Plasma matrix metalloproteinase 9 as biomarker of prostate cancer progression in Dunning (Copenhagen) rats

The Prostate ◽  
2002 ◽  
Vol 54 (3) ◽  
pp. 206-211 ◽  
Author(s):  
Klaus Jung ◽  
Hans-Willi Krell ◽  
Bernhard Ortel ◽  
Tayyaba Hasan ◽  
Andreas Römer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Matrix Metalloproteinase 9 ◽  
Prostate Cancer Progression ◽  
Metalloproteinase 9

scholarly journals Activation of the Osteopontin/Matrix Metalloproteinase-9 Pathway Correlates with Prostate Cancer Progression

2008 ◽  
Vol 14 (22) ◽  
pp. 7470-7480 ◽  
Author(s):  
Giancarlo Castellano ◽  
Grazia Malaponte ◽  
Maria C. Mazzarino ◽  
Mariangela Figini ◽  
Francesco Marchese ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Matrix Metalloproteinase 9 ◽  
Prostate Cancer Progression ◽  
Metalloproteinase 9

scholarly journals Oxidative Stress and Prostate Cancer Progression Are Elicited by Membrane-Type 1 Matrix Metalloproteinase

2011 ◽  
Vol 9 (10) ◽  
pp. 1305-1318 ◽  
Author(s):  
Hoang-Lan Nguyen ◽  
Stanley Zucker ◽  
Kevin Zarrabi ◽  
Pournima Kadam ◽  
Cathleen Schmidt ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Membrane Type

Host matrix metalloproteinase-9 contributes to tumor vascularization without affecting tumor growth in a model of prostate cancer bone metastasis

2006 ◽  
Vol 23 (7-8) ◽  
pp. 335-344 ◽  
Author(s):  
Sanaa M. Nabha ◽  
R. Daniel Bonfil ◽  
Hamilto A. Yamamoto ◽  
Abdelfettah Belizi ◽  
Christoph Wiesner ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Matrix Metalloproteinase ◽  
Tumor Growth ◽  
Matrix Metalloproteinase 9 ◽  
Tumor Vascularization ◽  
Host Matrix ◽  
Metalloproteinase 9

scholarly journals The Role of the Metzincin Superfamily in Prostate Cancer Progression: A Systematic-Like Review

2021 ◽  
Vol 22 (7) ◽  
pp. 3608
Author(s):  
Marley J. Binder ◽  
Alister C. Ward
Keyword(s):  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Prognostic Indicators ◽  
Prostate Cancer Progression ◽  
The Matrix ◽  
A Disintegrin And Metalloproteinase ◽  
Narrative Forms ◽  
Timp Family

Prostate cancer remains a leading cause of cancer-related morbidity in men. Potentially important regulators of prostate cancer progression are members of the metzincin superfamily of proteases, principally through their regulation of the extracellular matrix. It is therefore timely to review the role of the metzincin superfamily in prostate cancer and its progression to better understand their involvement in this disease. A systematic-like search strategy was conducted. Articles that investigated the roles of members of the metzincin superfamily and their key regulators in prostate cancer were included. The extracted articles were synthesized and data presented in tabular and narrative forms. Two hundred and five studies met the inclusion criteria. Of these, 138 investigated the role of the Matrix Metalloproteinase (MMP) subgroup, 34 the Membrane-Tethered Matrix Metalloproteinase (MT-MMP) subgroup, 22 the A Disintegrin and Metalloproteinase (ADAM) subgroup, 8 the A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) subgroup and 53 the Tissue Inhibitor of Metalloproteinases (TIMP) family of regulators, noting that several studies investigated multiple family members. There was clear evidence that specific members of the metzincin superfamily are involved in prostate cancer progression, which can be either in a positive or negative manner. However, further understanding of their mechanisms of action and how they may be used as prognostic indicators or molecular targets is required.

scholarly journals Immunoexpression of Matrix Metalloproteinase-9 in Histopathological tissue samples of oral Squamous Cell Carcinoma

2021 ◽  
Vol 15 (10) ◽  
pp. 2666-2669
Author(s):  
Fiza Shafiq ◽  
Abbas Saleem Khan ◽  
Sajjad Ahmad ◽  
Malik Arshman Khan ◽  
Sikandar Javed , Bajwa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Matrix Metalloproteinase ◽  
Cell Carcinoma ◽  
Cancer Progression ◽  
Squamous Cell ◽  
Matrix Metalloproteinase 9 ◽  
Healthy Individuals ◽  
Metalloproteinase 9

Background: Oral cancer represents a significant component of the global cancer burden. It develops as a result of multiple risk factors. The main histological form of oral cancer is oral squamous cell carcinoma (OSCC). The disintegration of the extracellular matrix (ECM) is one of the key hallmarks of cancer progression, which stimulates the invasion of tumoral cells into the neighbouring tissue. Matrix metalloproteinases-9 (MMP-9) can degrade different elements of the ECM and basement membrane. Methods: A total of 35 histologically diagnosed cases of OSCC (n=25) and healthy individuals (n=10) as control were included. Immunohistochemical staining was performed on all cases. The results were analysed using SPSS version 20. Results: Increased expression of MMP-9 was observed in OSCC cases (n=23/25; 92%) as compared to healthy individuals. Statistically, a significant relation was observed while comparing the grade of staining intensity and MMP-9 expression among OSCC cases (p=0.001). Conclusion: The present study is planned to assess the immunohistochemical expression of MMP-9 in diagnosed cases of OSCC and healthy individuals. Increased expression of MMP-9 was observed in OSCC as compared to healthy individuals. Evaluation of MMP-9 could be of clinical importance in OSCC and can be used as a diagnostic predictive marker of OSCC. Keywords: Oral squamous cell carcinoma; Matrix Metalloproteinase -9; Immunohistochemistry

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