scholarly journals Therapeutic targets during mitochondrial lipid metabolism

2020 ◽  
Vol 36 (3) ◽  
pp. 205-208 ◽  
Author(s):  
William Wang ◽  
Liyang Li ◽  
Xiangdong Wang
Keyword(s):  
Lipid Metabolism ◽  
Therapeutic Targets ◽  
Mitochondrial Lipid

scholarly journals Shengmai San Alleviates Diabetic Cardiomyopathy Through Improvement of Mitochondrial Lipid Metabolic Disorder

2018 ◽  
Vol 50 (5) ◽  
pp. 1726-1739 ◽  
Author(s):  
Jing Tian ◽  
Wenzhu Tang ◽  
Ming Xu ◽  
Chen Zhang ◽  
Pei Zhao ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Diastolic Dysfunction ◽  
Diabetic Cardiomyopathy ◽  
Leptin Receptor ◽  
Myocardial Hypertrophy ◽  
Oxphos Complex ◽  
H9c2 Cardiomyocytes ◽  
Mitochondrial Lipid ◽  
And Function ◽  
Shengmai San

Background/Aims: Shengmai San (SMS), prepared from Panax ginseng, Ophiopogon japonicus, and Schisandra chinensisin, has been widely used to treat ischemic disease. In this study, we investigated whether SMS may exert a beneficial effect in diabetic cardiomyopathy through improvement of mitochondrial lipid metabolism. Methods: A leptin receptor-deficient db/db mouse model was utilized, and lean age-matched C57BLKS mice served as non-diabetic controls. Glucose and lipid profiles, myocardial structure, dimension, and function, and heart weight to tibial length ratio were determined. Myocardial ultrastructural morphology was observed with transmission electron microscopy. Protein expression and activity of oxidative phosphorylation (OXPHOS) complex were assessed using western blotting and microplate assay kits. We also observed cellular viability, mitochondrial membrane potential, OXPHOS complex activity, and cellular ATP level in palmitic acid-stimulated H9C2 cardiomyocytes. Changes in the sirtuin (SIRT1)/AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) pathway and mitochondrial uncoupling signaling were assessed using western blotting and quantitative real-time PCR. Results: Leptin receptor-deficient db/db mice exhibit obesity, hyperglycemia, and hyperlipidemia, accompanied by distinct myocardial hypertrophy and diastolic dysfunction. SMS at a dose of 3 g/kg body weight contributed to a recovery of diabetes-induced myocardial hypertrophy and diastolic dysfunction. SMS administration led to an effective restoration of mitochondrial structure and function both in vivo and in vitro. Furthermore, SMS markedly enhanced SIRT1 and p-AMPKα protein levels and decreased the expression of acetylated-PGC-1α and uncoupling protein 2 protein. SMS also restored the depletion of NRF1 and TFAM levels in diabetic hearts and H9C2 cardiomyocytes. Conclusion: The results indicate that SMS may alleviate diabetes-induced myocardial hypertrophy and diastolic dysfunction by improving mitochondrial lipid metabolism.

scholarly journals MICRORNA ANALYSIS OF THE INVASIVE MARGIN OF GLIOBLASTOMA REVEALS DRUGGABLE THERAPEUTIC TARGETS IN LIPID METABOLISM PATHWAYS

2018 ◽  
Vol 20 (suppl_5) ◽  
pp. v348-v348
Author(s):  
Huda Alfardus ◽  
Maria de los Angeles Estevez Cebrero ◽  
Jonathan Rowlinson ◽  
Anbarasu Lourdusamy ◽  
Richard Grundy ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Therapeutic Targets ◽  
Invasive Margin

scholarly journals CBMT-35. MicroRNA ANALYSIS OF THE INVASIVE MARGIN OF GLIOBLASTOMA REVEALS DRUGGABLE THERAPEUTIC TARGETS IN LIPID METABOLISM PATHWAYS

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi40-vi40
Author(s):  
Huda Alfardus ◽  
Maria de los Angeles Estevez Cebrero ◽  
Jonathan Rawlinson ◽  
Anbarasu Lourdusamy ◽  
Richard Grundy ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Therapeutic Targets ◽  
Invasive Margin

Lipid metabolism in mammary neoplasia and potential therapeutic targets

2013 ◽  
Vol 1 (2) ◽  
pp. 16
Author(s):  
Ashlyn Williams ◽  
Lindsey Crawford ◽  
Amit K Tiwari ◽  
Temesgen Samuel ◽  
Gemechu Wirtu DVM, PhD
Keyword(s):  
Lipid Metabolism ◽  
Therapeutic Targets ◽  
Mammary Neoplasia

scholarly journals Disturbed bovine mitochondrial lipid metabolism: a review

2017 ◽  
Vol 37 (1) ◽  
pp. 262-273 ◽  
Author(s):  
J. H. (Han) van der Kolk ◽  
J. J. Gross ◽  
V. Gerber ◽  
R. M. Bruckmaier
Keyword(s):  
Lipid Metabolism ◽  
Mitochondrial Lipid

scholarly journals Differential and Synergistic Effects of Low Birth Weight and Western Diet on Skeletal Muscle Vasculature, Mitochondrial Lipid Metabolism and Insulin Signaling in Male Guinea Pigs

