Impact of cardiovascular risk factors on vessel wall inflammation and calcified plaque burden differs across vascular beds: a PET-CT study

2013 ◽  
Vol 29 (8) ◽  
pp. 1899-1908 ◽  
Author(s):  
Frederik F. Strobl ◽  
Axel Rominger ◽  
Sarah Wolpers ◽  
Carsten Rist ◽  
Fabian Bamberg ◽  
...  
SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A274-A274
Author(s):  
M Lu ◽  
Y Wei ◽  
Z Wang ◽  
F Fang ◽  
S E John ◽  
...  

Abstract Introduction OSA is closely associated with increased risk of coronary artery disease. Although previous small studies have investigated coronary plaque in OSA patients, limited data are available regarding the association of OSA with plaque morphology and composition. Therefore, we aimed to quantitatively characterize and compare coronary plaque burden and composition between patients with no or mild obstructive sleep apnea (OSA) and moderate-severe OSA using coronary computed tomography angiography (CTA) in a large-scale study. Methods We retrospectively analyzed consecutive patients who underwent sleep monitoring and coronary CTA. Metrics reflecting coronary plaque characteristics were compared between patients with no or mild OSA with apnea hypoxic index (AHI) ≤15 and moderate-severe OSA (AHI>15). The associations of OSA with coronary plaque components were determined by logistic and linear regression analysis. Results A total of 854 patients were enrolled in the study. Of these, 162 did not meet the inclusion criteria and of the remaining 692 patients 400 (57.8%) had moderate-severe OSA and 292 had no or mild OSA. Patients with moderate-severe OSA had a significantly higher total plaque volume, total non-calcified plaque (NCP) volume and total low density non-calcified plaque (LD-NCP) volume, and corresponding burden than those with no or mild OSA (all with p<0.05). Multivariate logistic regression analysis revealed that moderate-severe OSA patients are more likely to have any plaque, NCP and LD-NCP than those without no or mild OSA (p<0.05). In addition, stepwise multivariate linear regression analysis further revealed an independent relationship between moderate OSA (15<AHI≤30) and more so between severe OSA (AHI>30) and, NCP volume, LD-NCP volume, NCP composition, and LD-NCP composition, following adjustment for traditional cardiovascular risk factors, compared to no or mild OSA (AHI<15) (all with a p<0.05). Moderate-severe OSA conferred a similar odds ratio for LD-NCPs (a high-risk plaque) as the usual cardiovascular risk factors. Conclusion In this large cross-sectional study, OSA severity was associated with high-risk plaque features independent of traditional cardiovascular risk factors, suggesting an increased risk for cardiovascular events. Support This study was supported by NSFC (Project 81870335), International Science & Technology Cooperation Program of China (No.2015DFA30160), Beijing Municipal Science & Technology Commission (No. Z141100006014057)


2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Joshua P Rivers ◽  
Amit K Dey ◽  
Jonathan H Chung ◽  
Anshuma Rana ◽  
Abhishek Chaturvedi ◽  
...  

Background: Psoriasis (PSO), a chronic inflammatory disease associated with increased cardiovascular (CV) risk, provides a reliable human model to study inflammatory atherogenesis. PSO has been known to be associated with cardiometabolic dysfunction including adipose tissue dysfunction. Recently, visceral adiposity (VAT) was shown to be associated with increased CV events, but whether VAT is associated with subclinical atherosclerosis as assessed by coronary plaque burden has not been characterized. Hypothesis: We hypothesized that VAT volume by CT is associated with total burden (TB) and more specifically with non-calcified burden (NCB) by CCTA. Methods: Consecutive PSO patients (N=68) underwent CT scans to measure abdominal adiposity. VAT volume was quantified from the level of the diaphragm to the pubic symphysis and reported in volume. Coronary plaque characterization was performed by CCTA (Toshiba 30 slice) via QAngio CT software (Medis, The Netherlands). The relationship of VAT with TB and NCB was analyzed using unadjusted and adjusted multivariable regression models (STATA 12). Results: The cohort was middle-aged, predominantly male, at low CV risk by FRS with mild to moderate PSO by skin disease severity (Table 1). VAT volume associated with both TB (beta coefficient= 0.49, p-value <0.001) and NCB (beta coefficient= 0.51, p-value <0.001). This relationship remained significant after adjustment for cardiovascular risk factors for TB (beta coefficient= 0.28, p-value = 0.004) and NCB (beta coefficient = 0.34, p-value <0.001). Conclusions: Directly quantified VAT directly associated with TB and NCB independent of cardiovascular risk factors. These findings suggest that adipose tissue dysfunction may in part contribute to the high CV events observed in psoriasis and support efforts to provide weight control as a strategy to reduce CV disease in psoriasis.


2005 ◽  
Vol 6 (1) ◽  
pp. 125-126
Author(s):  
J. Pitha ◽  
M. Lejskova ◽  
S. Zecova ◽  
J. Kovar ◽  
P. Stavek ◽  
...  

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Tobias Saam ◽  
Axel Rominger ◽  
Sarah Wolpers ◽  
Clemens C Cyran ◽  
Peter Bartenstein ◽  
...  

Background Atherosclerosis is a systemic disease which is associated with increased vascular inflammation. The purpose of this study was to correlate glucose-uptake of arterial walls as measured by 18F-FDG PET-CT with the occurrence of cardio- and cerebrovascular events. Methods: 1000 tumor patients were examined by whole-body 18F-FDG PET-CT between 2004 to 2007. Patients’ clinical follow-up information could be obtained in 650 patients by telephone interviews (mean follow-up time 3,1y). In 22/650 patients (3.3%), cardio- or cerebrovascular events were registered, defined as cardiac death, myocardial infarction or revascularization and stroke. 6 out of 22 patients were not evaluable because of ongoing or prior steroid medication. In total, 16 PET-CT’s of patients with cardiovascular events could be evaluated and compared to PET-CT’s of 300 consecutive patients with known cardiovascular risk factors. Maximum standardized uptake values were measured from arterial walls of the ascending, thoracic and abdominal aorta, iliac and carotid arteries and corrected by dividing with the blood pool uptake in the vena cava (target-to-background ratio, TBR). Occurrence of events was correlated with TBR, age, cardiovascular risk factors and presence of calcified plaques using the Spearman’s correlation coefficient R. Multiple linear regression analysis was used to accommodate for differences in risk factors. Statistical significance was considered to be present when p<0.01. Results: Occurrence of events was significantly correlated with coronary heart disease (R=0.33; p<.001), arterial hypertension (R=0.22; p<.001), presence of hard plaques (R=0.15; p=.007) and TBR values (R=0.28; p<.001). No other significant correlations were found. When performing multiple regression analysis the association between the occurrence of events and TBR values/presence of coronary heart disease remained significant (p<.001). Conclusion: The findings of this study suggest that a higher arterial wall glucose uptake in tumor patients is associated with the occurrence of future cardio- and cerebrovascular events. TBR values as measured by 18F-FDG PET-CT could be useful for identifying high-risk patients in need of intensified medical or interventional therapy.


2018 ◽  
Vol 35 (5) ◽  
pp. 907-915
Author(s):  
Gaston A. Rodriguez-Granillo ◽  
Roxana Campisi ◽  
Exequiel Reynoso ◽  
Carlos Capunay ◽  
Patricia Carrascosa

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