eIF3b regulates the cell proliferation and apoptosis processes in chronic myelogenous leukemia cell lines via regulating the expression of C3G

2020 ◽  
Vol 42 (7) ◽  
pp. 1275-1286
Author(s):  
Laiquan Huang ◽  
Zhongling Wei ◽  
Xiangxiang Chang ◽  
Xinyuan Zheng ◽  
Jiawei Yan ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Chronic Myelogenous Leukemia ◽  
Leukemia Cell ◽  
Myelogenous Leukemia ◽  
Chronic Myelogenous Leukemia Cell ◽  
Leukemia Cell Lines ◽  
Proliferation And Apoptosis

Comparative Proteome Profiling and Functional Analysis of Chronic Myelogenous Leukemia Cell Lines

2007 ◽  
Vol 6 (11) ◽  
pp. 4330-4342 ◽  
Author(s):  
Simona Fontana ◽  
Riccardo Alessandro ◽  
Marilisa Barranca ◽  
Margherita Giordano ◽  
Chiara Corrado ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Cell Lines ◽  
Chronic Myelogenous Leukemia ◽  
Leukemia Cell ◽  
Myelogenous Leukemia ◽  
Chronic Myelogenous Leukemia Cell ◽  
Proteome Profiling ◽  
Leukemia Cell Lines

scholarly journals Ponatinib circumvents all types of imatinib resistance in chronic myelogenous leukemia cell lines

Cell Cycle ◽  
2013 ◽  
Vol 12 (11) ◽  
pp. 1645-1646 ◽  
Author(s):  
Ophelie Cassuto ◽  
Arnaud Jacquel ◽  
Guillaume Robert ◽  
Patrick Auberger
Keyword(s):  
Cell Lines ◽  
Chronic Myelogenous Leukemia ◽  
Leukemia Cell ◽  
Myelogenous Leukemia ◽  
Chronic Myelogenous Leukemia Cell ◽  
Imatinib Resistance ◽  
Leukemia Cell Lines

scholarly journals Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines

Blood ◽  
1992 ◽  
Vol 79 (9) ◽  
pp. 2215-2220 ◽  
Author(s):  
B Druker ◽  
K Okuda ◽  
U Matulonis ◽  
R Salgia ◽  
T Roberts ◽  
...  
Keyword(s):  
Cell Lines ◽  
Chronic Myelogenous Leukemia ◽  
Kinase Activity ◽  
Philadelphia Chromosome ◽  
Leukemia Cell ◽  
Myelogenous Leukemia ◽  
Hematopoietic Growth Factors ◽  
Chronic Myelogenous Leukemia Cell ◽  
Exon 2 ◽  
Associated Proteins

The Philadelphia chromosome (Ph1), detected in virtually all cases of chronic myelogenous leukemia, is formed by a reciprocal translocation between chromosomes 9 and 22 that fuses BCR encoded sequences upstream of exon 2 of c-ABL. This oncogene produces a fusion protein (p210BCR/ABL) in which the ABL tyrosine kinase activity is elevated. This elevated kinase activity is essential for transformation, but the mechanisms involved are unknown. We report here that p21ras GTPase activating protein (rasGAP) or rasGAP-associated proteins p190 and p62 are phosphorylated on tyrosine in Ph1 (+) cell lines. Further, rasGAP coimmunoprecipitates with p210BCR/ABL in these cell lines. These results suggest that rasGAP or associated proteins are potential substrates for p210BCR/ABL kinase and thus directly link p210BCR/ABL with a signal transduction pathway known to be activated by hematopoietic growth factors (p21ras).

scholarly journals Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines

Blood ◽  
1992 ◽  
Vol 79 (9) ◽  
pp. 2215-2220 ◽  
Author(s):  
B Druker ◽  
K Okuda ◽  
U Matulonis ◽  
R Salgia ◽  
T Roberts ◽  
...  
Keyword(s):  
Cell Lines ◽  
Chronic Myelogenous Leukemia ◽  
Kinase Activity ◽  
Philadelphia Chromosome ◽  
Leukemia Cell ◽  
Myelogenous Leukemia ◽  
Hematopoietic Growth Factors ◽  
Chronic Myelogenous Leukemia Cell ◽  
Exon 2 ◽  
Associated Proteins

Abstract The Philadelphia chromosome (Ph1), detected in virtually all cases of chronic myelogenous leukemia, is formed by a reciprocal translocation between chromosomes 9 and 22 that fuses BCR encoded sequences upstream of exon 2 of c-ABL. This oncogene produces a fusion protein (p210BCR/ABL) in which the ABL tyrosine kinase activity is elevated. This elevated kinase activity is essential for transformation, but the mechanisms involved are unknown. We report here that p21ras GTPase activating protein (rasGAP) or rasGAP-associated proteins p190 and p62 are phosphorylated on tyrosine in Ph1 (+) cell lines. Further, rasGAP coimmunoprecipitates with p210BCR/ABL in these cell lines. These results suggest that rasGAP or associated proteins are potential substrates for p210BCR/ABL kinase and thus directly link p210BCR/ABL with a signal transduction pathway known to be activated by hematopoietic growth factors (p21ras).

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