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4315
Author(s):  
Kristyn Dunlop ◽  
Ousseynou Sarr ◽  
Nicole Stachura ◽  
Lin Zhao ◽  
Karen Nygard ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Lipid Metabolism ◽  
Birth Weight ◽  
Amino Acid ◽  
Low Birth Weight ◽  
Insulin Signaling ◽  
Western Diet ◽  
High Fat ◽  
High Sugar ◽  
Mitochondrial Lipid

Low birth weight (LBW) offspring are at increased risk for developing insulin resistance, a key precursor in metabolic syndrome and type 2 diabetes mellitus. Altered skeletal muscle vasculature, extracellular matrix, amino acid and mitochondrial lipid metabolism, and insulin signaling are implicated in this pathogenesis. Using uteroplacental insufficiency (UPI) to induce intrauterine growth restriction (IUGR) and LBW in the guinea pig, we investigated the relationship between UPI-induced IUGR/LBW and later life skeletal muscle arteriole density, fibrosis, amino acid and mitochondrial lipid metabolism, markers of insulin signaling and glucose uptake, and how a postnatal high-fat, high-sugar “Western” diet (WD) modulates these changes. Muscle of 145-day-old male LBW glucose-tolerant offspring displayed diminished vessel density and altered acylcarnitine levels. Disrupted muscle insulin signaling despite maintained whole-body glucose homeostasis also occurred in both LBW and WD-fed male “lean” offspring. Additionally, postnatal WD unmasked LBW-induced impairment of mitochondrial lipid metabolism, as reflected by increased acylcarnitine accumulation. This study provides evidence that early markers of skeletal muscle metabolic dysfunction appear to be influenced by the in utero environment and interact with a high-fat/high-sugar postnatal environment to exacerbate altered mitochondrial lipid metabolism, promoting mitochondrial overload.

Molecular regulators of lipid metabolism in the intestine – Underestimated therapeutic targets for obesity?

2020 ◽  
Vol 178 ◽  
pp. 114091 ◽  
Author(s):  
Mercedes Dávalos-Salas ◽  
John M. Mariadason ◽  
Matthew J. Watt ◽  
Magdalene K. Montgomery
Keyword(s):  
Lipid Metabolism ◽  
Therapeutic Targets

scholarly journals P04.09 MicroRNA analysis of the invasive margin of Glioblastoma reveals druggable therapeutic targets in lipid metabolism pathways

2018 ◽  
Vol 20 (suppl_3) ◽  
pp. iii280-iii280
Author(s):  
H Alfardus ◽  
M de los Angeles Estevez Cebrero ◽  
J Rawlinson ◽  
A Lourdusamy ◽  
R Grundy ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Therapeutic Targets ◽  
Invasive Margin

scholarly journals LncRNAs as Therapeutic Targets and Potential Biomarkers for Lipid-Related Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Shi-Feng Huang ◽  
Xiao-Fei Peng ◽  
Lianggui Jiang ◽  
Ching Yuan Hu ◽  
Wen-Chu Ye
Keyword(s):  
Lipid Metabolism ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Therapeutic Targets ◽  
Lipid Homeostasis ◽  
Hormone Regulation ◽  
Future Studies ◽  
Underlying Mechanisms ◽  
Potential Biomarkers

Lipid metabolism is an essential biological process involved in nutrient adjustment, hormone regulation, and lipid homeostasis. An irregular lifestyle and long-term nutrient overload can cause lipid-related diseases, including atherosclerosis, myocardial infarction (MI), obesity, and fatty liver diseases. Thus, novel tools for efficient diagnosis and treatment of dysfunctional lipid metabolism are urgently required. Furthermore, it is known that lncRNAs based regulation like sponging microRNAs (miRNAs) or serving as a reservoir for microRNAs play an essential role in the progression of lipid-related diseases. Accordingly, a better understanding of the regulatory roles of lncRNAs in lipid-related diseases would provide the basis for identifying potential biomarkers and therapeutic targets for lipid-related diseases. This review highlighted the latest advances on the potential biomarkers of lncRNAs in lipid-related diseases and summarised current knowledge on dysregulated lncRNAs and their potential molecular mechanisms. We have also provided novel insights into the underlying mechanisms of lncRNAs which might serve as potential biomarkers and therapeutic targets for lipid-related diseases. The information presented here may be useful for designing future studies and advancing investigations of lncRNAs as biomarkers for diagnosis, prognosis, and therapy of lipid-related diseases.

Sign in / Sign up

Export Citation Format

Share Document