Prospective study of electrical impedance scanning for identifying young women at risk for breast cancer

2006 ◽  
Vol 97 (2) ◽  
pp. 179-189 ◽  
Author(s):  
Alexander Stojadinovic ◽  
Orah Moskovitz ◽  
Zahava Gallimidi ◽  
Scott Fields ◽  
Ari D. Brooks ◽  
...  
2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 692-692
Author(s):  
A. Stojadinovic ◽  
O. Moskovitz ◽  
Z. Gallimidi ◽  
S. Fields ◽  
A. D. Brooks ◽  
...  

2009 ◽  
Vol 28 (3) ◽  
pp. 295-303 ◽  
Author(s):  
Ting Wang ◽  
Kan Wang ◽  
Qing Yao ◽  
Jiang-hao Chen ◽  
Rui Ling ◽  
...  

2008 ◽  
Vol 97 (2) ◽  
pp. 112-120 ◽  
Author(s):  
Alexander Stojadinovic ◽  
Aviram Nissan ◽  
Craig D. Shriver ◽  
Elizabeth A. Mittendorf ◽  
Mark D. Akin ◽  
...  

2005 ◽  
Vol 23 (12) ◽  
pp. 2703-2715 ◽  
Author(s):  
Alexander Stojadinovic ◽  
Aviram Nissan ◽  
Zahava Gallimidi ◽  
Sarah Lenington ◽  
Wende Logan ◽  
...  

Purpose To evaluate the feasibility and patient satisfaction with electrical impedance scanning (EIS) for early detection of breast cancer in young women. Methods Women undergoing screening clinical breast examination, imaging, or biopsy were eligible for EIS examination with T-Scan 2000ED (Mirabel Medical Systems, Austin, TX). Multiple logistic regression analysis evaluated the association between clinical variables and EIS performance. Patients completed a screening EIS satisfaction questionnaire (1 = least satisfied to 5 = most satisfied). Results Twenty-nine cancers were identified among 1,103 women. Sixty-six percent (19 of 29) of cancers were nonpalpable and 55% (16 of 29) were in women age ≤ 50 years. EIS sensitivity and specificity in women younger than 40 years was 50% and 90%, respectively. Exogenous estrogen use (P < .001) and menopausal status (P = .007) correlated significantly with EIS performance. False-positive rates were increased in postmenopausal women and those taking exogenous hormones. No correlation was evident between EIS performance and family history, prior breast cancer, breast density, or palpability. EIS-positive women younger than age 40 were 4.5 times more likely to have breast carcinoma than were women randomly selected from the general population. Patients were highly satisfied with the comfort, speed, and reporting of EIS screening (mean score, 4.8). Conclusion EIS seems promising for early detection of breast cancer, and identification of young women at increased risk for having the disease at time of screening. Positive EIS-associated breast cancer risk compares favorably with relative risks of conditions commonly used to justify early breast cancer screening. Patients are satisfied with a screening paradigm involving breast EIS.


2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e24057-e24057
Author(s):  
Angelena Crown ◽  
Nadia Abdo ◽  
Ariela Noy ◽  
Cassandra Chang ◽  
Mary Gemignani ◽  
...  

e24057 Background: The American Society of Clinical Oncology guidelines recommend discussing the possibility of infertility in cancer patients of childbearing age being treated with gonadotoxic therapies. This prospective study examines the reproductive history and future family building preferences of young women with breast cancer. Methods: This is an Institutional Review Board approved prospective study of women < 45 years of age with non-metastatic invasive breast cancer who completed a questionnaire on reproductive history and family building preferences between April 2013 and December 2019. Questionnaires were administered at initial diagnosis and then annually. Results: Baseline questionnaires were completed by 164 women with a median age of 39 years old (range 20-45); 110 (59%) completed the 1 year follow up survey. Clinicopathologic features and treatment are shown in the table. The majority of women (n = 90, 55%) were parous and many had previous infertility (n = 60, 37%) at time of diagnosis. Most women (n = 87, 53%) wanted additional children or were unsure. Interest in embryo and/or oocyte cryopreservation was common (n = 51, 31%) as was interest in adoption (n = 52, 32%). Of the 110 women who completed the one year follow-up, 39 (35%) saw a reproductive endocrinologist, including 22 (20%) who elected embryo (n = 14) or oocyte (n = 8) cryopreservation. Overall, 88 (80%) women declined fertility preservation. The most common reasons included worrying about delay in cancer treatment (n = 10, 9%), fear of hormonal exposure (n = 7, 6%), and feeling rushed into making a decision (n = 6, 6%). Of 92 women with available data regarding satisfaction with their decision to pursue fertility preservation or not, 84% (n = 77) reported satisfaction whereas 14% (n = 15) reported mixed feelings or regret. Conclusions: Young women with breast cancer expressed a significant interest in family building options. However, pursuit of fertility preservation was uncommon despite a high rate of prior infertility in this cohort of mostly parous women. Decisional satisfaction was common. Further study of factors contributing to patient decision-making regarding fertility preservation and alternative family building options is warranted. Clinical trial information: NCT01788839 . [Table: see text]


2010 ◽  
Vol 19 (10) ◽  
pp. 2496-2502 ◽  
Author(s):  
David J. Hunter ◽  
Graham A. Colditz ◽  
Susan E. Hankinson ◽  
Susan Malspeis ◽  
Donna Spiegelman ◽  
...  

2017 ◽  
Vol 17 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Rachael Glassey ◽  
◽  
Moira O’Connor ◽  
Angela Ives ◽  
Christobel Saunders ◽  
...  

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