The Estrogen Receptor α Gene and Breast Cancer Risk (The Netherlands)

2005 ◽  
Vol 16 (10) ◽  
pp. 1195-1202 ◽  
Author(s):  
N. Charlotte Onland-Moret ◽  
Carla H. van Gils ◽  
Mark Roest ◽  
Diederick E. Grobbee ◽  
Petra H. M. Peeters
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
The Netherlands ◽  
Estrogen Receptor Α ◽  
Estrogen Receptor Α Gene

scholarly journals Estrogen receptor α polymorphisms and postmenopausal breast cancer risk

2007 ◽  
Vol 107 (3) ◽  
pp. 415-419 ◽  
Author(s):  
A. M. González-Zuloeta Ladd ◽  
A. Arias Vásquez ◽  
F. Rivadeneira ◽  
C. Siemes ◽  
A. Hofman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Postmenopausal Breast Cancer ◽  
Estrogen Receptor Α ◽  
Postmenopausal Breast Cancer Risk

scholarly journals Association of estrogen receptor α polymorphisms with breast cancer risk in older Caucasian women

2005 ◽  
Vol 116 (6) ◽  
pp. 984-991 ◽  
Author(s):  
Francesmary Modugno ◽  
Joseph M. Zmuda ◽  
Douglas Potter ◽  
Chao Cai ◽  
Elad Ziv ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Estrogen Receptor Α ◽  
Caucasian Women

scholarly journals Breast Cancer Risk in Usual Ductal Hyperplasia Is Defined by Estrogen Receptor-α and Ki-67 Expression

2002 ◽  
Vol 160 (2) ◽  
pp. 597-604 ◽  
Author(s):  
Abeer M. Shaaban ◽  
John P. Sloane ◽  
Christopher R. West ◽  
Christopher S. Foster
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Estrogen Receptor Α ◽  
Ki 67 ◽  
Usual Ductal Hyperplasia ◽  
Ductal Hyperplasia

scholarly journals Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis

2018 ◽  
Vol 48 (3) ◽  
pp. 795-806 ◽  
Author(s):  
Xiang Shu ◽  
Lang Wu ◽  
Nikhil K Khankari ◽  
Xiao-Ou Shu ◽  
Thomas J Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Type 2 Diabetes ◽  
Estrogen Receptor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Mendelian Randomization ◽  
Menopausal Status ◽  
Inverse Association ◽  
Fasting Insulin

Abstract Background In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear. Methods We conducted Mendelian randomization analyses to evaluate the association of breast cancer risk, using genetic instruments, with fasting insulin, fasting glucose, 2-h glucose, body mass index (BMI) and BMI-adjusted waist-hip-ratio (WHRadj BMI). We first confirmed the association of these instruments with type 2 diabetes risk in a large diabetes genome-wide association study consortium. We then investigated their associations with breast cancer risk using individual-level data obtained from 98 842 cases and 83 464 controls of European descent in the Breast Cancer Association Consortium. Results All sets of instruments were associated with risk of type 2 diabetes. Associations with breast cancer risk were found for genetically predicted fasting insulin [odds ratio (OR) = 1.71 per standard deviation (SD) increase, 95% confidence interval (CI) = 1.26-2.31, p  =  5.09  ×  10–4], 2-h glucose (OR = 1.80 per SD increase, 95% CI = 1.3 0-2.49, p  =  4.02  ×  10–4), BMI (OR = 0.70 per 5-unit increase, 95% CI = 0.65-0.76, p  =  5.05  ×  10–19) and WHRadj BMI (OR = 0.85, 95% CI = 0.79-0.91, p  =  9.22  ×  10–6). Stratified analyses showed that genetically predicted fasting insulin was more closely related to risk of estrogen-receptor [ER]-positive cancer, whereas the associations with instruments of 2-h glucose, BMI and WHRadj BMI were consistent regardless of age, menopausal status, estrogen receptor status and family history of breast cancer. Conclusions We confirmed the previously reported inverse association of genetically predicted BMI with breast cancer risk, and showed a positive association of genetically predicted fasting insulin and 2-h glucose and an inverse association of WHRadj BMI with breast cancer risk. Our study suggests that genetically determined obesity and glucose/insulin-related traits have an important role in the aetiology of breast cancer.

scholarly journals Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Yiwey Shieh ◽  
Christopher G. Scott ◽  
Matthew R. Jensen ◽  
Aaron D. Norman ◽  
Kimberly A. Bertrand ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Estrogen Receptor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Body Mass ◽  
Mammographic Density ◽  
Receptor Subtype

Does the Decrease in Hormone Replacement Therapy Also Affect Breast Cancer Risk in the Netherlands?

2007 ◽  
Vol 25 (31) ◽  
pp. 5038-5039 ◽  
Author(s):  
Isabelle Soerjomataram ◽  
Jan Willem Coebergh ◽  
Marieke W.J. Louwman ◽  
Otto Visser ◽  
Flora E. van Leeuwen
Keyword(s):  
Breast Cancer ◽  
Hormone Replacement Therapy ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
The Netherlands ◽  
Replacement Therapy ◽  
Hormone Replacement
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