scholarly journals Influence of birth weight and adult body composition on 17β-estradiol levels in young women

2008 ◽  
Vol 20 (2) ◽  
pp. 233-242 ◽  
Author(s):  
Sissi Espetvedt Finstad ◽  
Aina Emaus ◽  
Nancy Potischman ◽  
Emily Barrett ◽  
Anne-Sofie Furberg ◽  
...  
2002 ◽  
Vol 75 (4) ◽  
pp. 676-682 ◽  
Author(s):  
Ruth JF Loos ◽  
Gaston Beunen ◽  
Robert Fagard ◽  
Catherine Derom ◽  
Robert Vlietinck

2003 ◽  
Vol 11 (2) ◽  
pp. 202-208 ◽  
Author(s):  
Saskia J. te Velde ◽  
Jos W.R. Twisk ◽  
Willem van Mechelen ◽  
Han C.G. Kemper

2011 ◽  
Vol 24 (1) ◽  
pp. 5-13 ◽  
Author(s):  
Christopher W. Kuzawa ◽  
Pedro C. Hallal ◽  
Linda Adair ◽  
Santosh K. Bhargava ◽  
Caroline H.D. Fall ◽  
...  

2012 ◽  
Vol 26 (4) ◽  
Author(s):  
Milan Čabrić ◽  
Helena Krakowiak ◽  
Ewa Sokołowska ◽  
Aleksandra Krakowiak

2020 ◽  
pp. 1-13
Author(s):  
Mariane da Silva Dias ◽  
Alicia Matijasevich ◽  
Aluísio JD Barros ◽  
Ana Maria B. Menezes ◽  
Bruna Celestino Schneider ◽  
...  

Abstract Objective: We aimed at evaluating the association of maternal pre-pregnancy nutritional status with offspring anthropometry and body composition. We also evaluated whether these associations were modified by gender, diet and physical activity and mediated by birth weight. Design: Birth cohort study. Setting: Waist circumference was measured with an inextensible tape, and fat and lean mass were measured using dual-energy X-ray absorptiometry. Multiple linear regression was used to adjust for possible confounders and allele score of BMI. We carried out mediation analysis using G-formula. Participants: In 1982, 1993 and 2004, all maternity hospitals in Pelotas (South Brazil) were visited daily and all live births whose families lived in the urban area of the city were evaluated. These subjects have been followed up at different ages. Results: Offspring of obese mothers had on average higher BMI, waist circumference and fat mass index than those of normal weight mothers, and these differences were higher among daughters. The magnitudes of the association were similar in the cohorts, except for height, where the association pattern was not clear. In the 1982 cohort, further adjustment for a BMI allele score had no material influence on the magnitude of the associations. Mediation analyses showed that birth weight captured part of this association. Conclusions: Our findings suggest that maternal pre-pregnancy nutritional status is positively associated with offspring BMI and adiposity in offspring. And this association is higher among daughters whose mother was overweight or obese and, birth weight explains part of this association.


2012 ◽  
Vol 303 (1) ◽  
pp. E111-E121 ◽  
Author(s):  
Biguang Tuo ◽  
Guorong Wen ◽  
Xue Wang ◽  
Jingyu Xu ◽  
Rui Xie ◽  
...  

The cause of lower prevalence of duodenal ulcer in young women compared with men is largely unknown. We recently found that sex difference in duodenal mucosal HCO3− secretion existed in humans and mice, but the mechanisms are not clear. Prostaglandin E2 (PGE2) is an important endogenous mediator that plays an important role in the regulation of duodenal HCO3− secretion. Therefore, in the present study, we investigated the effect of estrogen on PGE2-stimulated duodenal HCO3− secretion and the underlying mechanisms. The results showed that 17β-estradiol at the physiological concentration (1 nM) had no significant effects on duodenal mucosal HCO3− secretion or short-circuit current ( Isc) in mice. However, the pretreatment of 17β-estradiol (1 nM) markedly potentiated PGE2-stimulated duodenal HCO3− secretion and Isc ( P < 0.01 and P < 0.05). Global estrogen receptor (ER) antagonist ICI-182,780 and ERα-specific antagonist MPP, but not the ERβ-specific antagonist PHTPP, abolished estrogen-potentiated PGE2-stimulated duodenal HCO3− secretion and Isc. 17β-Estradiol and PGE2 additively increased phosphatidylinositol 3-kinase (PI3K) activity and Akt phosphorylation. Wortmannin, a specific PI3K inhibitor, inhibited estrogen-potentiated PGE2-stimulated duodenal HCO3− secretion and Isc. In conclusion, estrogen at the physiological concentration potentiates PGE2-stimulated duodenal mucosal HCO3− secretion through the activation of ERα and the PI3K-dependent mechanism, which may contribute to the sex difference in duodenal mucosal HCO3− secretion and the lower prevalence of duodenal ulcer in young women.


1981 ◽  
Vol 44 (1) ◽  
pp. 37-43 ◽  
Author(s):  
James E. Woods ◽  
Dianne M. Brazzill

PEDIATRICS ◽  
1987 ◽  
Vol 80 (5) ◽  
pp. 779-783
Author(s):  
David W. Harsha ◽  
Carey G. Smoak ◽  
Theresa A. Nicklas ◽  
Larry S. Webber ◽  
Gerald S. Berenson

Height, weight, and skinfold measurements were obtained on a cohort of 447 children from birth (weight) or 6 months of age (height and skinfold) and monitored yearly thereafter until 7 years of age. At age 7 years, 250 remained for follow-up screening. A significant degree of tracking was found for all variables from age 1 to age 7 years. Height and weight tracked most strongly (age 1- to 7-year correlations = .42 and .44, respectively), whereas skinfold tracked somewhat lower (.28). Earlier levels of each anthropometric variable were the best predictor of later levels of that parameter. Implications for early detection and treatment of growth abnormalities are discussed.


Pain ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Sarah D. Linnstaedt ◽  
Matthew C. Mauck ◽  
Esther YeEun Son ◽  
Andrew S. Tungate ◽  
Yue Pan ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document