Drug release evaluation of Paclitaxel/Poly-L-Lactic acid nanoparticles based on a microfluidic chip

2021 ◽  
Vol 23 (4) ◽  
Author(s):  
Xiang Zhang ◽  
Guotao Guan ◽  
Zhenxing Wang ◽  
Li Lv ◽  
Carolina Chávez-Madero ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Microfluidic Chip

scholarly journals Drug Release from Electrospun Poly(Lactic Acid) Membranes and Their Cell Viability in Vitro Test

2012 ◽  
Vol 44 ◽  
pp. 866-868 ◽  
Author(s):  
A.P.S. Immich ◽  
M. Lis ◽  
L.H. Catalani ◽  
R.L. Boemo ◽  
J.A. Tornero
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Cell Viability ◽  
Poly Lactic Acid ◽  
In Vitro Test ◽  
Vitro Test

Porous poly(l-lactic acid) nanocomposite scaffolds with functionalized TiO2 nanoparticles: properties, cytocompatibility and drug release capability

2018 ◽  
Vol 53 (16) ◽  
pp. 11151-11166 ◽  
Author(s):  
Aleksandra Buzarovska ◽  
Sorina Dinescu ◽  
Leona Chitoiu ◽  
Marieta Costache
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Tio2 Nanoparticles ◽  
Nanocomposite Scaffolds ◽  
Porous Poly

scholarly journals Preparation and Drug-Release Kinetics of Porous Poly(L-lactic acid)/Rifampicin Blend Particles

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Takashi Sasaki ◽  
Hiroaki Matsuura ◽  
Kazuki Tanaka
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Solution Concentration ◽  
Porous Polymer ◽  
High Porosity ◽  
Original Solution ◽  
Kinetics Of

Porous polymer spheres are promising materials as carriers for controlled drug release. As a new drug-carrier material, blend particles composed of poly(L-lactic acid) (PLLA) and rifampicin were developed using the freeze-drying technique. The blend particles exhibit high porosity with a specific surface area of 10–40 m2 g−1. Both the size and porosity of the particles depend on the concentration of the original solution and on the method of freezing. With respect to the latter, we used the drop method (pouring the original solution dropwise into liquid nitrogen) and the spray method (freezing a mist of the original solution). The release kinetics of rifampicin from the blend particles into water depends significantly on the morphology of the blend particles. The results show that the release rate can be controlled to a great extent by tuning the size and porosity of the blend particles, both of which are varied by parameters such as the solution concentration and the method of freezing.

Synthesis and Kinetic Studies on Controlled Release of 6-Thioguanine Entrapped Polyethylene Glycol-Co-Polylactic Acid Polymer Nanoparticles

2011 ◽  
Vol 9 (1) ◽  
Author(s):  
Sathishkumar Kannaiyan ◽  
T.G.Ashwin Narayanan ◽  
P.Karthick Sarathy ◽  
Nagarjun Sudhakar ◽  
Rama Krishnan
Keyword(s):  
Gold Nanoparticles ◽  
Lactic Acid ◽  
Polyethylene Glycol ◽  
Controlled Release ◽  
Drug Release ◽  
Kinetic Equations ◽  
Kinetic Studies ◽  
Poly Lactic Acid ◽  
Average Size

Poly lactic acid-polyethylene glycol (PLA-co-PEG) copolyester was synthesized from oligomer of L-lactic acid and poly ethylene glycol (PEG) using stannous octoate as catalyst. 6-Thioguanine containing Poly lactic acid-polyethylene glycol (PLA-co-PEG) nanocapsules were prepared in the presence and absence of gold nanoparticles via the W/O/W emulsification solvent-evaporation method. The morphologies of prepared nanocapsules changed substantially because of the presence of gold nanoparticles. From SEM and TEM measurements, the average size of the polymer nanocapsules and gold nanoparticles were found to be in range of 230-260 nm and 18-20 nm, respectively. In general the drug release was quicker in Phosphate buffer saline (pH 7.4) compared to 0.1M hydrochloric acid and this may be due to higher solubility, higher swelling and penetration properties of PLA-co-PEG in PBS compared to HCl. Polymer nanocapsules with gold show a prolonged controlled release with higher encapsulation efficiency (75%) compared to that of polymer nanocapsules (45%) in the absence of gold nanoparticles. It may be due to the more entrapping efficiency of gold and less diffusivity of drugs from the nanocapsules. Application of in vitro drug release data to various kinetic equations indicated Higuchi model, indicating a uniform distribution of thioguanine in the nanocapsules.

Evaluation of in Vitro Drug Release, pH Change, and Molecular Weight Degradation of Poly(L-lactic acid) and Poly(D,L-lactide-co-glycolide) Fibers

2005 ◽  
Vol 11 (7-8) ◽  
pp. 1077-1084 ◽  
Author(s):  
B.B. Crow ◽  
A.F. Borneman ◽  
D.L. Hawkins ◽  
G.M. Smith ◽  
K.D. Nelson
Keyword(s):  
Molecular Weight ◽  
Lactic Acid ◽  
Drug Release ◽  
Ph Change ◽  
In Vitro Drug Release

Dextrin crosslinked with poly(lactic acid): A novel hydrogel for controlled drug release application

2013 ◽  
Vol 131 (7) ◽  
pp. n/a-n/a ◽  
Author(s):  
Dipankar Das ◽  
Raghunath Das ◽  
Jayanta Mandal ◽  
Animesh Ghosh ◽  
Sagar Pal
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Poly Lactic Acid

5-Fluorouracil monodispersed chitosan microspheres: Microfluidic chip fabrication with crosslinking, characterization, drug release and anticancer activity

2020 ◽  
Vol 236 ◽  
pp. 116094 ◽  
Author(s):  
Tianxi He ◽  
Wenbin Wang ◽  
Benshou Chen ◽  
Jiu Wang ◽  
Qionglin Liang ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Activity ◽  
Microfluidic Chip ◽  
Chitosan Microspheres ◽  
Chip Fabrication
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