Magnetic Resonance Imaging of Rat Brain in Assessment of the Neuroprotective Properties of Histochrome in Experimental Arterial Hypertension

2022 ◽  
Author(s):  
I. G. Agafonova ◽  
V. N. Kotel’nikov ◽  
B. I. Geltser
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Arterial Hypertension ◽  
Rat Brain ◽  
Resonance Imaging

scholarly journals How Stereological Analysis of Vascular Morphology Can Quantify the Blood Volume Fraction as a Marker for Tumor Vasculature: Comparison with Magnetic Resonance Imaging

2011 ◽  
Vol 32 (3) ◽  
pp. 489-501 ◽  
Author(s):  
Adriana T Perles-Barbacaru ◽  
Boudewijn PJ van der Sanden ◽  
Regine Farion ◽  
Hana Lahrech
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Rat Brain ◽  
Blood Volume ◽  
Volume Fraction ◽  
Three Dimensional ◽  
Simulated Data ◽  
Tumor Model ◽  
Tumor Vasculature ◽  
Resonance Imaging

To assess angiogenesis noninvasively in a C6 rat brain tumor model, the rapid-steady-state- T1 (RSST1) magnetic resonance imaging (MRI) method was used for microvascular blood volume fraction (BVf) quantification with a novel contrast agent gadolinium per (3,6 anhydro) α-cyclodextrin (Gd-ACX). In brain tissue contralateral to the tumor, equal BVfs were obtained with Gd-ACX and the clinically approved gadoterate meglumine (Gd-DOTA). Contrary to Gd-DOTA, which leaks out of the tumor vasculature, Gd-ACX was shown to remain vascular in the tumor tissue allowing quantification of the tumor BVf. We sought to confirm the obtained tumor BVf using an independent method: instead of using a ‘standard’ two-dimensional histologic method, we study here how vascular morphometry combined with a stereological technique can be used for three-dimensional assessment of the vascular volume fraction ( VV). The VV is calculated from the vascular diameter and length density. First, the technique is evaluated on simulated data and the healthy rat brain vasculature and is then applied to the same C6 tumor vasculature previously quantified by RSST1-MRI with Gd-ACX. The mean perfused VV and the BVf obtained by MRI in tumor regions are practically equal and the technique confirms the spatial heterogeneity revealed by MRI.

The Morpho-Functional Characteristics of Cerebral and Renal Arteries After Induced Arterial Hypertension in Rats Using Magnetic Resonance Imaging

2017 ◽  
Vol 48 (9) ◽  
pp. 911-919 ◽  
Author(s):  
Irina G. Agafonova ◽  
Vladimir N. Kotelnikov ◽  
Boris I. Geltcer ◽  
Natalya G. Kolosova ◽  
Valentin A. Stonik
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Arterial Hypertension ◽  
Renal Arteries ◽  
Resonance Imaging ◽  
Functional Characteristics

Examining the neural targets of the AMPA receptor potentiator LY404187 in the rat brain using pharmacological magnetic resonance imaging

2005 ◽  
Vol 180 (4) ◽  
pp. 743-751 ◽  
Author(s):  
Nicholas Jones ◽  
Michael J. O’Neill ◽  
Mark Tricklebank ◽  
Vincenzo Libri ◽  
Steve C. R. Williams
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Rat Brain ◽  
Ampa Receptor ◽  
Resonance Imaging
Sign in / Sign up

Export Citation Format

Share Document