory index, controlling dopamine concentration and AChE activity, preventing oxidative stress and neuronal degeneration.

Ameliorative effects of Coccinia grandis leaf extract on Diabetes-Induced alterations of glucose metabolism, Cox activity and histological changes in Brain of Wistar Rats

2021 ◽  
Vol 12 (3) ◽  
pp. 1967-1976
Author(s):  
Bhaskar Nagilla ◽  
Bharathi Appidi ◽  
Pratap Reddy K
Keyword(s):  
Atpase Activity ◽  
Brain Damage ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Diabetic Rats ◽  
Sorbitol Dehydrogenase ◽  
Sodium Potassium ◽  
Reference Drug ◽  
Coccinia Grandis ◽  
Potassium Atpase

Coccinia grandis has been used in tribal populations of India both as food and medicine, but it has been not reported to be a neuroprotective agent yet. The present study was designed to evaluate the protective effects of Coccinia grandis leaf extract on diabetes induced brain damage of Wistar rats. This study reports the protective effect of methanolic leaf extract of Coccinia grandis against STZ induced diabetes in rats. Metformin (150mg/kg body wt.) was used as a reference drug. The enzymes of the polyol pathway and its related substrates were studied in the brain tissue. The effect of Coccinia on Cyclooxygenase (COX) and Prostaglandin peroxidise (PG) was also studied. Diabetes induced rats showed a significantly increased activity of Aldose reductase, Sorbitol dehydrogenase, Glucose-6-phosphodehydrogenase, whereas the decreased activity of Hexokinase. The content of Glucose, Sorbitol significantly increased in rat brain. Sodium potassium ATPase activity was also decreased in diabetic rats. COX, PG peroxidase was increased. Histological alternations were induced in the hippocampus of STZ treated diabetic rats. Oral administration of Coccinia leaf extract (200mg/kg) of body weight to diabetic rats for 21 days efficiently attenuated the parameters studied. A decreased activity of brain AR, sorbitol dehydrogenase, glucose-6-dehydrogenase was observed along with the increase in Hexokinase and Sodium potassium ATPase activity. It also showed decreased content of glucose and Sorbitol. Diabetes induced brain damage in the hippocampus and cerebral cortex was restored with Coccinia treatment. Decreased COX and PG peroxidase suggest its protection against inflammation. The current results suggest that Coccinia grandis leaf extract exerts the potential ability to reverse the progression of hyperglycemia and its concomitant induced brain damage.

Resistance to Neurodegenerative Brain Damage in August and Wistar Rats

2005 ◽  
Vol 139 (5) ◽  
pp. 540-542 ◽  
Author(s):  
M. G. Pshennikova ◽  
E. V. Popkova ◽  
I. P. Khomenko ◽  
E. B. Manukhina ◽  
A. V. Goryacheva ◽  
...  
Keyword(s):  
Brain Damage ◽  
Wistar Rats ◽  
August And Wistar Rats

Ultrastructural Investigation of Spontaneous Pituitary Adenomas in Aging Sprague-Dawley Rats

1982 ◽  
Vol 40 ◽  
pp. 216-217
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Microscopic Study ◽  
Pituitary Adenomas ◽  
Wistar Rats ◽  
Microscopic Level ◽  
Sprague Dawley ◽  
Prolactin Cells ◽  
Light Microscopic Level ◽  
Ultrastructural Investigation ◽  
Sprague Dawley Rats ◽  
Long Evans

Investigation of the spontaneous pituitary adenomas in rat have been limited mainly to light microscopic study. Furth et al. (1973) described them as chromophobic, secreting prolactin. Kovacs et al. (1977) in an ul trastructural investigation of adenomas of old female Long-Evans rats, found that they were composed of prolactin cells. Berkvens et al. (1980) using immunocytochemistry at the light microscopic level, demonstrated that some spontaneous tumors of old Wistar rats could contain GH, TSH or ACTH as well as PRL.

Light and electron microscopic investigation of adenohypophyses of germfree, food-restricted, and germfree-food restricted aging, male lobund-wistar rats

1988 ◽  
Vol 46 ◽  
pp. 352-353
Author(s):  
G. Ilse ◽  
K. Kovacs ◽  
N. Ryan ◽  
T. Sano ◽  
L. Stefaneanu ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Microscopic Investigation ◽  
Electron Microscopic Investigation ◽  
Aging Male ◽  
Sprague Dawley ◽  
Electron Microscopic ◽  
Sprague Dawley Rats ◽  
Old Rats ◽  
Ad Libitum ◽  
Microscopic Findings

Germfree state and food restriction have been shown to increase life span and delay tumor occurrence in rats. We report here the histologic, immunocytochemical and electron microscopic findings of adenohypophyses of aging, male Lobund-Wistar rats raised at Lobund Laboratories. In our previous study, the morphologic changes in the adenohypophyses of old rats have been extensively investigated by histology, immunocytochemistry and electron microscopy. Lactotroph adenomas were frequent in Long-Evans and Sprague-Dawley rats, whereas gonadotroph adenomas were frequent in Sprague-Dawley and Wistar rats.Male Lobund-Wistar rats were divided into four groups: 1) conventional, which were raised under normal non-germfree environment and received food ad libitum; 2) germfree-food ad libitum; 3) conventional environment-food restricted and 4) germfree-food restricted. The adenohypophyses were removed from 6-month-, 18-month- and 30-month-old rats. For light microscopy, adenohypophyses were fixed in formalin and embedded in paraffin.

Surface epithelial ultrastructure of the polycystic ovary in the BB wistar rat

1986 ◽  
Vol 44 ◽  
pp. 252-253
Author(s):  
R. C. Kaufmann ◽  
F. K. Khosho ◽  
K. S. Amankwah
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Wistar Rats ◽  
Polycystic Ovary ◽  
Wistar Rat ◽  
Polycystic Ovaries ◽  
Chemical Diabetes ◽  
Scanning Electron

Diabetes decreases the fertility of females, but the mechanisms are not completely understood. In our investigations, we have found that 13% of the female BB Wistar rats that spontaneously developed chemical diabetes had persistent estrous. In this study the ovaries of these rats were examined by scanning electron microscopy(SEM) and compared to normal-cycling controls as well as to rats that had developed polycystic ovaries(PCO) by exposure to constant 1ight.

Structural and functional renal alterations in five-sixth nephrectomized rats on unrestricted diet

1986 ◽  
Vol 44 ◽  
pp. 342-343
Author(s):  
I. Stachura ◽  
M. Pardo ◽  
J. Costello ◽  
D.M. Landwehr
Keyword(s):  
Wistar Rats ◽  
Renal Damage ◽  
Standard Diet ◽  
Experimental Conditions ◽  
Phosphate Intake ◽  
Dietary Restrictions ◽  
Severe Reduction ◽  
Male Wistar Rats ◽  
Unrestricted Diet ◽  
Progressive Renal Insufficiency

Under experimental conditions severe reduction of renal mass results in the hyperfiltration of the remaining nephrons leading to a progressive renal insufficiency. Similar changes are observed in patients with various renal disorders associated with a loss of the functioning nephrons. The progression of renal damage is accelerated by high protein and phosphate intake, and may be modified by the dietary restrictions.We studied 50 five-sixth nephrectarrized male Wistar rats on a standard diet (Rodent Laboratory Chow 5001 Ralston Purina Co., Richmond, Indiana; containing 23.4% protein) over a 20 week period.

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