Host matrix metalloproteinase-9 contributes to tumor vascularization without affecting tumor growth in a model of prostate cancer bone metastasis

2006 ◽  
Vol 23 (7-8) ◽  
pp. 335-344 ◽  
Author(s):  
Sanaa M. Nabha ◽  
R. Daniel Bonfil ◽  
Hamilto A. Yamamoto ◽  
Abdelfettah Belizi ◽  
Christoph Wiesner ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Matrix Metalloproteinase ◽  
Tumor Growth ◽  
Matrix Metalloproteinase 9 ◽  
Tumor Vascularization ◽  
Host Matrix ◽  
Metalloproteinase 9

Systemic administration of a soluble betaglycan suppresses tumor growth, angiogenesis, and matrix metalloproteinase-9 expression in a human xenograft model of prostate cancer

The Prostate ◽  
2004 ◽  
Vol 63 (1) ◽  
pp. 81-90 ◽  
Author(s):  
Abhik Bandyopadhyay ◽  
Long Wang ◽  
Fernando López-Casillas ◽  
Valentín Mendoza ◽  
I-Tien Yeh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Tumor Growth ◽  
Xenograft Model ◽  
Matrix Metalloproteinase 9 ◽  
Systemic Administration ◽  
Metalloproteinase 9

Plasma matrix metalloproteinase 9 as biomarker of prostate cancer progression in Dunning (Copenhagen) rats

The Prostate ◽  
2002 ◽  
Vol 54 (3) ◽  
pp. 206-211 ◽  
Author(s):  
Klaus Jung ◽  
Hans-Willi Krell ◽  
Bernhard Ortel ◽  
Tayyaba Hasan ◽  
Andreas Römer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Matrix Metalloproteinase 9 ◽  
Prostate Cancer Progression ◽  
Metalloproteinase 9

Use of nanocurcumin to inhibit proliferation and metastases of hepatocellular carcinoma via NF-κB mediated matrix metalloproteinase-9 downregulation.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e22103-e22103
Author(s):  
Yang Xu ◽  
Bo Hu ◽  
Robert Anders ◽  
Anirban Maitra ◽  
Jia Fan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Matrix Metalloproteinase ◽  
Tumor Growth ◽  
Cell Lines ◽  
Primary Tumor ◽  
Matrix Metalloproteinase 9 ◽  
Primary Tumor Growth ◽  
Metalloproteinase 9

e22103 Background: Curcumin regulates the expression and secretion of MMPs, and has potent anti-cancer properties in several human cancer cell lines and animal carcinogenesis models. In this study we try to investigate the effects of polymeric nanoparticle encapsulated formulation of curcumin– nanocurcumin (NC) on Hepatocellular carcinoma (HCC) in vitro and in vivo. Methods: The effects of NC alone and in combination with sorafenib (SO) were investigated on HCC cell lines, Huh7 and MHCCLM3 in vitro by using proliferation and invasion assay, western blot, qRT-PCR, enzyme-linked immunosorbent assay and immunohistochemistry staining, and the subcutaneous and orthotopic HCC xenograft nude mice models (MHCCLM3) were used to evaluate primary tumor growth and metastasis after treatments. Results: NC alone (or combined with SO)inhibited HCC cell proliferation (p<0.05) and invasion in vitro (p<0.01), and remarkably decreased both the subcutaneous and orthotopic primary tumor growth and lung metastases in vivo. NC and/or SO could down-regulating the expressions of Matrix Metalloproteinase-9 (MMP9), p-ERK1 and NF-kB/p65 (p<0.05). Conclusions: NC showed potent anti-invasion and metastasis properties in HCC via NF-κB mediated MMP9 down-regulation, which may provide a new strategy to the treatment of HCC patients and prevention of tumor recurrence after operation.

Abstract 5007: WT1 promotes tumor growth and vascularization by regulating matrix metalloproteinase 9 in Ewing's sarcoma xenografts

2011 ◽  
Author(s):  
Varalakshmi Katuri ◽  
Hans- Joerg Hammers ◽  
Stephanie Gerber ◽  
Xiaofei Qiu ◽  
Elizabeth Montgomery ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Tumor Growth ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9
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