MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls

2010 ◽  
Vol 123 (2) ◽  
pp. 549-555 ◽  
Author(s):  
Jian Zhang ◽  
Li-Xin Qiu ◽  
Zhong-Hua Wang ◽  
Xiang-Hua Wu ◽  
Xiao-Jian Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
Breast Cancer Susceptibility ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism

scholarly journals Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis

2017 ◽  
Vol 37 (6) ◽  
Author(s):  
Lingyan Xu ◽  
Zhiqiang Qin ◽  
Feng Wang ◽  
Shuhui Si ◽  
Lele Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Publication Bias ◽  
Methylenetetrahydrofolate Reductase ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
Control Group ◽  
C677t Polymorphism ◽  
Case Control Studies ◽  
Mthfr C677t Polymorphism

The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer (CRC) susceptibility has been researched in numerous studies. However, the results of these studies were controversial. Therefore, the objective of this meta-analysis was to offer a more convincible conclusion about such association with more included studies. Eligible studies published till May 1, 2017 were searched from PubMed, Embase, Web of Science, and CNKI database about such association. Pooled odds ratios (ORs) together with 95% confidence intervals (CIs) were calculated to evaluate such association. And the Begg’s funnel plot and Egger’s test were applied to assess the publication bias. This meta-analysis contained 37049 cases and 52444 controls from 87 publications with 91 eligible case–control studies. Because of lack of data for a particular genotype in several studies, all the included studies were analysed barely in the dominant model. Originally, there was no association between MTHFR C677T polymorphism and CRC susceptibility (OR =0.99, 95% CI =0.94–1.05). After excluding 13 studies according to their heterogeneity and publication bias, rs1801133 polymorphism was found to reduce the risks of CRC significantly (OR =0.96, 95% CI =0.94–0.99). In the subgroup analysis of ethnicity, there was a significant association in Asians (OR =0.94, 95% CI =0.89–1.00). Furthermore, when stratified by the source of controls and genotyping methods, the positive results were observed in population-based control group (OR =0.97, 95% CI =0.93–1.00) and PCR-restriction fragment length polymorphism (PCR-RFLP) method (OR =0.95, 95% CI =0.91–0.99. The results of the meta-analysis suggested that MTHFR C677T polymorphism was associated with CRC susceptibility, especially in Asian population.

scholarly journals MTHFR C677T polymorphism and osteoporotic fracture in postmenopausal women: a meta-analysis

2014 ◽  
Vol 13 (3) ◽  
pp. 7356-7364 ◽  
Author(s):  
J.Z. Guan ◽  
M. Wu ◽  
Y.Z. Xiao ◽  
J.S. Zhou ◽  
Z.D. Wang
Keyword(s):  
Postmenopausal Women ◽  
Osteoporotic Fracture ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism

XRCC3 5′-UTR and IVS5-14 polymorphisms and breast cancer susceptibility: a meta-analysis

2010 ◽  
Vol 122 (2) ◽  
pp. 489-493 ◽  
Author(s):  
Li-Xin Qiu ◽  
Chen Mao ◽  
Lei Yao ◽  
Ke-Da Yu ◽  
Ping Zhan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Breast Cancer Susceptibility

Decrease in gastric cancer susceptibility by MTHFR C677T polymorphism in Ardabil Province, Iran

2013 ◽  
Vol 24 (2) ◽  
pp. 117-121 ◽  
Author(s):  
S Saied HOSSEINI-ASL ◽  
Farhad POURFARZI ◽  
Abazar BARZEGAR ◽  
Mohammad MAZANI ◽  
Nima FARAHMAND ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Susceptibility ◽  
Mthfr C677t ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism
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