Economic issues involved in integrating genomic testing into clinical care: the case of genomic testing to guide decision-making about chemotherapy for breast cancer patients

BACKGROUND: Cancer is a disease caused by abnormal growth of body cells that turn malignant and continue to grow uncontrollably. One of the treatments for breast cancer is mastectomy. The quickness of decision-making determines the survival rate of prognosis patients. OBJECTIVE: This study aimed to determine the relationship of self-acceptance with decision-making duration in cancer patients to perform a mastectomy. METHODS: An analytic observation method with cross-sectional design. The samples were taken by purposive sampling method with 50 samples of breast cancer patients. Data collected include age, last level of education, marital status, profession, stage of cancer during mastectomy, self-acceptance score, and decision-making duration to perform a mastectomy. RESULTS: The data analyzed with the Kruskal–Wallis test. The test showed the relationship of self-acceptance (p = 0.027) with decision-making duration in breast cancer patients to perform a mastectomy. CONCLUSION: In Conclusion, there is a relationship of self-acceptance with decision-making duration in breast cancer patients to perform a mastectomy.

Download Full-text

Next-generation sequencing of BRCA1/2 in breast cancer patients: potential effects on clinical decision-making using rapid, high-accuracy genetic results

Annals of Surgical Treatment and Research ◽

10.4174/astr.2017.92.5.331 ◽

2017 ◽

Vol 92 (5) ◽

pp. 331 ◽

Cited By ~ 5

Author(s):

Hyung Seok Park ◽

Seo-Jin Park ◽

Jee Ye Kim ◽

Sanghwa Kim ◽

Jaegyu Ryu ◽

...

Keyword(s):

Breast Cancer ◽

Decision Making ◽

Next Generation Sequencing ◽

Cancer Patients ◽

Clinical Decision Making ◽

Clinical Decision ◽

High Accuracy ◽

Breast Cancer Patients ◽

Generation Sequencing ◽

Genetic Results

Download Full-text

Shared decision-making for breast cancer patients

Early Breast Cancer ◽

10.1201/b13937-32 ◽

2013 ◽

pp. 311-321

Author(s):

Catharine Clay ◽

Alice Andrews ◽

Dale Vidal

Keyword(s):

Breast Cancer ◽

Decision Making ◽

Cancer Patients ◽

Shared Decision Making ◽

Shared Decision ◽

Breast Cancer Patients

Download Full-text

Breast cancer patients' personality style, age, and treatment decision making

Journal of Surgical Oncology ◽

10.1002/(sici)1096-9098(199611)63:3<183::aid-jso9>3.0.co;2-9 ◽

1996 ◽

Vol 63 (3) ◽

pp. 183-186 ◽

Cited By ~ 33

Author(s):

Julie D. Johnson ◽

Cleora S. Roberts ◽

Charles E. Cox ◽

Douglas S. Reintgen ◽

Judi S. Levine ◽

...

Keyword(s):

Breast Cancer ◽

Decision Making ◽

Cancer Patients ◽

Treatment Decision ◽

Breast Cancer Patients ◽

Personality Style ◽

Treatment Decision Making

Download Full-text

Breast Cancer Patients' Views on the Use of Genomic Testing to Guide Decisions about Their Postoperative Chemotherapy

Public Health Genomics ◽

10.1159/000349920 ◽

2013 ◽

Vol 16 (3) ◽

pp. 110-117 ◽

Cited By ~ 4

Author(s):

V. Seror ◽

P. Marino ◽

F. Bertucci ◽

J. Mancini ◽

J.-M. Extra ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Postoperative Chemotherapy ◽

Genomic Testing ◽

Breast Cancer Patients

Download Full-text

Abstract PS15-18: Clinical utility of genomic testing for early stage breast cancer patients treated with APBI brachytherapy

10.1158/1538-7445.sabcs20-ps15-18 ◽

2021 ◽

Author(s):

Roberto Diaz ◽

Matthew N Mills ◽

Ronica H Nanda ◽

Lisa L Stout ◽

Scott Dube ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Clinical Utility ◽

