Induction of TNF-α Production by Metal Complexes of γ-Globulin Fraction Proteins and Copper and Zinc Cations

2013 ◽  
Vol 154 (6) ◽  
pp. 758-761 ◽  
Author(s):  
S. B. Cheknev ◽  
I. E. Efremova ◽  
M. A. Apresova ◽  
A. A. Babajantz
Keyword(s):  
Metal Complexes ◽  
Globulin Fraction ◽  
Copper And Zinc ◽  
Tnf Α ◽  
Zinc Cations

Production of Late IFN-α Induced by Plasma γ-Globulin Fraction Proteins and Their Metal Complexes

2011 ◽  
Vol 150 (6) ◽  
pp. 722-724
Author(s):  
S. B. Cheknev ◽  
A. A. Babajanz ◽  
I. E. Efremova ◽  
L. S. Piskovskaya
Keyword(s):  
Metal Complexes ◽  
Globulin Fraction

scholarly journals Production of the Growth Factors GM-CSF, G-CSF, and VEGF by Human Peripheral Blood Cells Induced with Metal Complexes of Human Serumγ-Globulin Formed with Copper or Zinc Ions

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Sergey B. Cheknev ◽  
Maria A. Apresova ◽  
Nadezhda A. Moryakova ◽  
Irina E. Efremova ◽  
Anna S. Mezdrokhina ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Human Peripheral Blood ◽  
Theory And Practice ◽  
Basic Knowledge ◽  
Peripheral Blood Cells ◽  
Zinc Ions ◽  
Gm Csf ◽  
Copper And Zinc

As it was established in our previous studies, the proteins of human serumγ-globulin fraction could interact with copper or zinc ions distributed in the periglobular space, form metal complexes, and become able to perform effector functions differing due to the conformational shifts from those mediated by them in native conformation of their Fc regions. In the present work we have evaluated ability of theγ-globulin metal complexes formed with copper or zinc ions in the conditions like to the physiological ones to induce production or to regulate induction in the culture of freshly isolated human peripheral blood cells (PBC) of granulocyte (G) and granulocyte-macrophage (GM) colony-stimulating factors (CSF) as well as of vascular endothelial growth factor (VEGF). Theγ-globulin metal complexes formed with both copper and zinc ions were found to similarly reduce production of GM-CSF, G-CSF, and VEGF induced in normal human PBC cultures by the controlγ-globulins or by copper and zinc ions used alone. In context of theory and practice of inflammation the properties of theγ-globulin metal complexes might impact the basic knowledge in search of novel approaches to anti-inflammatory drugs development.

scholarly journals Metal-Based Biologically Active Compounds: Synthesis, Spectral, and Antimicrobial Studies of Cobalt, Nickel, Copper, and Zinc Complexes of Triazole-Derived Schiff Bases

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Kiran Singh ◽  
Yogender Kumar ◽  
Parvesh Puri ◽  
Chetan Sharma ◽  
Kamal Rai Aneja
Keyword(s):  
Metal Complexes ◽  
Schiff Bases ◽  
Antimicrobial Agents ◽  
Condensation Reaction ◽  
Zinc Complexes ◽  
Biologically Active ◽  
Planar Geometry ◽  
Cobalt Nickel ◽  
Copper And Zinc ◽  
Nickel Copper

A series of cobalt, nickel, copper, and zinc complexes of bidentate Schiff bases derived from the condensation reaction of 4-amino-5-mercapto-3-methyl/ethyl-1,2,4-triazole with 2,4-dichlorobenzaldehyde were synthesized and tested as antimicrobial agents. The synthesized Schiff bases and their metal complexes were characterized with the aid of elemental analyses, magnetic moment measurements, spectroscopic and thermogravimetric techniques. The presence of coordinated water in metal complexes was supported by infrared and thermal gravimetric studies. A square planar geometry was suggested for Cu(II) and octahedral geometry proposed for Co(II), Ni(II), and Zn(II) complexes. The Schiff bases and their metal complexes have been screened for antibacterial (Pseudomonas aeruginosa, Bacillus subtilis) and antifungal activities (Aspergillus niger, A. flavus). The metal complexes exhibited significantly enhanced antibacterial and antifungal activity as compared to their simple Schiff bases.

scholarly journals Thermal, Spectral, Fluorescence, and Antimicrobial Studies of Cobalt, Nickel, Copper, and Zinc Complexes Derived from 4-[(5-Bromo-thiophen-2-ylmethylene)-amino]-3-mercapto-6-methyl-5-oxo-[1,2,4]triazine

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Kiran Singh ◽  
Yogender Kumar ◽  
Parvesh Puri ◽  
Chetan Sharma ◽  
Kamal Rai Aneja
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Magnetic Measurements ◽  
Analytical Data ◽  
Fluorescence Emission ◽  
Zinc Complexes ◽  
Planar Geometry ◽  
Cobalt Nickel ◽  
Copper And Zinc ◽  
Nickel Copper

A new series of cobalt, nickel, copper, and zinc complexes of bidentate Schiff base derived from the condensation of 5-bromothiophene-2-carboxaldehyde with 4-amino-3-mercapto-6-methyl-5-oxo-[1,2,4]triazine were synthesized. Physical (magnetic measurements, molar conductance, TG), spectral (UV-Vis, IR, 1HNMR, fluorescence, ESR), and analytical data have established the structures of synthesized Schiff base and its metal complexes. The presence of coordinated water in metal complexes was confirmed by IR and TG studies. The Schiff base exhibits a strong fluorescence emission, contrast to this partial fluorescence quenching phenomena is observed in its metal complexes. A square planar geometry for Cu(II) and octahedral geometry for Co(II), Ni(II) and Zn(II) complexes have been proposed. The Schiff base and its metal complexes have been screened for antibacterial (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa) and antifungal activities (Aspergillus niger, A. flavus).

Four-coordinated see-sawN-(aryl)-2-(propan-2-ylidene)hydrazinecarbothioamide complexes of nickel(ii), copper(ii) and zinc(ii) and their propensity for catalytic cyclisation

2018 ◽  
Vol 47 (14) ◽  
pp. 4921-4930 ◽  
Author(s):  
Arup Tarai ◽  
Jubaraj B. Baruah
Keyword(s):  
Metal Complexes ◽  
Copper And Zinc ◽  
Nickel Copper ◽  
Divalent Nickel ◽  
Selective Reactivity

Four-coordinated metal complexes of two hydrazinecarbothioamide-derived ligands with divalent nickel, copper and zinc are described and the selective reactivity difference of copper(ii) to cyclise the ligand or to form a complex is described.

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