Role of Muscarinic M1, M2, and M3 Receptors in the Regulation of Electrical Activity of Myocardial Tissue of Caval Veins during the Early Postnatal Ontogeny

2019 ◽  
Vol 166 (4) ◽  
pp. 421-425
Author(s):  
A. D. Ivanova ◽  
S. V. Tapilina ◽  
V. S. Kuz’min
Keyword(s):  
Electrical Activity ◽  
Postnatal Ontogeny ◽  
Myocardial Tissue ◽  
M3 Receptors ◽  
Early Postnatal Ontogeny

Role of Neuropeptide Y in Myocardial Contractility of Rats during Early Postnatal Ontogeny

2014 ◽  
Vol 157 (4) ◽  
pp. 421-423 ◽  
Author(s):  
A. A. Zverev ◽  
T. A. Anikina ◽  
P. M. Maslyukov ◽  
T. L. Zefi rov
Keyword(s):  
Neuropeptide Y ◽  
Myocardial Contractility ◽  
Postnatal Ontogeny ◽  
Early Postnatal Ontogeny

scholarly journals The role of M3 receptors in regulation of electrical activity deteriorates in the rat heart during ageing

2021 ◽  
Author(s):  
Svetlana V. Tapilina ◽  
Alexandra D. Ivanova ◽  
Tatiana S. Filatova ◽  
Pavel A. Galenko-Yaroshevsky ◽  
Denis V. Abramochkin
Keyword(s):  
Electrical Activity ◽  
Rat Heart ◽  
M3 Receptors

The Role of Computer Modeling in Electrocardiography

1990 ◽  
Vol 29 (04) ◽  
pp. 282-288 ◽  
Author(s):  
A. van Oosterom
Keyword(s):  
Electrical Activity ◽  
Computer Modeling ◽  
Body Surface ◽  
Electrical Current ◽  
The Body ◽  
Volume Conductor ◽  
Current Generator ◽  
Cardiac Electrical Activity ◽  
Source Models

AbstractThis paper introduces some levels at which the computer has been incorporated in the research into the basis of electrocardiography. The emphasis lies on the modeling of the heart as an electrical current generator and of the properties of the body as a volume conductor, both playing a major role in the shaping of the electrocardiographic waveforms recorded at the body surface. It is claimed that the Forward-Problem of electrocardiography is no longer a problem. Several source models of cardiac electrical activity are considered, one of which can be directly interpreted in terms of the underlying electrophysiology (the depolarization sequence of the ventricles). The importance of using tailored rather than textbook geometry in inverse procedures is stressed.

Both M1 and M3 receptors regulate exocrine secretion by mucous acini

1996 ◽  
Vol 271 (6) ◽  
pp. C1963-C1972 ◽  
Author(s):  
D. J. Culp ◽  
W. Luo ◽  
L. A. Richardson ◽  
G. E. Watson ◽  
L. R. Latchney
Keyword(s):  
Inhibitory Effect ◽  
Exocrine Secretion ◽  
Muscarinic Agonist ◽  
High Affinity ◽  
Muscarinic Response ◽  
M1 Receptor ◽  
M3 Receptors ◽  
Pharmacological Studies ◽  
Equilibrium Dissociation

We investigated the role of M1 and M3 receptors in regulating exocrine secretion from acini isolated from rat sublingual glands. In secretion experiments, we derived affinity values (KB) from Schild regression analysis for the antagonists pirenzepine (61.0 nM) and 4-diphenylacetoxy-N-methylpiperidine (4-DAMP; 1.06 nM). The KB for 4-DAMP is similar to its affinity value [equilibrium dissociation constant from competition studies (Ki); 1.81 nM] determined from radioligand competition experiments. In contrast, the KB for pirenzepine is between its high-affinity (17.6 nM) and low-affinity (404 nM) Ki values. In separate secretion experiments, we found that the M1 receptor antagonist, M1-toxin, induces a rightward shift in the concentration-response curve to muscarinic agonist and inhibits maximal secretion by 40%. The inhibitory effect of M1-toxin appears specific for M1 receptor blockade, since the toxin abolishes acinar high-affinity pirenzepine-binding sites and does not inhibit secretion induced by nonmuscarinic agents. Additional pharmacological studies indicate muscarinic receptors do not function through putative neural elements within isolated acini. Our combined results are consistent with both M1 and M3 receptors directly regulating mucous acinar exocrine secretion and indicate M3 receptors alone are insufficient to induce a maximal muscarinic response.

The Role of Laser-Induced Fluorescence in Myocardial Tissue Characterization

CHEST Journal ◽  
2001 ◽  
Vol 120 (1) ◽  
pp. 233-239 ◽  
Author(s):  
George E. Kochiadakis ◽  
Stavros I. Chrysostomakis ◽  
Michael D. Kalebubas ◽  
George M. Filippidis ◽  
Ioannis G. Zacharakis ◽  
...  
Keyword(s):  
Tissue Characterization ◽  
Laser Induced Fluorescence ◽  
Myocardial Tissue ◽  
Myocardial Tissue Characterization

The decisive role of effective continuous chest compression for in-hospital resuscitation of pulseless electrical activity

Resuscitation ◽  
2008 ◽  
Vol 77 ◽  
pp. S7-S8
Author(s):  
H. Bonnemeier ◽  
Olivecrona ◽  
Simonis ◽  
Götberg ◽  
Weitz ◽  
...  
Keyword(s):  
Electrical Activity ◽  
Chest Compression ◽  
Pulseless Electrical Activity ◽  
Decisive Role

Pelvic aspiration in the American alligator (Alligator mississippiensis)

2000 ◽  
Vol 203 (11) ◽  
pp. 1679-1687 ◽  
Author(s):  
C.G. Farmer ◽  
D.R. Carrier
Keyword(s):  
Electrical Activity ◽  
Lung Ventilation ◽  
Rectus Abdominis ◽  
Transversus Abdominis ◽  
Alligator Mississippiensis ◽  
Abdominal Pressure ◽  
American Alligator ◽  
Diaphragmatic Breathing ◽  
Pelvic Muscles

The pelvis of crocodilians is highly derived in that the pubic bones are isolated from the acetabulum and are attached to the ischia via moveable joints. We examined the possible role of this unusual morphology in lung ventilation by measuring ventilation, abdominal pressure and the electrical activity of several abdominal and pelvic muscles in the American alligator (Alligator mississippiensis). We found that the activity of two pelvic muscles, the ischiopubis and ischiotruncus muscles, was correlated with inspiration; these muscles rotate the pubes ventrally and thereby increase abdominal volume. During expiration, contraction of the rectus abdominis and transversus abdominis rotates the pubes dorsally. We suggest that this mechanism facilitates diaphragmatic breathing by creating space for caudal displacement of the viscera during inspiration. Because birds also use a dorso-ventral movement of the pelvis to effect ventilation, some form of pelvic aspiration may be plesiomorphic for archosaurs.

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