Drug release evaluation of Paclitaxel/Poly-L-Lactic acid nanoparticles based on a microfluidic chip

Porous polymer spheres are promising materials as carriers for controlled drug release. As a new drug-carrier material, blend particles composed of poly(L-lactic acid) (PLLA) and rifampicin were developed using the freeze-drying technique. The blend particles exhibit high porosity with a specific surface area of 10–40 m2 g−1. Both the size and porosity of the particles depend on the concentration of the original solution and on the method of freezing. With respect to the latter, we used the drop method (pouring the original solution dropwise into liquid nitrogen) and the spray method (freezing a mist of the original solution). The release kinetics of rifampicin from the blend particles into water depends significantly on the morphology of the blend particles. The results show that the release rate can be controlled to a great extent by tuning the size and porosity of the blend particles, both of which are varied by parameters such as the solution concentration and the method of freezing.

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Mineralization and drug release of hydroxyapatite/poly( l -lactic acid) nanocomposite scaffolds prepared by Pickering emulsion templating

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2014.07.032 ◽

2014 ◽

Vol 122 ◽

pp. 559-565 ◽

Cited By ~ 41

Author(s):

Yang Hu ◽

Shengwen Zou ◽

Weike Chen ◽

Zhen Tong ◽

Chaoyang Wang

Keyword(s):

Lactic Acid ◽

Drug Release ◽

Pickering Emulsion ◽

Nanocomposite Scaffolds ◽

Emulsion Templating

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Preparation and Performance of Poly(D,L-lactic acid)–Polyethylene Glycol–Poly(D,L-lactic acid) Electrospun Fibrous Membranes for Drug Release

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2017.12717 ◽

2017 ◽

Vol 17 (2) ◽

pp. 884-892

Author(s):

Dong Jiang ◽

Henan Zhan ◽

Xiyu Hu ◽

Jiashuang Luan ◽

Mei Zhang

Keyword(s):

Lactic Acid ◽

Polyethylene Glycol ◽

Drug Release ◽

Fibrous Membranes ◽

And Performance

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Preparation and Drug Release of All-Trans Retinoic Acid-Loaded Poly(L-lactic acid) Nanoparticles

Journal of Korean Pharmaceutical Sciences ◽

10.4333/kps.2004.34.5.401 ◽

2004 ◽

Vol 34 (5) ◽

pp. 401-406

Keyword(s):

Lactic Acid ◽

Retinoic Acid ◽

Drug Release ◽

Trans Retinoic Acid ◽

All Trans Retinoic Acid

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Synthesis and Kinetic Studies on Controlled Release of 6-Thioguanine Entrapped Polyethylene Glycol-Co-Polylactic Acid Polymer Nanoparticles

International Journal of Chemical Reactor Engineering ◽

10.2202/1542-6580.2766 ◽

2011 ◽

Vol 9 (1) ◽

Author(s):

Sathishkumar Kannaiyan ◽

T.G.Ashwin Narayanan ◽

P.Karthick Sarathy ◽

Nagarjun Sudhakar ◽

Rama Krishnan

Keyword(s):

Gold Nanoparticles ◽

Lactic Acid ◽

Polyethylene Glycol ◽

Controlled Release ◽

Drug Release ◽

Kinetic Equations ◽

Kinetic Studies ◽

Poly Lactic Acid ◽

Average Size

Poly lactic acid-polyethylene glycol (PLA-co-PEG) copolyester was synthesized from oligomer of L-lactic acid and poly ethylene glycol (PEG) using stannous octoate as catalyst. 6-Thioguanine containing Poly lactic acid-polyethylene glycol (PLA-co-PEG) nanocapsules were prepared in the presence and absence of gold nanoparticles via the W/O/W emulsification solvent-evaporation method. The morphologies of prepared nanocapsules changed substantially because of the presence of gold nanoparticles. From SEM and TEM measurements, the average size of the polymer nanocapsules and gold nanoparticles were found to be in range of 230-260 nm and 18-20 nm, respectively. In general the drug release was quicker in Phosphate buffer saline (pH 7.4) compared to 0.1M hydrochloric acid and this may be due to higher solubility, higher swelling and penetration properties of PLA-co-PEG in PBS compared to HCl. Polymer nanocapsules with gold show a prolonged controlled release with higher encapsulation efficiency (75%) compared to that of polymer nanocapsules (45%) in the absence of gold nanoparticles. It may be due to the more entrapping efficiency of gold and less diffusivity of drugs from the nanocapsules. Application of in vitro drug release data to various kinetic equations indicated Higuchi model, indicating a uniform distribution of thioguanine in the nanocapsules.

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