Early Stage ◽

Early Stage Breast Cancer ◽

Genomic Testing ◽

Breast Cancer Patients

Download Full-text

Weight Loss in Breast Cancer Patient Management

Journal of Clinical Oncology ◽

10.1200/jco.2002.20.4.1128 ◽

2002 ◽

Vol 20 (4) ◽

pp. 1128-1143 ◽

Cited By ~ 205

Author(s):

Rowan T. Chlebowski ◽

Erin Aiello ◽

Anne McTiernan

Keyword(s):

Breast Cancer ◽

Weight Loss ◽

Clinical Outcome ◽

Cancer Patients ◽

Clinical Care ◽

Current Status ◽

Current Evidence ◽

Dietary Therapy ◽

Breast Cancer Patients ◽

Breast Cancer Outcome

PURPOSE: To systematically review and summarize evidence relevant to obesity and breast cancer clinical outcome, potential hormonal mediating mechanisms, and the current status of weight loss interventions for chronic disease management. METHODS: A comprehensive, formal literature review was conducted to identify 5,687 citations with key information from 159 references summarized in text and tables. This process included a search for all breast cancer studies exploring associations among survival or recurrence and obesity at diagnosis or weight gain after diagnosis using prospective criteria. RESULTS: On the basis of observational studies, women with breast cancer who are overweight or gain weight after diagnosis are found to be at greater risk for breast cancer recurrence and death compared with lighter women. Obesity is also associated with hormonal profiles likely to stimulate breast cancer growth. Recently, use of weight loss algorithms proven successful in other clinical settings that incorporate dietary therapy, physical activity, and ongoing behavior therapy have been endorsed by the National Institutes of Health and other health agencies. CONCLUSION: Although definitive weight loss intervention trials in breast cancer patients remain to be conducted, the current evidence relating increased body weight to adverse breast cancer outcome and the documented favorable effects of weight loss on clinical outcome in other comorbid conditions support consideration of programs for weight loss in breast cancer patients. Recommendations for the clinical care of overweight or obese breast cancer patients are offered.

Download Full-text

Biopsychosocial and clinical characteristics in patients with resected breast and colon cancer at the beginning and end of adjuvant treatment

BMC Cancer ◽

10.1186/s12885-019-6358-x ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Teresa García-García ◽

Alberto Carmona-Bayonas ◽

Paula Jimenez-Fonseca ◽

Carlos Jara ◽

Carmen Beato ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Decision Making ◽

Colon Cancer ◽

Cancer Patients ◽

Adjuvant Treatment ◽

Perceived Social Support ◽

Shared Decision ◽

Breast Cancer Patients

Abstract Background The aim of this study was to analyze biopsychosocial factors affecting how patients cope with cancer and adjuvant treatment and to appraise psychological distress, coping, perceived social support, quality of life and SDM before and after adjuvant treatment in breast cancer patients compared to colon cancer patients. Methods NEOcoping is a national, multicenter, cross-sectional, prospective study. The sample comprised 266 patients with colon cancer and 231 with breast cancer. The instruments used were the Brief Symptom Inventory (BSI), Mini-Mental Adjustment to Cancer (Mini-MAC), Multidimensional Scale of Perceived Social Support (MSPSS), Shared Decision-Making Questionnaire-Patient (SDM-Q-9) and Physician’s (SDM-Q-Doc), and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ). Results Breast cancer patients reacted worse to the diagnosis of cancer with more symptoms of anxiety, depression, and somatization, and were less satisfied with their involvement than those with colon cancer (p = 0.003). Participants with colon cancer were older and had more physical symptoms and functional limitations at the beginning of adjuvant treatment, while there were scarcely any differences between the two groups at the end of adjuvancy, at which time both groups suffered greater psychological and physical effects and scored lower on coping strategies, except for anxious preoccupation. Conclusions Breast cancer patients need more information and involvement of the oncologist in shared decision-making, as well as and more medical and psychological support when beginning adjuvant treatment. Both breast and colon cancer patients may require additional psychological care at the end of adjuvancy.

Download Full-text