Lipid metabolism in mammary neoplasia and potential therapeutic targets

2013 ◽  
Vol 1 (2) ◽  
pp. 16
Author(s):  
Ashlyn Williams ◽  
Lindsey Crawford ◽  
Amit K Tiwari ◽  
Temesgen Samuel ◽  
Gemechu Wirtu DVM, PhD
Keyword(s):  
Lipid Metabolism ◽  
Therapeutic Targets ◽  
Mammary Neoplasia

scholarly journals MICRORNA ANALYSIS OF THE INVASIVE MARGIN OF GLIOBLASTOMA REVEALS DRUGGABLE THERAPEUTIC TARGETS IN LIPID METABOLISM PATHWAYS

2018 ◽  
Vol 20 (suppl_5) ◽  
pp. v348-v348
Author(s):  
Huda Alfardus ◽  
Maria de los Angeles Estevez Cebrero ◽  
Jonathan Rowlinson ◽  
Anbarasu Lourdusamy ◽  
Richard Grundy ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Therapeutic Targets ◽  
Invasive Margin

scholarly journals CBMT-35. MicroRNA ANALYSIS OF THE INVASIVE MARGIN OF GLIOBLASTOMA REVEALS DRUGGABLE THERAPEUTIC TARGETS IN LIPID METABOLISM PATHWAYS

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi40-vi40
Author(s):  
Huda Alfardus ◽  
Maria de los Angeles Estevez Cebrero ◽  
Jonathan Rawlinson ◽  
Anbarasu Lourdusamy ◽  
Richard Grundy ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Therapeutic Targets ◽  
Invasive Margin

Molecular regulators of lipid metabolism in the intestine – Underestimated therapeutic targets for obesity?

2020 ◽  
Vol 178 ◽  
pp. 114091 ◽  
Author(s):  
Mercedes Dávalos-Salas ◽  
John M. Mariadason ◽  
Matthew J. Watt ◽  
Magdalene K. Montgomery
Keyword(s):  
Lipid Metabolism ◽  
Therapeutic Targets

scholarly journals P04.09 MicroRNA analysis of the invasive margin of Glioblastoma reveals druggable therapeutic targets in lipid metabolism pathways

2018 ◽  
Vol 20 (suppl_3) ◽  
pp. iii280-iii280
Author(s):  
H Alfardus ◽  
M de los Angeles Estevez Cebrero ◽  
J Rawlinson ◽  
A Lourdusamy ◽  
R Grundy ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Therapeutic Targets ◽  
Invasive Margin

scholarly journals LncRNAs as Therapeutic Targets and Potential Biomarkers for Lipid-Related Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Shi-Feng Huang ◽  
Xiao-Fei Peng ◽  
Lianggui Jiang ◽  
Ching Yuan Hu ◽  
Wen-Chu Ye
Keyword(s):  
Lipid Metabolism ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Therapeutic Targets ◽  
Lipid Homeostasis ◽  
Hormone Regulation ◽  
Future Studies ◽  
Underlying Mechanisms ◽  
Potential Biomarkers

Lipid metabolism is an essential biological process involved in nutrient adjustment, hormone regulation, and lipid homeostasis. An irregular lifestyle and long-term nutrient overload can cause lipid-related diseases, including atherosclerosis, myocardial infarction (MI), obesity, and fatty liver diseases. Thus, novel tools for efficient diagnosis and treatment of dysfunctional lipid metabolism are urgently required. Furthermore, it is known that lncRNAs based regulation like sponging microRNAs (miRNAs) or serving as a reservoir for microRNAs play an essential role in the progression of lipid-related diseases. Accordingly, a better understanding of the regulatory roles of lncRNAs in lipid-related diseases would provide the basis for identifying potential biomarkers and therapeutic targets for lipid-related diseases. This review highlighted the latest advances on the potential biomarkers of lncRNAs in lipid-related diseases and summarised current knowledge on dysregulated lncRNAs and their potential molecular mechanisms. We have also provided novel insights into the underlying mechanisms of lncRNAs which might serve as potential biomarkers and therapeutic targets for lipid-related diseases. The information presented here may be useful for designing future studies and advancing investigations of lncRNAs as biomarkers for diagnosis, prognosis, and therapy of lipid-related diseases.

Nuclear Receptors in Acute and Chronic Cholestasis

2015 ◽  
Vol 33 (3) ◽  
pp. 357-366 ◽  
Author(s):  
Ester Gonzalez-Sanchez ◽  
Delphine Firrincieli ◽  
Chantal Housset ◽  
Nicolas Chignard
Keyword(s):  
Lipid Metabolism ◽  
Nuclear Receptors ◽  
Energy Homeostasis ◽  
Therapeutic Targets ◽  
Pregnane X Receptor ◽  
Estrogen Receptor Α ◽  
Farnesoid X Receptor ◽  
Peroxisome Proliferator ◽  
Hepatic Expression ◽  
The Impact

Background: Nuclear receptors (NRs) form a family of 48 members. NRs control hepatic processes such as bile acid homeostasis, lipid metabolism and mechanisms involved in fibrosis and inflammation. Due to their central role in the regulation of hepatoprotective mechanisms, NRs are promising therapeutic targets in cholestatic disorders. Key Messages: NRs can be classified into five different physiological clusters. NRs from the ‘bile acids and xenobiotic metabolism' and from the ‘lipid metabolism and energy homeostasis' clusters are strongly expressed in the liver. Furthermore, NRs from these clusters, such as farnesoid X receptor α (FXRα), pregnane X receptor (PXR) and peroxisome proliferator-activated receptors (PPARs), have been associated with the pathogenesis and the progression of cholestasis. The latter observation is also true for vitamin D receptor (VDR), which is barely detectable in the whole liver, but has been linked to cholestatic diseases. Involvement of VDR in cholestasis is ascribed to a strong expression in nonparenchymal liver cells, such as biliary epithelial cells, Kupffer cells and hepatic stellate cells. Likewise, NRs from other physiological clusters with low hepatic expression, such as estrogen receptor α (ERα) or reverse-Erb α/β (REV-ERB α/β), may also control pathophysiological processes in cholestasis. Conclusions: In this review, we will describe the impact of individual NRs on cholestasis. We will then discuss the potential role of these transcription factors as therapeutic targets.

scholarly journals Therapeutic targets during mitochondrial lipid metabolism

2020 ◽  
Vol 36 (3) ◽  
pp. 205-208 ◽  
Author(s):  
William Wang ◽  
Liyang Li ◽  
Xiangdong Wang
Keyword(s):  
Lipid Metabolism ◽  
Therapeutic Targets ◽  
Mitochondrial Lipid

scholarly journals Regulatory and therapeutic potential for obesity

2019 ◽  
Vol 15 (4) ◽  
pp. 483-492
Author(s):  
O. E. Poluliakh ◽  
E. I. Kalinovskaya ◽  
A. A. Basalai
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Literature Review ◽  
Therapeutic Potential ◽  
Therapeutic Targets ◽  
Biological Processes ◽  
Glucose And Lipid Metabolism ◽  
New Biomarkers ◽  
Obesity Drugs

A literature review about the role of microrna in biological processes associated with .obesity was completed. Modern ideas about micrornas, their biogenesis and their role in the formation of adipose tissue, glucose and lipid metabolism were described. The possibilities of using microRNA as new biomarkers and therapeutic targets for development of anti-obesity drugs were considered.

Sign in / Sign up

Export Citation Format

Share Document